145835

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 420399..420927 Replicon chromosome
Accession NZ_CP047298
Organism Vibrio cholerae O1 biovar El Tor strain C6709

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag GTF73_RS16070 Protein ID WP_000221354.1
Coordinates 420640..420927 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag GTF73_RS16065 Protein ID WP_001250179.1
Coordinates 420399..420650 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF73_RS16020 415667..415981 + 315 WP_000071008.1 DNA-binding transcriptional regulator -
GTF73_RS16025 416118..416552 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
GTF73_RS16030 416720..416875 + 156 WP_000751734.1 hypothetical protein -
GTF73_RS16035 417000..417980 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
GTF73_RS16040 418048..418320 + 273 Protein_451 CatB-related O-acetyltransferase -
GTF73_RS16045 418491..419183 + 693 WP_001047169.1 GNAT family N-acetyltransferase -
GTF73_RS16050 419183..419584 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
GTF73_RS16055 419554..419697 + 144 WP_071908341.1 DUF3265 domain-containing protein -
GTF73_RS16060 419772..420185 + 414 WP_000049417.1 VOC family protein -
GTF73_RS16065 420399..420650 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GTF73_RS16070 420640..420927 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTF73_RS16075 421055..421510 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
GTF73_RS16080 421832..421984 + 153 WP_001884520.1 DUF645 family protein -
GTF73_RS16085 422186..422683 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
GTF73_RS16090 422680..422952 - 273 WP_000246253.1 DUF1778 domain-containing protein -
GTF73_RS16095 423183..423851 + 669 WP_000043871.1 hypothetical protein -
GTF73_RS16100 424003..424290 + 288 WP_000426470.1 hypothetical protein -
GTF73_RS16105 424431..424802 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
GTF73_RS16110 424869..425294 + 426 WP_001882332.1 DUF1778 domain-containing protein -
GTF73_RS16115 425291..425824 + 534 WP_000118351.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306901..436162 129261
inside Integron - - 311981..435786 123805
flank IS/Tn - - 417000..417980 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T145835 WP_000221354.1 NZ_CP047298:420640-420927 [Vibrio cholerae O1 biovar El Tor]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T145835 NZ_CP062702:c452549-452064 [Escherichia coli O157:H7]
ATGGGAATAACGGCTCCTACTCCCCTAACGTCTGAACATAATCTGGCTGACTTTTGCTGTTCCGATCACGGGATGAATGA
ATGGCTAAAAAAGAAAGCGTTAAAAAATCACAGCTCCGGTCTGTCTCGTGTTTACGTTATCTGTATTGCCAATACCCGCC
AGGTAATCGGCTATTACTGCCTTTCTACAGGCAGTATTCAACGTAATTTGGCCCCTGGAGCCATGCGACGTAATGCTCCC
GAATCGTTGCCTGTTGTCGTATTAGGCAGACTGGCAATTGATCAAGCCTGGGCAGGTAAAGGGTTGGGCGTCGCATTGTT
GAAAGATGCAGTCTATCGCACAATGTCCATAGCTCAACAGGTAGGGGTTCGTGCGCTCATTGTTCATGCCTTAGACGATT
CAGTACGCAATTTCTATCTGAAGTATGCCTTTGTACCTTCACCATTCCAGTCACTTACCTTACTGTATCCCATTACTCTG
GAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT145835 WP_001250179.1 NZ_CP047298:420399-420650 [Vibrio cholerae O1 biovar El Tor]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT145835 NZ_CP062702:c452818-452540 [Escherichia coli O157:H7]
ATGAAACCGGAAAGCAAAGAAGCGCCAATCAATATCAGAGCGAAAGCCTCACAGCGTGACCTGATTGATATGGCAGCGAA
TCTGGTCGCAAAATCGCGCACTGATTTTATGCTGGATGCCGCATGCCGTGAAGCGCAAGACATCTTATTAGATCAACGAC
TATTCATCCTTGATGACGAGCAATACGATGCGTTTCTCGCTGCCCTGGACGCCCCCATCACTGCTGAGCGTCAGGCCAAA
ATTAACGCGTTGATGAATCGTAAATCGCCATGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X1KZS6

Antitoxin

Source ID Structure
AlphaFold DB A0A0X1KZS8

References