Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-GNAT
Location 578988..580081 Replicon chromosome
Accession NZ_CP013310
Organism Vibrio cholerae strain E1162

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag ASZ87_RS17660 Protein ID WP_000351248.1
Coordinates 579680..580081 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag ASZ87_RS17655 Protein ID WP_001047169.1
Coordinates 578988..579680 (+) Length 231 a.a.

Genomic Context

ASZ87_RS17585ASZ87_RS21130ASZ87_RS17590ASZ87_RS17605ASZ87_RS17610ASZ87_RS17620ASZ87_RS17625ASZ87_RS17630ASZ87_RS20915ASZ87_RS17650ASZ87_RS17655ASZ87_RS17660ASZ87_RS20820ASZ87_RS17670ASZ87_RS17675ASZ87_RS17680ASZ87_RS17685ASZ87_RS17695ASZ87_RS17710ASZ87_RS17715ASZ87_RS17645ASZ87_RS17700ASZ87_RS17705
Location: 574271..574648 (378 bp)
Type: Others
Protein ID: WP_000411109.1
Location: 574705..574819 (115 bp)
Type: Others
Protein ID: Protein_601
Location: 574768..575049 (282 bp)
Type: Others
Protein ID: WP_001894453.1
Location: 575215..575328 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 575277..575504 (228 bp)
Type: Others
Protein ID: WP_001894457.1
Location: 575845..576177 (333 bp)
Type: Others
Protein ID: WP_000843587.1
Location: 576164..576478 (315 bp)
Type: Others
Protein ID: WP_000071008.1
Location: 576615..577049 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 577217..577372 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 578545..578851 (307 bp)
Type: Others
Protein ID: Protein_610
Location: 578988..579680 (693 bp)
Type: Antitoxin
Protein ID: WP_001047169.1
Location: 579680..580081 (402 bp)
Type: Toxin
Protein ID: WP_000351248.1
Location: 580051..580194 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 580269..580682 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 580896..581147 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 581137..581424 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 581552..582007 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 582329..582481 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 583680..584348 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 584500..584787 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 577497..578477 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 582683..583180 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 583177..583449 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ87_RS17585574271..574648+378WP_000411109.1hypothetical protein-
ASZ87_RS21130574705..574819+115Protein_601acetyltransferase-
ASZ87_RS17590574768..575049+282WP_001894453.1DUF1289 domain-containing protein-
ASZ87_RS17605575215..575328+114WP_001889158.1hypothetical protein-
ASZ87_RS17610575277..575504+228WP_001894457.1DUF1289 domain-containing protein-
ASZ87_RS17620575845..576177+333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ87_RS17625576164..576478+315WP_000071008.1DNA-binding transcriptional regulator-
ASZ87_RS17630576615..577049+435WP_000256036.1GNAT family N-acetyltransferase-
ASZ87_RS20915577217..577372+156WP_000751734.1hypothetical protein-
ASZ87_RS17645577497..578477-981WP_000019370.1IS5-like element ISVch5 family transposase-
ASZ87_RS17650578545..578851+307Protein_610CatB-related O-acetyltransferase-
ASZ87_RS17655578988..579680+693WP_001047169.1GNAT family N-acetyltransferaseAntitoxin
ASZ87_RS17660579680..580081+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxinToxin
ASZ87_RS20820580051..580194+144WP_071908341.1DUF3265 domain-containing protein-
ASZ87_RS17670580269..580682+414WP_000049417.1VOC family protein-
ASZ87_RS17675580896..581147+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ87_RS17680581137..581424+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ87_RS17685581552..582007+456WP_001245327.1GNAT family N-acetyltransferase-
ASZ87_RS17695582329..582481+153WP_001884520.1DUF645 family protein-
ASZ87_RS17700582683..583180-498WP_000982260.1GNAT family N-acetyltransferase-
ASZ87_RS17705583177..583449-273WP_000246253.1DUF1778 domain-containing protein-
ASZ87_RS17710583680..584348+669WP_000043871.1hypothetical protein-
ASZ87_RS17715584500..584787+288WP_000426470.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-435534..596659161125
insideIntegron--440614..596283155669
flankIS/Tn--577497..578477980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin

GNAT domain

(36-153)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T58316 WP_000351248.1 NZ_CP013310:579680-580081 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T58316 NZ_CP013310:579680-580081 [Vibrio cholerae]
ATGGATATCATCTGTTTTCCTTTTGAACGAGTGATCGAGATTAATGCTTTCATCCTAAAAACAGAACCAGGAATGAAAGG
AGCCGTTGATATTCCCAAGCTTCAGGGGGCATTAGGTCGAATCGATAATGCCATCGTTTATGAAGGACTGGATGATGTTT
TTGAAATCGCTGCTAAATACACTGCTTGTATAGCGGTTTCACATGCGCTACCTGATGCGAACAAACGCACAGGTTTGGCT
GTGGCACTTGAATATTTATCACTTAACGATTTTGAGCTTACGCAGGAAAACGATTTACTTGCGGATGCAGTTCGAGATCT
TGTTATCGGCATTATCAACGAAACAGATTTTGCCGACATTCTCTACGCACAATACGCAAAAGAACAAAATTCAGCTCTCT
AA

Antitoxin


Download         Length: 231 a.a.        Molecular weight: 26352.73 Da        Isoelectric Point: 8.5633

>AT58316 WP_001047169.1 NZ_CP013310:578988-579680 [Vibrio cholerae]
MNLEEFQESDFDLLIKWIDSDELNYLWGCPAYVFPLTYEQIHSHCSKAEVFPYLLKVKGRHAGFVELYKVTDEQYRICRV
FISNAYRGQGLSKSMLMLLIDKARLDFSATKLSLGVFEQNTVARKCYESLGFEVVMVVVIEFGGMRCQPLRRALCFLSRF
GAIIGLTFIDSRCDMNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 693 bp

>AT58316 NZ_CP013310:578988-579680 [Vibrio cholerae]
ATGAACTTAGAAGAGTTTCAAGAATCGGATTTTGACCTGCTTATAAAATGGATTGACTCAGATGAGTTGAACTATTTATG
GGGTTGCCCTGCGTATGTTTTCCCGCTGACTTATGAACAGATCCATTCCCACTGTAGCAAAGCGGAAGTATTTCCCTATC
TGCTAAAAGTGAAAGGTAGACATGCCGGGTTTGTTGAGTTGTACAAAGTCACCGATGAGCAATATCGGATTTGCCGTGTC
TTTATTTCAAATGCTTATCGTGGGCAAGGGCTATCAAAATCGATGTTGATGTTATTAATCGATAAAGCCCGATTAGATTT
TTCTGCAACCAAGCTTAGCTTAGGCGTTTTTGAACAGAACACAGTTGCTAGAAAATGCTATGAGTCATTAGGTTTTGAAG
TGGTTATGGTTGTTGTGATTGAGTTTGGCGGTATGCGTTGTCAGCCCCTTAGGCGGGCGTTATGTTTTTTATCACGTTTT
GGGGCTATAATCGGCCTAACCTTTATTGATAGTAGGTGTGATATGAATCGAAAAGTTGAAGCTTACGGCGTTGATGCTGT
TGAAAGACCGAAAATTAAGGCTAGTAAAAAGCTTGATTTGACTGGTGATGCTGGTCGTCAAATTGTGAAGTCTGAAACTA
AACTTGCTTTGCGTACTCATCAGAAGACATTCACTAAATTGGCTGATATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0PN34

Antitoxin

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Source
ID
Structure
No matching records found

References