Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 76935..77463 Replicon chromosome
Accession NZ_AP024548
Organism Vibrio cholerae strain BCH-01536

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag K6J77_RS14470 Protein ID WP_000221352.1
Coordinates 76935..77225 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag K6J77_RS14475 Protein ID WP_000213183.1
Coordinates 77215..77463 (-) Length 83 a.a.

Genomic Context

K6J77_RS19055K6J77_RS19060K6J77_RS14435K6J77_RS19065K6J77_RS14445K6J77_RS14450K6J77_RS14455K6J77_RS19070K6J77_RS14460K6J77_RS14465K6J77_RS14480K6J77_RS14485K6J77_RS14490K6J77_RS14495K6J77_RS14500K6J77_RS14505K6J77_RS14470K6J77_RS14475K6J77_RS14510
Location: 72205..72315 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 72354..72464 (111 bp)
Type: Others
Protein ID: Protein_137
Location: 72492..72617 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 72580..72696 (117 bp)
Type: Others
Protein ID: WP_001889170.1
Location: 72884..73888 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 74041..74487 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 74607..75536 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 75533..75643 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 75671..76147 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 76338..76799 (462 bp)
Type: Others
Protein ID: WP_001911752.1
Location: 78034..78687 (654 bp)
Type: Others
Protein ID: WP_000036957.1
Location: 78959..79384 (426 bp)
Type: Others
Protein ID: WP_000415748.1
Location: 79592..79987 (396 bp)
Type: Others
Protein ID: WP_000649527.1
Location: 80138..80668 (531 bp)
Type: Others
Protein ID: WP_000415563.1
Location: 80806..81306 (501 bp)
Type: Others
Protein ID: WP_000789723.1
Location: 81462..81860 (399 bp)
Type: Others
Protein ID: WP_001882293.1
Location: 76935..77225 (291 bp)
Type: Toxin
Protein ID: WP_000221352.1
Location: 77215..77463 (249 bp)
Type: Antitoxin
Protein ID: WP_000213183.1
Location: 81960..82424 (465 bp)
Type: Others
Protein ID: WP_000140244.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K6J77_RS1905572205..72315+111WP_134814058.1DUF3265 domain-containing protein-
K6J77_RS1906072354..72464+111Protein_137acetyltransferase-
K6J77_RS1443572492..72617+126WP_001944767.1DUF645 family protein-
K6J77_RS1906572580..72696+117WP_001889170.1hypothetical protein-
K6J77_RS1444572884..73888+1005WP_000964925.1LD-carboxypeptidase-
K6J77_RS1445074041..74487+447WP_000128977.1hypothetical protein-
K6J77_RS1445574607..75536+930WP_000335802.1hypothetical protein-
K6J77_RS1907075533..75643+111WP_071917832.1DUF3265 domain-containing protein-
K6J77_RS1446075671..76147+477WP_001047180.1GNAT family N-acetyltransferase-
K6J77_RS1446576338..76799+462WP_001911752.1lipocalin family protein-
K6J77_RS1447076935..77225-291WP_000221352.1type II toxin-antitoxin system RelE/ParE family toxinToxin
K6J77_RS1447577215..77463-249WP_000213183.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
K6J77_RS1448078034..78687+654WP_000036957.1site-specific DNA-methyltransferase-
K6J77_RS1448578959..79384+426WP_000415748.1hypothetical protein-
K6J77_RS1449079592..79987+396WP_000649527.1DUF3465 domain-containing protein-
K6J77_RS1449580138..80668+531WP_000415563.1hypothetical protein-
K6J77_RS1450080806..81306+501WP_000789723.1hypothetical protein-
K6J77_RS1450581462..81860+399WP_001882293.1hypothetical protein-
K6J77_RS1451081960..82424-465WP_000140244.1hypothetical protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideIntegron--11978..113648101670


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T38624 WP_000221352.1 NZ_AP024548:c77225-76935 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T38624 NZ_AP024548:c77225-76935 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT38624 WP_000213183.1 NZ_AP024548:c77463-77215 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT38624 NZ_AP024548:c77463-77215 [Vibrio cholerae]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBH9L4R3

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A366A3W8

References