38624

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 76935..77463 Replicon chromosome
Accession NZ_AP024548
Organism Vibrio cholerae strain BCH-01536

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag K6J77_RS14470 Protein ID WP_000221352.1
Coordinates 76935..77225 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag K6J77_RS14475 Protein ID WP_000213183.1
Coordinates 77215..77463 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J77_RS19055 72205..72315 + 111 WP_134814058.1 DUF3265 domain-containing protein -
K6J77_RS19060 72354..72464 + 111 Protein_137 acetyltransferase -
K6J77_RS14435 72492..72617 + 126 WP_001944767.1 DUF645 family protein -
K6J77_RS19065 72580..72696 + 117 WP_001889170.1 hypothetical protein -
K6J77_RS14445 72884..73888 + 1005 WP_000964925.1 LD-carboxypeptidase -
K6J77_RS14450 74041..74487 + 447 WP_000128977.1 hypothetical protein -
K6J77_RS14455 74607..75536 + 930 WP_000335802.1 hypothetical protein -
K6J77_RS19070 75533..75643 + 111 WP_071917832.1 DUF3265 domain-containing protein -
K6J77_RS14460 75671..76147 + 477 WP_001047180.1 GNAT family N-acetyltransferase -
K6J77_RS14465 76338..76799 + 462 WP_001911752.1 lipocalin family protein -
K6J77_RS14470 76935..77225 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6J77_RS14475 77215..77463 - 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K6J77_RS14480 78034..78687 + 654 WP_000036957.1 site-specific DNA-methyltransferase -
K6J77_RS14485 78959..79384 + 426 WP_000415748.1 hypothetical protein -
K6J77_RS14490 79592..79987 + 396 WP_000649527.1 DUF3465 domain-containing protein -
K6J77_RS14495 80138..80668 + 531 WP_000415563.1 hypothetical protein -
K6J77_RS14500 80806..81306 + 501 WP_000789723.1 hypothetical protein -
K6J77_RS14505 81462..81860 + 399 WP_001882293.1 hypothetical protein -
K6J77_RS14510 81960..82424 - 465 WP_000140244.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integron - - 11978..113648 101670


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T38624 WP_000221352.1 NZ_AP024548:c77225-76935 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T38624 NZ_AP024548:c77225-76935 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT38624 WP_000213183.1 NZ_AP024548:c77463-77215 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT38624 NZ_AP024548:c77463-77215 [Vibrio cholerae]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References