Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 258050..258628 Replicon chromosome
Accession NZ_AP024554
Organism Vibrio cholerae strain IDH-03329

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag K6J80_RS15180 Protein ID WP_001180243.1
Coordinates 258311..258628 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag K6J80_RS15175 Protein ID WP_000557292.1
Coordinates 258050..258292 (+) Length 81 a.a.

Genomic Context

K6J80_RS15175K6J80_RS15180K6J80_RS18990K6J80_RS15135K6J80_RS18995K6J80_RS19000K6J80_RS15140K6J80_RS15145K6J80_RS19005K6J80_RS15150K6J80_RS15155K6J80_RS19010K6J80_RS15160K6J80_RS19015K6J80_RS15165K6J80_RS15170K6J80_RS19020K6J80_RS19025K6J80_RS15190K6J80_RS15195K6J80_RS15200K6J80_RS19030K6J80_RS19035K6J80_RS15210K6J80_RS15215K6J80_RS15220K6J80_RS19040K6J80_RS15225
Location: 258050..258292 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
Location: 258311..258628 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 253450..253566 (117 bp)
Type: Others
Protein ID: WP_001889170.1
Location: 253529..253654 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 253682..253792 (111 bp)
Type: Others
Protein ID: Protein_262
Location: 253831..253941 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 253938..254255 (318 bp)
Type: Others
Protein ID: WP_001232701.1
Location: 254266..254553 (288 bp)
Type: Others
Protein ID: WP_001162670.1
Location: 254594..254707 (114 bp)
Type: Others
Protein ID: WP_001894955.1
Location: 254820..255000 (181 bp)
Type: Others
Protein ID: Protein_267
Location: 255425..255658 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 255679..255872 (194 bp)
Type: Others
Protein ID: Protein_269
Location: 256061..256279 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 256291..256500 (210 bp)
Type: Others
Protein ID: WP_001900246.1
Location: 256589..257242 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 257299..257808 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 258822..258974 (153 bp)
Type: Others
Protein ID: Protein_276
Location: 259035..259210 (176 bp)
Type: Others
Protein ID: Protein_277
Location: 259273..259566 (294 bp)
Type: Others
Protein ID: WP_125460920.1
Location: 259713..260060 (348 bp)
Type: Others
Protein ID: WP_000933409.1
Location: 260209..260634 (426 bp)
Type: Others
Protein ID: WP_000403014.1
Location: 260793..260903 (111 bp)
Type: Others
Protein ID: WP_223804330.1
Location: 260893..260955 (63 bp)
Type: Others
Protein ID: Protein_282
Location: 261306..261842 (537 bp)
Type: Others
Protein ID: WP_000644491.1
Location: 261986..262381 (396 bp)
Type: Others
Protein ID: WP_000046953.1
Location: 262558..262677 (120 bp)
Type: Others
Protein ID: WP_001900954.1
Location: 262800..262943 (144 bp)
Type: Others
Protein ID: Protein_286
Location: 263042..263437 (396 bp)
Type: Others
Protein ID: WP_000046952.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K6J80_RS18990253450..253566-117WP_001889170.1hypothetical protein-
K6J80_RS15135253529..253654-126WP_001944767.1DUF645 family protein-
K6J80_RS18995253682..253792-111Protein_262acetyltransferase-
K6J80_RS19000253831..253941-111WP_134814058.1DUF3265 domain-containing protein-
K6J80_RS15140253938..254255-318WP_001232701.1HigA family addiction module antitoxin-
K6J80_RS15145254266..254553-288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxin-
K6J80_RS19005254594..254707-114WP_001894955.1hypothetical protein-
K6J80_RS15150254820..255000-181Protein_267DUF645 family protein-
K6J80_RS15155255425..255658-234WP_032482776.1DUF3709 domain-containing protein-
K6J80_RS19010255679..255872-194Protein_269hypothetical protein-
K6J80_RS15160256061..256279-219WP_001917086.1DUF3709 domain-containing protein-
K6J80_RS19015256291..256500-210WP_001900246.1DUF3709 domain-containing protein-
K6J80_RS15165256589..257242-654WP_000226874.1hypothetical protein-
K6J80_RS15170257299..257808-510WP_000405987.1GNAT family N-acetyltransferase-
K6J80_RS15175258050..258292+243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
K6J80_RS15180258311..258628+318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
K6J80_RS19020258822..258974-153Protein_276DUF645 family protein-
K6J80_RS19025259035..259210-176Protein_277acetyltransferase-
K6J80_RS15190259273..259566-294WP_125460920.1hypothetical protein-
K6J80_RS15195259713..260060-348WP_000933409.1hypothetical protein-
K6J80_RS15200260209..260634-426WP_000403014.1GNAT family N-acetyltransferase-
K6J80_RS19030260793..260903-111WP_223804330.1Tfp pilus assembly protein-
K6J80_RS19035260893..260955-63Protein_282DUF645 family protein-
K6J80_RS15210261306..261842-537WP_000644491.1nucleotidyltransferase family protein-
K6J80_RS15215261986..262381-396WP_000046953.1DUF6404 family protein-
K6J80_RS15220262558..262677-120WP_001900954.1DUF645 family protein-
K6J80_RS19040262800..262943-144Protein_286acetyltransferase-
K6J80_RS15225263042..263437-396WP_000046952.1DUF6404 family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-213119..319686106567
insideIntegron--213119..31285699737


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T38678 WP_001180243.1 NZ_AP024554:258311-258628 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T38678 NZ_AP024554:258311-258628 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT38678 WP_000557292.1 NZ_AP024554:258050-258292 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT38678 NZ_AP024554:258050-258292 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References