38678

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 258050..258628 Replicon chromosome
Accession NZ_AP024554
Organism Vibrio cholerae strain IDH-03329

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag K6J80_RS15180 Protein ID WP_001180243.1
Coordinates 258311..258628 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag K6J80_RS15175 Protein ID WP_000557292.1
Coordinates 258050..258292 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J80_RS18990 253450..253566 - 117 WP_001889170.1 hypothetical protein -
K6J80_RS15135 253529..253654 - 126 WP_001944767.1 DUF645 family protein -
K6J80_RS18995 253682..253792 - 111 Protein_262 acetyltransferase -
K6J80_RS19000 253831..253941 - 111 WP_134814058.1 DUF3265 domain-containing protein -
K6J80_RS15140 253938..254255 - 318 WP_001232701.1 HigA family addiction module antitoxin -
K6J80_RS15145 254266..254553 - 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
K6J80_RS19005 254594..254707 - 114 WP_001894955.1 hypothetical protein -
K6J80_RS15150 254820..255000 - 181 Protein_267 DUF645 family protein -
K6J80_RS15155 255425..255658 - 234 WP_032482776.1 DUF3709 domain-containing protein -
K6J80_RS19010 255679..255872 - 194 Protein_269 hypothetical protein -
K6J80_RS15160 256061..256279 - 219 WP_001917086.1 DUF3709 domain-containing protein -
K6J80_RS19015 256291..256500 - 210 WP_001900246.1 DUF3709 domain-containing protein -
K6J80_RS15165 256589..257242 - 654 WP_000226874.1 hypothetical protein -
K6J80_RS15170 257299..257808 - 510 WP_000405987.1 GNAT family N-acetyltransferase -
K6J80_RS15175 258050..258292 + 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K6J80_RS15180 258311..258628 + 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6J80_RS19020 258822..258974 - 153 Protein_276 DUF645 family protein -
K6J80_RS19025 259035..259210 - 176 Protein_277 acetyltransferase -
K6J80_RS15190 259273..259566 - 294 WP_125460920.1 hypothetical protein -
K6J80_RS15195 259713..260060 - 348 WP_000933409.1 hypothetical protein -
K6J80_RS15200 260209..260634 - 426 WP_000403014.1 GNAT family N-acetyltransferase -
K6J80_RS19030 260793..260903 - 111 WP_223804330.1 Tfp pilus assembly protein -
K6J80_RS19035 260893..260955 - 63 Protein_282 DUF645 family protein -
K6J80_RS15210 261306..261842 - 537 WP_000644491.1 nucleotidyltransferase family protein -
K6J80_RS15215 261986..262381 - 396 WP_000046953.1 DUF6404 family protein -
K6J80_RS15220 262558..262677 - 120 WP_001900954.1 DUF645 family protein -
K6J80_RS19040 262800..262943 - 144 Protein_286 acetyltransferase -
K6J80_RS15225 263042..263437 - 396 WP_000046952.1 DUF6404 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 213119..319686 106567
inside Integron - - 213119..312856 99737


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T38678 WP_001180243.1 NZ_AP024554:258311-258628 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T38678 NZ_AP024554:258311-258628 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT38678 WP_000557292.1 NZ_AP024554:258050-258292 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT38678 NZ_AP024554:258050-258292 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References