Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 459150..459697 Replicon chromosome
Accession NZ_CP013302
Organism Vibrio cholerae strain C5

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag ASZ80_RS17055 Protein ID WP_000229317.1
Coordinates 459395..459697 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag ASZ80_RS17050 Protein ID WP_000861987.1
Coordinates 459150..459407 (+) Length 86 a.a.

Genomic Context

ASZ80_RS17000ASZ80_RS17010ASZ80_RS17025ASZ80_RS17030ASZ80_RS17035ASZ80_RS17040ASZ80_RS17045ASZ80_RS17050ASZ80_RS17055ASZ80_RS17060ASZ80_RS17070ASZ80_RS17075ASZ80_RS17080ASZ80_RS17085ASZ80_RS17095ASZ80_RS17100ASZ80_RS20705ASZ80_RS17015ASZ80_RS17020
Location: 454179..454634 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 454956..455108 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 456307..456975 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 457127..457414 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 457555..457926 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 457993..458418 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 458415..458948 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 459150..459407 (258 bp)
Type: Antitoxin
Protein ID: WP_000861987.1
Location: 459395..459697 (303 bp)
Type: Toxin
Protein ID: WP_000229317.1
Location: 459931..460848 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 461005..461394 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 461530..461739 (210 bp)
Type: Others
Protein ID: Protein_522
Location: 461858..462295 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 462359..462577 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 462752..463624 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 463774..464373 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 464430..464534 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 455310..455807 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 455804..456076 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ80_RS17000454179..454634+456WP_001245327.1GNAT family N-acetyltransferase-
ASZ80_RS17010454956..455108+153WP_001884520.1DUF645 family protein-
ASZ80_RS17015455310..455807-498WP_000982260.1GNAT family N-acetyltransferase-
ASZ80_RS17020455804..456076-273WP_000246253.1DUF1778 domain-containing protein-
ASZ80_RS17025456307..456975+669WP_000043871.1hypothetical protein-
ASZ80_RS17030457127..457414+288WP_000426470.1hypothetical protein-
ASZ80_RS17035457555..457926+372WP_001164080.1nucleotide pyrophosphohydrolase-
ASZ80_RS17040457993..458418+426WP_001882332.1DUF1778 domain-containing protein-
ASZ80_RS17045458415..458948+534WP_000118351.1GNAT family N-acetyltransferase-
ASZ80_RS17050459150..459407+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
ASZ80_RS17055459395..459697+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ASZ80_RS17060459931..460848+918WP_000186333.1alpha/beta hydrolase-
ASZ80_RS17070461005..461394+390WP_001081302.1hypothetical protein-
ASZ80_RS17075461530..461739+210Protein_522GNAT family N-acetyltransferase-
ASZ80_RS17080461858..462295+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
ASZ80_RS17085462359..462577+219WP_071908318.1GNAT family N-acetyltransferase-
ASZ80_RS17095462752..463624+873WP_000254716.1DUF3800 domain-containing protein-
ASZ80_RS17100463774..464373+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
ASZ80_RS20705464430..464534+105WP_099607150.1acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304694..469286164592
insideIntegron--309774..468910159136
flankIS/Tn--461858..462295437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T58232 WP_000229317.1 NZ_CP013302:459395-459697 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T58232 NZ_CP013302:459395-459697 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT58232 WP_000861987.1 NZ_CP013302:459150-459407 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT58232 NZ_CP013302:459150-459407 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM92

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1T4SLM9

References