58232

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 459150..459697 Replicon chromosome
Accession NZ_CP013302
Organism Vibrio cholerae strain C5

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag ASZ80_RS17055 Protein ID WP_000229317.1
Coordinates 459395..459697 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag ASZ80_RS17050 Protein ID WP_000861987.1
Coordinates 459150..459407 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ80_RS17000 454179..454634 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
ASZ80_RS17010 454956..455108 + 153 WP_001884520.1 DUF645 family protein -
ASZ80_RS17015 455310..455807 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
ASZ80_RS17020 455804..456076 - 273 WP_000246253.1 DUF1778 domain-containing protein -
ASZ80_RS17025 456307..456975 + 669 WP_000043871.1 hypothetical protein -
ASZ80_RS17030 457127..457414 + 288 WP_000426470.1 hypothetical protein -
ASZ80_RS17035 457555..457926 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
ASZ80_RS17040 457993..458418 + 426 WP_001882332.1 DUF1778 domain-containing protein -
ASZ80_RS17045 458415..458948 + 534 WP_000118351.1 GNAT family N-acetyltransferase -
ASZ80_RS17050 459150..459407 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ASZ80_RS17055 459395..459697 + 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ASZ80_RS17060 459931..460848 + 918 WP_000186333.1 alpha/beta hydrolase -
ASZ80_RS17070 461005..461394 + 390 WP_001081302.1 hypothetical protein -
ASZ80_RS17075 461530..461739 + 210 Protein_522 GNAT family N-acetyltransferase -
ASZ80_RS17080 461858..462295 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
ASZ80_RS17085 462359..462577 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
ASZ80_RS17095 462752..463624 + 873 WP_000254716.1 DUF3800 domain-containing protein -
ASZ80_RS17100 463774..464373 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
ASZ80_RS20705 464430..464534 + 105 WP_099607150.1 acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304694..469286 164592
inside Integron - - 309774..468910 159136
flank IS/Tn - - 461858..462295 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T58232 WP_000229317.1 NZ_CP013302:459395-459697 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T58232 NZ_CP013302:459395-459697 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT58232 WP_000861987.1 NZ_CP013302:459150-459407 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT58232 NZ_CP013302:459150-459407 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9KM92

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References