Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 253938..254553 Replicon chromosome
Accession NZ_AP024554
Organism Vibrio cholerae strain IDH-03329

Toxin (Protein)


Gene name higB Uniprot ID Q9KMG5
Locus tag K6J80_RS15145 Protein ID WP_001162670.1
Coordinates 254266..254553 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K6J80_RS15140 Protein ID WP_001232701.1
Coordinates 253938..254255 (-) Length 106 a.a.

Genomic Context

K6J80_RS15175K6J80_RS15180K6J80_RS15105K6J80_RS15110K6J80_RS18985K6J80_RS15115K6J80_RS15120K6J80_RS15125K6J80_RS18990K6J80_RS15135K6J80_RS18995K6J80_RS19000K6J80_RS15140K6J80_RS15145K6J80_RS19005K6J80_RS15150K6J80_RS15155K6J80_RS19010K6J80_RS15160K6J80_RS19015K6J80_RS15165K6J80_RS15170K6J80_RS19020K6J80_RS19025
Location: 258050..258292 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 258311..258628 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 249347..249808 (462 bp)
Type: Others
Protein ID: WP_001911752.1
Location: 249999..250475 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 250503..250613 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 250610..251539 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 251659..252105 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 252258..253262 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 253450..253566 (117 bp)
Type: Others
Protein ID: WP_001889170.1
Location: 253529..253654 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 253682..253792 (111 bp)
Type: Others
Protein ID: Protein_262
Location: 253831..253941 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 253938..254255 (318 bp)
Type: Antitoxin
Protein ID: WP_001232701.1
Location: 254266..254553 (288 bp)
Type: Toxin
Protein ID: WP_001162670.1
Location: 254594..254707 (114 bp)
Type: Others
Protein ID: WP_001894955.1
Location: 254820..255000 (181 bp)
Type: Others
Protein ID: Protein_267
Location: 255425..255658 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 255679..255872 (194 bp)
Type: Others
Protein ID: Protein_269
Location: 256061..256279 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 256291..256500 (210 bp)
Type: Others
Protein ID: WP_001900246.1
Location: 256589..257242 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 257299..257808 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 258822..258974 (153 bp)
Type: Others
Protein ID: Protein_276
Location: 259035..259210 (176 bp)
Type: Others
Protein ID: Protein_277
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K6J80_RS15105249347..249808-462WP_001911752.1lipocalin family protein-
K6J80_RS15110249999..250475-477WP_001047180.1GNAT family N-acetyltransferase-
K6J80_RS18985250503..250613-111WP_071917832.1DUF3265 domain-containing protein-
K6J80_RS15115250610..251539-930WP_000335802.1hypothetical protein-
K6J80_RS15120251659..252105-447WP_000128977.1hypothetical protein-
K6J80_RS15125252258..253262-1005WP_000964925.1LD-carboxypeptidase-
K6J80_RS18990253450..253566-117WP_001889170.1hypothetical protein-
K6J80_RS15135253529..253654-126WP_001944767.1DUF645 family protein-
K6J80_RS18995253682..253792-111Protein_262acetyltransferase-
K6J80_RS19000253831..253941-111WP_134814058.1DUF3265 domain-containing protein-
K6J80_RS15140253938..254255-318WP_001232701.1HigA family addiction module antitoxinAntitoxin
K6J80_RS15145254266..254553-288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxinToxin
K6J80_RS19005254594..254707-114WP_001894955.1hypothetical protein-
K6J80_RS15150254820..255000-181Protein_267DUF645 family protein-
K6J80_RS15155255425..255658-234WP_032482776.1DUF3709 domain-containing protein-
K6J80_RS19010255679..255872-194Protein_269hypothetical protein-
K6J80_RS15160256061..256279-219WP_001917086.1DUF3709 domain-containing protein-
K6J80_RS19015256291..256500-210WP_001900246.1DUF3709 domain-containing protein-
K6J80_RS15165256589..257242-654WP_000226874.1hypothetical protein-
K6J80_RS15170257299..257808-510WP_000405987.1GNAT family N-acetyltransferase-
K6J80_RS15175258050..258292+243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
K6J80_RS15180258311..258628+318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
K6J80_RS19020258822..258974-153Protein_276DUF645 family protein-
K6J80_RS19025259035..259210-176Protein_277acetyltransferase-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-213119..319686106567
insideIntegron--213119..31285699737


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11349.95 Da        Isoelectric Point: 6.7187

>T38677 WP_001162670.1 NZ_AP024554:c254553-254266 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Download         Length: 288 bp

>T38677 NZ_AP024554:c254553-254266 [Vibrio cholerae]
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11705.63 Da        Isoelectric Point: 10.4711

>AT38677 WP_001232701.1 NZ_AP024554:c254255-253938 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Download         Length: 318 bp

>AT38677 NZ_AP024554:c254255-253938 [Vibrio cholerae]
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTCAGTAATTTAATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCCGCGGCATTAGGTAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A0F2HI36

Antitoxin

Loading, please wait
Source
ID
Structure
No matching records found

References