Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 279056..279822 Replicon chromosome
Accession NZ_LT992493
Organism Vibrio cholerae strain 4295STDY6534248

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag DG169_RS16115 Protein ID WP_000982260.1
Coordinates 279056..279553 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag DG169_RS16120 Protein ID WP_000246253.1
Coordinates 279550..279822 (-) Length 91 a.a.

Genomic Context

DG169_RS16065DG169_RS16070DG169_RS16075DG169_RS16080DG169_RS16085DG169_RS16090DG169_RS16095DG169_RS16100DG169_RS16105DG169_RS16125DG169_RS16130DG169_RS16135DG169_RS16140DG169_RS16145DG169_RS16155DG169_RS16160DG169_RS16170DG169_RS16115DG169_RS16120
Location: 274918..275224 (307 bp)
Type: Others
Protein ID: Protein_305
Location: 275361..276053 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 276053..276454 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 276424..276567 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 276642..277055 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 277269..277520 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 277510..277797 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 277925..278380 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 278702..278854 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 280053..280721 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 280873..281160 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 281301..281672 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 281739..282164 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 282161..282694 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 282896..283153 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 283141..283443 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 283677..284594 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 279056..279553 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 279550..279822 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DG169_RS16065274918..275224+307Protein_305CatB-related O-acetyltransferase-
DG169_RS16070275361..276053+693WP_001047169.1GNAT family N-acetyltransferase-
DG169_RS16075276053..276454+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
DG169_RS16080276424..276567+144WP_071908341.1DUF3265 domain-containing protein-
DG169_RS16085276642..277055+414WP_000049417.1VOC family protein-
DG169_RS16090277269..277520+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
DG169_RS16095277510..277797+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
DG169_RS16100277925..278380+456WP_001245327.1GNAT family N-acetyltransferase-
DG169_RS16105278702..278854+153WP_001884520.1DUF645 family protein-
DG169_RS16115279056..279553-498WP_000982260.1GNAT family N-acetyltransferaseToxin
DG169_RS16120279550..279822-273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
DG169_RS16125280053..280721+669WP_000043871.1hypothetical protein-
DG169_RS16130280873..281160+288WP_000426470.1hypothetical protein-
DG169_RS16135281301..281672+372WP_001164080.1nucleotide pyrophosphohydrolase-
DG169_RS16140281739..282164+426WP_001882332.1DUF1778 domain-containing protein-
DG169_RS16145282161..282694+534WP_000118351.1GNAT family N-acetyltransferase-
DG169_RS16155282896..283153+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
DG169_RS16160283141..283443+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
DG169_RS16170283677..284594+918WP_000186333.1alpha/beta hydrolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-197768..29303295264
insideIntegroncatB9-202848..29265689808
flankIS/Tn--273870..274850980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T294417 WP_000982260.1 NZ_LT992493:c279553-279056 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT294417 WP_000246253.1 NZ_LT992493:c279822-279550 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References