Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 334809..335307 Replicon chromosome
Accession NZ_CP047298
Organism Vibrio cholerae O1 biovar El Tor strain C6709

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag GTF73_RS15310 Protein ID WP_000589156.1
Coordinates 334809..335075 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag GTF73_RS15315 Protein ID WP_000643598.1
Coordinates 335062..335307 (+) Length 82 a.a.

Genomic Context

GTF73_RS15255GTF73_RS15260GTF73_RS15265GTF73_RS15270GTF73_RS15275GTF73_RS15280GTF73_RS15285GTF73_RS15290GTF73_RS15295GTF73_RS15300GTF73_RS15305GTF73_RS15310GTF73_RS15315GTF73_RS15320GTF73_RS15325GTF73_RS15330GTF73_RS15335GTF73_RS15340GTF73_RS15345GTF73_RS15350GTF73_RS15355
Location: 330229..330435 (207 bp)
Type: Others
Protein ID: Protein_294
Location: 330635..330736 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 330726..331112 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 331307..331558 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 331531..331680 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 331772..332014 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 332266..332544 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 332919..333062 (144 bp)
Type: Others
Protein ID: Protein_301
Location: 333116..333154 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 333366..333833 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 333961..334624 (664 bp)
Type: Others
Protein ID: Protein_304
Location: 334809..335075 (267 bp)
Type: Toxin
Protein ID: WP_000589156.1
Location: 335062..335307 (246 bp)
Type: Antitoxin
Protein ID: WP_000643598.1
Location: 335403..336197 (795 bp)
Type: Others
Protein ID: WP_001911581.1
Location: 336300..336428 (129 bp)
Type: Others
Protein ID: WP_071908338.1
Location: 336489..336671 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 336887..337891 (1005 bp)
Type: Others
Protein ID: WP_000964920.1
Location: 338044..338403 (360 bp)
Type: Others
Protein ID: WP_001071541.1
Location: 338676..338909 (234 bp)
Type: Others
Protein ID: WP_001890112.1
Location: 339177..339683 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 339840..340226 (387 bp)
Type: Others
Protein ID: WP_000703163.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTF73_RS15255330229..330435+207Protein_294DUF3709 domain-containing protein-
GTF73_RS15260330635..330736+102WP_001921603.1hypothetical protein-
GTF73_RS15265330726..331112+387WP_000703163.1VOC family protein-
GTF73_RS15270331307..331558+252WP_001890111.1TIGR03643 family protein-
GTF73_RS15275331531..331680+150WP_071908333.1DUF3265 domain-containing protein-
GTF73_RS15280331772..332014+243WP_000107461.1hypothetical protein-
GTF73_RS15285332266..332544+279WP_000280324.1DUF3709 domain-containing protein-
GTF73_RS15290332919..333062+144Protein_301DUF645 family protein-
GTF73_RS15295333116..333154+39WP_082798268.1hypothetical protein-
GTF73_RS15300333366..333833+468WP_001289288.1OsmC family protein-
GTF73_RS15305333961..334624+664Protein_304hypothetical protein-
GTF73_RS15310334809..335075+267WP_000589156.1BrnT family toxinToxin
GTF73_RS15315335062..335307+246WP_000643598.1hypothetical proteinAntitoxin
GTF73_RS15320335403..336197+795WP_001911581.1hypothetical protein-
GTF73_RS15325336300..336428+129WP_071908338.1general secretion pathway protein GspI-
GTF73_RS15330336489..336671+183WP_000923182.1DUF645 family protein-
GTF73_RS15335336887..337891+1005WP_000964920.1LD-carboxypeptidase-
GTF73_RS15340338044..338403+360WP_001071541.1VOC family protein-
GTF73_RS15345338676..338909+234WP_001890112.1DUF3709 domain-containing protein-
GTF73_RS15350339177..339683+507WP_000393074.1hypothetical protein-
GTF73_RS15355339840..340226+387WP_000703163.1VOC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306901..436162129261
insideIntegron--311981..435786123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T145826 WP_000589156.1 NZ_CP047298:334809-335075 [Vibrio cholerae O1 biovar El Tor]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T145826 NZ_CP062700:c4936915-4936565 [Escherichia coli O157:H7]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT145826 WP_000643598.1 NZ_CP047298:335062-335307 [Vibrio cholerae O1 biovar El Tor]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT145826 NZ_CP062700:c4937160-4936909 [Escherichia coli O157:H7]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGTGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A271VMP7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A271VME2

References