Detailed information of TA system TA145820

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DhiAT/-
• Location: 431444..432228
• Replicon: chromosome
• Accession: NZ_CP047296
• Organism: Vibrio cholerae C6706

Toxin (Protein)

• Gene name: dhiT
• Uniprot ID: A0A086SLD6
• Locus tag: GTF72_RS16145
• Protein ID: WP_001114075.1
• Coordinates: 431444..431713 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: dhiA
• Uniprot ID: Q9KM84
• Locus tag: GTF72_RS16150
• Protein ID: WP_000921691.1
• Coordinates: 431707..432228 (+)
• Length: 174 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GTF72_RS16105	426810..427727	+	918	WP_000186333.1	alpha/beta hydrolase	-
GTF72_RS16110	427884..428273	+	390	WP_001081302.1	hypothetical protein	-
GTF72_RS16115	428409..428618	+	210	Protein_471	GNAT family N-acetyltransferase	-
GTF72_RS16120	428737..429174	+	438	WP_000503169.1	IS200/IS605-like element IS1004 family transposase	-
GTF72_RS16125	429238..429456	+	219	WP_071908318.1	GNAT family N-acetyltransferase	-
GTF72_RS16130	429631..430503	+	873	WP_000254716.1	DUF3800 domain-containing protein	-
GTF72_RS16135	430653..431252	+	600	WP_001891245.1	glutathione S-transferase N-terminal domain-containing protein	-
GTF72_RS16140	431309..431413	+	105	WP_099607150.1	acetyltransferase	-
GTF72_RS16145	431444..431713	+	270	WP_001114075.1	DUF4160 domain-containing protein	Toxin
GTF72_RS16150	431707..432228	+	522	WP_000921691.1	DUF2442 domain-containing protein	Antitoxin
GTF72_RS16155	432527..432652	+	126	WP_001905700.1	DUF645 family protein	-
GTF72_RS16160	432903..433298	+	396	WP_001000867.1	hypothetical protein	-
GTF72_RS16165	433437..433715	-	279	WP_000578476.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
GTF72_RS16170	433712..433996	-	285	WP_000381183.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
GTF72_RS16175	434190..434705	+	516	WP_000343779.1	GNAT family N-acetyltransferase	-
GTF72_RS16180	434762..434857	+	96	WP_099607151.1	acetyltransferase	-
GTF72_RS16185	434889..435302	+	414	WP_000049420.1	VOC family protein	-
GTF72_RS16190	435309..435441	-	133	Protein_486	hypothetical protein	-
GTF72_RS16195	435857..437034	+	1178	WP_086010879.1	IS3-like element ISVch4 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	306905..436165	129260
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 Integron TA000164, TA000169, TA000166, TA000167, TA000179, TA000170, TA000171, TA000172, TA000173, TA000174, TA000175, TA000176, TA000177, TA000178, TA000168, TA000165, TA010030, TA010035 309750..435387 0	inside	Integron	-	-	311985..435789	123804
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 IS/Tn TA000179, TA000177, TA000178, TA010035 428335..428772 0	flank	IS/Tn	-	-	428737..429174	437

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF4160 (9-74)

Antitoxin

• Protein of unknown function DUF2442 (4-59)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10310.94 Da
• Isoelectric Point: 6.6303

>T145820 WP_001114075.1 NZ_CP047296:431444-431713 [Vibrio cholerae C6706]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Nucleotide

• Length: 270 bp

>T145820 NZ_CP062700:3669976-3670362 [Escherichia coli O157:H7]
ATGGGTGTGTATAAGGCAAGGCGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAAGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGGTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAAGCAAAGAAATCGAAGATGATGAACTGGCAGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTCTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin

Protein

• Length: 174 a.a.
• Molecular weight: 19409.01 Da
• Isoelectric Point: 6.7342

>AT145820 WP_000921691.1 NZ_CP047296:431707-432228 [Vibrio cholerae C6706]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Nucleotide

• Length: 522 bp

>AT145820 NZ_CP062700:3670352-3670681 [Escherichia coli O157:H7]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAGGTTGA
TGCCATTGCCGTCATGGTCAAAGCCCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Structures

Toxin

• AlphaFold DB: A0A086SLD6

Antitoxin

• AlphaFold DB: Q9KM84