Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 431444..432228 Replicon chromosome
Accession NZ_CP047296
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag GTF72_RS16145 Protein ID WP_001114075.1
Coordinates 431444..431713 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag GTF72_RS16150 Protein ID WP_000921691.1
Coordinates 431707..432228 (+) Length 174 a.a.

Genomic Context

GTF72_RS16105GTF72_RS16110GTF72_RS16115GTF72_RS16120GTF72_RS16125GTF72_RS16130GTF72_RS16135GTF72_RS16140GTF72_RS16145GTF72_RS16150GTF72_RS16155GTF72_RS16160GTF72_RS16175GTF72_RS16180GTF72_RS16185GTF72_RS16195GTF72_RS16165GTF72_RS16170GTF72_RS16190
Location: 426810..427727 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 427884..428273 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 428409..428618 (210 bp)
Type: Others
Protein ID: Protein_471
Location: 428737..429174 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 429238..429456 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 429631..430503 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 430653..431252 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 431309..431413 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 431444..431713 (270 bp)
Type: Toxin
Protein ID: WP_001114075.1
Location: 431707..432228 (522 bp)
Type: Antitoxin
Protein ID: WP_000921691.1
Location: 432527..432652 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 432903..433298 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 434190..434705 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 434762..434857 (96 bp)
Type: Others
Protein ID: WP_099607151.1
Location: 434889..435302 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 435857..437034 (1178 bp)
Type: Others
Protein ID: WP_086010879.1
Location: 433437..433715 (279 bp)
Type: Others
Protein ID: WP_000578476.1
Location: 433712..433996 (285 bp)
Type: Others
Protein ID: WP_000381183.1
Location: 435309..435441 (133 bp)
Type: Others
Protein ID: Protein_486
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTF72_RS16105426810..427727+918WP_000186333.1alpha/beta hydrolase-
GTF72_RS16110427884..428273+390WP_001081302.1hypothetical protein-
GTF72_RS16115428409..428618+210Protein_471GNAT family N-acetyltransferase-
GTF72_RS16120428737..429174+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
GTF72_RS16125429238..429456+219WP_071908318.1GNAT family N-acetyltransferase-
GTF72_RS16130429631..430503+873WP_000254716.1DUF3800 domain-containing protein-
GTF72_RS16135430653..431252+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
GTF72_RS16140431309..431413+105WP_099607150.1acetyltransferase-
GTF72_RS16145431444..431713+270WP_001114075.1DUF4160 domain-containing proteinToxin
GTF72_RS16150431707..432228+522WP_000921691.1DUF2442 domain-containing proteinAntitoxin
GTF72_RS16155432527..432652+126WP_001905700.1DUF645 family protein-
GTF72_RS16160432903..433298+396WP_001000867.1hypothetical protein-
GTF72_RS16165433437..433715-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family-
GTF72_RS16170433712..433996-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
GTF72_RS16175434190..434705+516WP_000343779.1GNAT family N-acetyltransferase-
GTF72_RS16180434762..434857+96WP_099607151.1acetyltransferase-
GTF72_RS16185434889..435302+414WP_000049420.1VOC family protein-
GTF72_RS16190435309..435441-133Protein_486hypothetical protein-
GTF72_RS16195435857..437034+1178WP_086010879.1IS3-like element ISVch4 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306905..436165129260
insideIntegron--311985..435789123804
flankIS/Tn--428737..429174437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T145820 WP_001114075.1 NZ_CP047296:431444-431713 [Vibrio cholerae C6706]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T145820 NZ_CP062700:3669976-3670362 [Escherichia coli O157:H7]
ATGGGTGTGTATAAGGCAAGGCGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAAGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGGTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAAGCAAAGAAATCGAAGATGATGAACTGGCAGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTCTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT145820 WP_000921691.1 NZ_CP047296:431707-432228 [Vibrio cholerae C6706]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT145820 NZ_CP062700:3670352-3670681 [Escherichia coli O157:H7]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAGGTTGA
TGCCATTGCCGTCATGGTCAAAGCCCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A086SLD6

Antitoxin

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Source
ID
Structure
AlphaFold DBQ9KM84

References