Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 326772..327538 Replicon chromosome
Accession NZ_CP072850
Organism Vibrio cholerae MO10

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag KAF59_RS15270 Protein ID WP_000982260.1
Coordinates 326772..327269 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag KAF59_RS15275 Protein ID WP_000246253.1
Coordinates 327266..327538 (-) Length 91 a.a.

Genomic Context

KAF59_RS15225KAF59_RS15230KAF59_RS15245KAF59_RS15250KAF59_RS15255KAF59_RS15260KAF59_RS15265KAF59_RS18800KAF59_RS15280KAF59_RS15290KAF59_RS18805KAF59_RS15305KAF59_RS18810KAF59_RS15315KAF59_RS15320KAF59_RS15325KAF59_RS15330KAF59_RS15335KAF59_RS15235KAF59_RS15240KAF59_RS15270KAF59_RS15275KAF59_RS15295KAF59_RS15300
Location: 322214..322918 (705 bp)
Type: Others
Protein ID: WP_000087610.1
Location: 323076..323414 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 324390..324776 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 324833..324946 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 324955..325176 (222 bp)
Type: Others
Protein ID: WP_032467793.1
Location: 325434..325970 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 326161..326622 (462 bp)
Type: Others
Protein ID: WP_001903091.1
Location: 326687..326755 (69 bp)
Type: Others
Protein ID: Protein_286
Location: 327931..328056 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 328306..328752 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 329491..329608 (118 bp)
Type: Others
Protein ID: Protein_293
Location: 329726..330004 (279 bp)
Type: Others
Protein ID: WP_001921601.1
Location: 330364..330462 (99 bp)
Type: Others
Protein ID: WP_223225486.1
Location: 330662..330763 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 330753..331139 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 331334..331585 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 331558..331707 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 331799..332041 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 323568..323885 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 323904..324146 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 326772..327269 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 327266..327538 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
Location: 328900..329169 (270 bp)
Type: Others
Protein ID: WP_000277238.1
Location: 329162..329440 (279 bp)
Type: Others
Protein ID: WP_001258569.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KAF59_RS15225 (KAF59_15225)322214..322918+705WP_000087610.1HNH endonuclease-
KAF59_RS15230 (KAF59_15230)323076..323414+339WP_000713853.1hypothetical protein-
KAF59_RS15235 (KAF59_15235)323568..323885-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
KAF59_RS15240 (KAF59_15240)323904..324146-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
KAF59_RS15245 (KAF59_15245)324390..324776+387WP_001015867.1NUDIX hydrolase-
KAF59_RS15250 (KAF59_15250)324833..324946+114WP_001900214.1hypothetical protein-
KAF59_RS15255 (KAF59_15255)324955..325176+222WP_032467793.1DUF1289 domain-containing protein-
KAF59_RS15260 (KAF59_15260)325434..325970+537WP_000469482.1GNAT family protein-
KAF59_RS15265 (KAF59_15265)326161..326622+462WP_001903091.1lipocalin family protein-
KAF59_RS18800326687..326755+69Protein_286acetyltransferase-
KAF59_RS15270 (KAF59_15270)326772..327269-498WP_000982260.1GNAT family N-acetyltransferaseToxin
KAF59_RS15275 (KAF59_15275)327266..327538-273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
KAF59_RS15280 (KAF59_15280)327931..328056+126WP_001900195.1DUF645 family protein-
KAF59_RS15290 (KAF59_15290)328306..328752+447WP_000006157.1hypothetical protein-
KAF59_RS15295 (KAF59_15295)328900..329169-270WP_000277238.1type II toxin-antitoxin system YafQ family toxin-
KAF59_RS15300 (KAF59_15300)329162..329440-279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
KAF59_RS18805329491..329608+118Protein_293DUF3265 domain-containing protein-
KAF59_RS15305 (KAF59_15305)329726..330004+279WP_001921601.1DUF3709 domain-containing protein-
KAF59_RS18810330364..330462+99WP_223225486.1DUF3709 domain-containing protein-
KAF59_RS15315 (KAF59_15315)330662..330763+102WP_001921603.1hypothetical protein-
KAF59_RS15320 (KAF59_15320)330753..331139+387WP_000703163.1VOC family protein-
KAF59_RS15325 (KAF59_15325)331334..331585+252WP_001890111.1TIGR03643 family protein-
KAF59_RS15330 (KAF59_15330)331558..331707+150WP_071908333.1DUF3265 domain-containing protein-
KAF59_RS15335 (KAF59_15335)331799..332041+243WP_000107461.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306928..40218995261
insideIntegroncatB9-312008..40181389805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T198999 WP_000982260.1 NZ_CP072850:c327269-326772 [Vibrio cholerae MO10]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T198999 NZ_CP097082:c5145045-5144662 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT198999 WP_000246253.1 NZ_CP072850:c327538-327266 [Vibrio cholerae MO10]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT198999 NZ_CP097082:c5145287-5145045 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References