198999

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 326772..327538 Replicon chromosome
Accession NZ_CP072850
Organism Vibrio cholerae MO10

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag KAF59_RS15270 Protein ID WP_000982260.1
Coordinates 326772..327269 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag KAF59_RS15275 Protein ID WP_000246253.1
Coordinates 327266..327538 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAF59_RS15225 (KAF59_15225) 322214..322918 + 705 WP_000087610.1 HNH endonuclease -
KAF59_RS15230 (KAF59_15230) 323076..323414 + 339 WP_000713853.1 hypothetical protein -
KAF59_RS15235 (KAF59_15235) 323568..323885 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
KAF59_RS15240 (KAF59_15240) 323904..324146 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
KAF59_RS15245 (KAF59_15245) 324390..324776 + 387 WP_001015867.1 NUDIX hydrolase -
KAF59_RS15250 (KAF59_15250) 324833..324946 + 114 WP_001900214.1 hypothetical protein -
KAF59_RS15255 (KAF59_15255) 324955..325176 + 222 WP_032467793.1 DUF1289 domain-containing protein -
KAF59_RS15260 (KAF59_15260) 325434..325970 + 537 WP_000469482.1 GNAT family protein -
KAF59_RS15265 (KAF59_15265) 326161..326622 + 462 WP_001903091.1 lipocalin family protein -
KAF59_RS18800 326687..326755 + 69 Protein_286 acetyltransferase -
KAF59_RS15270 (KAF59_15270) 326772..327269 - 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
KAF59_RS15275 (KAF59_15275) 327266..327538 - 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
KAF59_RS15280 (KAF59_15280) 327931..328056 + 126 WP_001900195.1 DUF645 family protein -
KAF59_RS15290 (KAF59_15290) 328306..328752 + 447 WP_000006157.1 hypothetical protein -
KAF59_RS15295 (KAF59_15295) 328900..329169 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
KAF59_RS15300 (KAF59_15300) 329162..329440 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
KAF59_RS18805 329491..329608 + 118 Protein_293 DUF3265 domain-containing protein -
KAF59_RS15305 (KAF59_15305) 329726..330004 + 279 WP_001921601.1 DUF3709 domain-containing protein -
KAF59_RS18810 330364..330462 + 99 WP_223225486.1 DUF3709 domain-containing protein -
KAF59_RS15315 (KAF59_15315) 330662..330763 + 102 WP_001921603.1 hypothetical protein -
KAF59_RS15320 (KAF59_15320) 330753..331139 + 387 WP_000703163.1 VOC family protein -
KAF59_RS15325 (KAF59_15325) 331334..331585 + 252 WP_001890111.1 TIGR03643 family protein -
KAF59_RS15330 (KAF59_15330) 331558..331707 + 150 WP_071908333.1 DUF3265 domain-containing protein -
KAF59_RS15335 (KAF59_15335) 331799..332041 + 243 WP_000107461.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306928..402189 95261
inside Integron catB9 - 312008..401813 89805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T198999 WP_000982260.1 NZ_CP072850:c327269-326772 [Vibrio cholerae MO10]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T198999 NZ_CP097082:c5145045-5144662 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT198999 WP_000246253.1 NZ_CP072850:c327538-327266 [Vibrio cholerae MO10]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT198999 NZ_CP097082:c5145287-5145045 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References