48160

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) dhiT-phd/-
Location 405036..405440 Replicon chromosome
Accession NZ_CP009041
Organism Vibrio cholerae O1 biovar El Tor strain FJ147

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag IR04_RS02085 Protein ID WP_001114075.1
Coordinates 405171..405440 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag IR04_RS20045 Protein ID WP_099607150.1
Coordinates 405036..405140 (+) Length 35 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IR04_RS02050 400537..401454 + 918 WP_000186333.1 alpha/beta hydrolase -
IR04_RS02055 401611..402000 + 390 WP_001081302.1 hypothetical protein -
IR04_RS02060 402136..402345 + 210 Protein_424 GNAT family N-acetyltransferase -
IR04_RS02065 402464..402901 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
IR04_RS02070 402965..403183 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
IR04_RS02075 403358..404230 + 873 WP_000254716.1 DUF3800 domain-containing protein -
IR04_RS02080 404380..404979 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
IR04_RS20045 405036..405140 + 105 WP_099607150.1 acetyltransferase Antitoxin
IR04_RS02085 405171..405440 + 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
IR04_RS02090 405434..405955 + 522 WP_000921691.1 DUF2442 domain-containing protein -
IR04_RS20050 406254..406379 + 126 WP_001905700.1 DUF645 family protein -
IR04_RS02095 406630..407025 + 396 WP_001000867.1 hypothetical protein -
IR04_RS02100 407164..407442 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
IR04_RS02105 407439..407723 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
IR04_RS02110 407917..408432 + 516 WP_000343779.1 GNAT family N-acetyltransferase -
IR04_RS02115 408616..409029 + 414 WP_000049420.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304700..409892 105192
inside Integron - - 309780..409516 99736
flank IS/Tn - - 402464..402901 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T48160 WP_001114075.1 NZ_CP009041:405171-405440 [Vibrio cholerae O1 biovar El Tor]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T48160 NZ_CP009041:405171-405440 [Vibrio cholerae O1 biovar El Tor]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 35 a.a.        Molecular weight: 3991.79 Da        Isoelectric Point: 9.2853

>AT48160 WP_099607150.1 NZ_CP009041:405036-405140 [Vibrio cholerae O1 biovar El Tor]
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL

Download         Length: 105 bp

>AT48160 NZ_CP009041:405036-405140 [Vibrio cholerae O1 biovar El Tor]
GTGGTTTCGGTTGTTGTGTTTGAGTTTAGTAGTATGCGCTGCCAGCCCCTTAGGCGGGCGTTATATGCTTATAGGAATTG
TCTCCTAAAGGATACGCTGCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure

References