Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-GNAT
Location 275361..276454 Replicon chromosome
Accession NZ_LT992493
Organism Vibrio cholerae strain 4295STDY6534248

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag DG169_RS16075 Protein ID WP_000351248.1
Coordinates 276053..276454 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag DG169_RS16070 Protein ID WP_001047169.1
Coordinates 275361..276053 (+) Length 231 a.a.

Genomic Context

DG169_RS16005DG169_RS19860DG169_RS16010DG169_RS16025DG169_RS16030DG169_RS16045DG169_RS16050DG169_RS16055DG169_RS19685DG169_RS16065DG169_RS16070DG169_RS16075DG169_RS16080DG169_RS16085DG169_RS16090DG169_RS16095DG169_RS16100DG169_RS16105DG169_RS16125DG169_RS16130DG169_RS16060DG169_RS16115DG169_RS16120
Location: 270644..271021 (378 bp)
Type: Others
Protein ID: WP_000411109.1
Location: 271078..271192 (115 bp)
Type: Others
Protein ID: Protein_296
Location: 271141..271422 (282 bp)
Type: Others
Protein ID: WP_001894453.1
Location: 271588..271701 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 271650..271877 (228 bp)
Type: Others
Protein ID: WP_001894457.1
Location: 272218..272550 (333 bp)
Type: Others
Protein ID: WP_000843587.1
Location: 272537..272851 (315 bp)
Type: Others
Protein ID: WP_000071008.1
Location: 272988..273422 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 273590..273745 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 274918..275224 (307 bp)
Type: Others
Protein ID: Protein_305
Location: 275361..276053 (693 bp)
Type: Antitoxin
Protein ID: WP_001047169.1
Location: 276053..276454 (402 bp)
Type: Toxin
Protein ID: WP_000351248.1
Location: 276424..276567 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 276642..277055 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 277269..277520 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 277510..277797 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 277925..278380 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 278702..278854 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 280053..280721 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 280873..281160 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 273870..274850 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 279056..279553 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 279550..279822 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DG169_RS16005270644..271021+378WP_000411109.1hypothetical protein-
DG169_RS19860271078..271192+115Protein_296acetyltransferase-
DG169_RS16010271141..271422+282WP_001894453.1DUF1289 domain-containing protein-
DG169_RS16025271588..271701+114WP_001889158.1hypothetical protein-
DG169_RS16030271650..271877+228WP_001894457.1DUF1289 domain-containing protein-
DG169_RS16045272218..272550+333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxin-
DG169_RS16050272537..272851+315WP_000071008.1DNA-binding transcriptional regulator-
DG169_RS16055272988..273422+435WP_000256036.1GNAT family N-acetyltransferase-
DG169_RS19685273590..273745+156WP_000751734.1hypothetical protein-
DG169_RS16060273870..274850-981WP_000019370.1IS5-like element ISVch5 family transposase-
DG169_RS16065274918..275224+307Protein_305CatB-related O-acetyltransferase-
DG169_RS16070275361..276053+693WP_001047169.1GNAT family N-acetyltransferaseAntitoxin
DG169_RS16075276053..276454+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxinToxin
DG169_RS16080276424..276567+144WP_071908341.1DUF3265 domain-containing protein-
DG169_RS16085276642..277055+414WP_000049417.1VOC family protein-
DG169_RS16090277269..277520+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
DG169_RS16095277510..277797+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
DG169_RS16100277925..278380+456WP_001245327.1GNAT family N-acetyltransferase-
DG169_RS16105278702..278854+153WP_001884520.1DUF645 family protein-
DG169_RS16115279056..279553-498WP_000982260.1GNAT family N-acetyltransferase-
DG169_RS16120279550..279822-273WP_000246253.1DUF1778 domain-containing protein-
DG169_RS16125280053..280721+669WP_000043871.1hypothetical protein-
DG169_RS16130280873..281160+288WP_000426470.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-197768..29303295264
insideIntegroncatB9-202848..29265689808
flankIS/Tn--273870..274850980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin

GNAT domain

(36-153)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T294415 WP_000351248.1 NZ_LT992493:276053-276454 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

Antitoxin


Download         Length: 231 a.a.        Molecular weight: 26352.73 Da        Isoelectric Point: 8.5633

>AT294415 WP_001047169.1 NZ_LT992493:275361-276053 [Vibrio cholerae]
MNLEEFQESDFDLLIKWIDSDELNYLWGCPAYVFPLTYEQIHSHCSKAEVFPYLLKVKGRHAGFVELYKVTDEQYRICRV
FISNAYRGQGLSKSMLMLLIDKARLDFSATKLSLGVFEQNTVARKCYESLGFEVVMVVVIEFGGMRCQPLRRALCFLSRF
GAIIGLTFIDSRCDMNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 693 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0PN34

Antitoxin

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Source
ID
Structure
No matching records found

References