211908

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 942269..942816 Replicon chromosome
Accession NZ_CP080466
Organism Vibrio cholerae strain ICDC-VC3741

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag K1T75_RS17850 Protein ID WP_000229317.1
Coordinates 942269..942571 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag K1T75_RS17855 Protein ID WP_000861987.1
Coordinates 942559..942816 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K1T75_RS17810 937468..937536 - 69 Protein_805 acetyltransferase -
K1T75_RS17815 937593..938192 - 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
K1T75_RS17820 938342..939214 - 873 WP_000254716.1 DUF3800 domain-containing protein -
K1T75_RS17825 939389..939610 - 222 Protein_808 GNAT family N-acetyltransferase -
K1T75_RS17830 939671..940108 - 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
K1T75_RS17835 940227..940436 - 210 Protein_810 GNAT family N-acetyltransferase -
K1T75_RS17840 940572..940961 - 390 WP_001081302.1 hypothetical protein -
K1T75_RS17845 941118..942035 - 918 WP_000186333.1 alpha/beta hydrolase -
K1T75_RS17850 942269..942571 - 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K1T75_RS17855 942559..942816 - 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K1T75_RS18835 942898..943008 - 111 WP_086010065.1 DUF3265 domain-containing protein -
K1T75_RS17860 943018..943551 - 534 WP_000118351.1 GNAT family N-acetyltransferase -
K1T75_RS18840 943548..943817 - 270 WP_000179600.1 DUF1778 domain-containing protein -
K1T75_RS17870 944040..944411 - 372 WP_001164080.1 MazG nucleotide pyrophosphohydrolase domain-containing protein -
K1T75_RS17875 944552..944839 - 288 WP_000426470.1 hypothetical protein -
K1T75_RS17880 944991..945659 - 669 WP_000043871.1 hypothetical protein -
K1T75_RS18845 945676..945738 - 63 Protein_821 acetyltransferase -
K1T75_RS17885 945890..946162 + 273 WP_000246253.1 DUF1778 domain-containing protein -
K1T75_RS17890 946159..946656 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
K1T75_RS18850 946673..946741 - 69 Protein_824 acetyltransferase -
K1T75_RS17895 946858..946962 - 105 WP_228840819.1 DUF645 family protein -
K1T75_RS18855 947153..947275 - 123 Protein_826 acetyltransferase -
K1T75_RS17900 947332..947787 - 456 WP_001245327.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 932680..1039634 106954
inside Integron - - 933056..1032792 99736
flank IS/Tn - - 939671..940108 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T211908 WP_000229317.1 NZ_CP080466:c942571-942269 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T211908 NZ_CP106838:2868707-2869192 [Klebsiella michiganensis]
ATGATCTCCGCCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATGGATAACTG
GCTGAAACAGCGGGCGATGAAAAACCAGCTTTCTGGCGCGTCCCGTACGTTTGTCTGCTGCCACGATGCTAAGGTGATGG
CTTACTACTCGCTGGCGTCCAGCGCGGTAACGACAAACACCGCCCCCGGCCGCTTTCGTCGCAATATGCCCGATCCGATC
CCGGTTGTAGTGCTGGGACGTCTGGCGGTGGATCGGTCGCTACATGGACAAGGCGTTGGGCGGGCGCTGGTGAGGGATGC
CGGACTGCGGGTGATTCAGGTGGCGGAAACTATCGGTATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGCGGG
AGTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT211908 WP_000861987.1 NZ_CP080466:c942816-942559 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT211908 NZ_CP106838:2868417-2868710 [Klebsiella michiganensis]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACTCTGAACCTGCGCATCAGGCCCGCTGAGCGCGATCTTATCGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGTTGA
TTGAGCAACGCATTATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTGGCTCGCCTGGATCAGACTCCTGCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9KM92

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References