145804

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 326749..327515 Replicon chromosome
Accession NZ_CP047296
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag GTF72_RS15190 Protein ID WP_000982260.1
Coordinates 326749..327246 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag GTF72_RS15195 Protein ID WP_000246253.1
Coordinates 327243..327515 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF72_RS15140 322191..322895 + 705 WP_000087610.1 HNH endonuclease -
GTF72_RS15145 323053..323391 + 339 WP_000713853.1 hypothetical protein -
GTF72_RS15150 323545..323862 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
GTF72_RS15155 323881..324123 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GTF72_RS15160 324367..324753 + 387 WP_001015867.1 NUDIX hydrolase -
GTF72_RS15165 324810..324923 + 114 WP_001900214.1 hypothetical protein -
GTF72_RS15170 324872..325153 + 282 WP_001894429.1 DUF1289 domain-containing protein -
GTF72_RS15175 325129..325287 - 159 WP_001886450.1 DUF1196 family protein -
GTF72_RS15180 325411..325947 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
GTF72_RS15185 326084..326599 + 516 WP_001201509.1 lipocalin family protein -
GTF72_RS15190 326749..327246 - 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
GTF72_RS15195 327243..327515 - 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
GTF72_RS15200 327908..328033 + 126 WP_001900195.1 DUF645 family protein -
GTF72_RS15205 328049..328087 + 39 WP_106019118.1 hypothetical protein -
GTF72_RS15210 328283..328729 + 447 WP_000006157.1 hypothetical protein -
GTF72_RS15215 328877..329146 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
GTF72_RS15220 329139..329417 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
GTF72_RS15225 329703..329981 + 279 WP_001921601.1 DUF3709 domain-containing protein -
GTF72_RS15230 330233..330439 + 207 Protein_294 DUF3709 domain-containing protein -
GTF72_RS15235 330639..330740 + 102 WP_001921603.1 hypothetical protein -
GTF72_RS15240 330730..331116 + 387 WP_000703163.1 VOC family protein -
GTF72_RS15245 331311..331562 + 252 WP_001890111.1 TIGR03643 family protein -
GTF72_RS15250 331535..331684 + 150 WP_071908333.1 DUF3265 domain-containing protein -
GTF72_RS15255 331776..332018 + 243 WP_000107461.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306905..436165 129260
inside Integron - - 311985..435789 123804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T145804 WP_000982260.1 NZ_CP047296:c327246-326749 [Vibrio cholerae C6706]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T145804 NZ_CP062700:396395-396922 [Escherichia coli O157:H7]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATAAATCGCTGGGCTTTATCCCTTTAGTCGGGGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT145804 WP_000246253.1 NZ_CP047296:c327515-327243 [Vibrio cholerae C6706]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT145804 NZ_CP062700:396122-396388 [Escherichia coli O157:H7]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References