Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 422651..423606 Replicon chromosome
Accession NZ_CP024163
Organism Vibrio cholerae strain E7946

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag CSW01_RS16770 Protein ID WP_000118351.1
Coordinates 423073..423606 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag CSW01_RS20000 Protein ID WP_001882332.1
Coordinates 422651..423076 (+) Length 142 a.a.

Genomic Context

CSW01_RS16710CSW01_RS16715CSW01_RS16720CSW01_RS16725CSW01_RS16750CSW01_RS16755CSW01_RS16760CSW01_RS20000CSW01_RS16770CSW01_RS16780CSW01_RS16785CSW01_RS16790CSW01_RS16795CSW01_RS16800CSW01_RS16805CSW01_RS16810CSW01_RS16815CSW01_RS16735CSW01_RS16740
Location: 418181..418432 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 418422..418709 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 418837..419292 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 419614..419766 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 420965..421633 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 421785..422072 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 422213..422584 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 422651..423076 (426 bp)
Type: Antitoxin
Protein ID: WP_001882332.1
Location: 423073..423606 (534 bp)
Type: Toxin
Protein ID: WP_000118351.1
Location: 423808..424065 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 424053..424355 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 424589..425506 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 425663..426052 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 426188..426397 (210 bp)
Type: Others
Protein ID: Protein_463
Location: 426516..426953 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 427017..427235 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 427410..428282 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 419968..420465 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 420462..420734 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CSW01_RS16710418181..418432+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
CSW01_RS16715418422..418709+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
CSW01_RS16720418837..419292+456WP_001245327.1GNAT family N-acetyltransferase-
CSW01_RS16725419614..419766+153WP_001884520.1DUF645 family protein-
CSW01_RS16735419968..420465-498WP_000982260.1GNAT family N-acetyltransferase-
CSW01_RS16740420462..420734-273WP_000246253.1DUF1778 domain-containing protein-
CSW01_RS16750420965..421633+669WP_000043871.1hypothetical protein-
CSW01_RS16755421785..422072+288WP_000426470.1hypothetical protein-
CSW01_RS16760422213..422584+372WP_001164080.1nucleotide pyrophosphohydrolase-
CSW01_RS20000422651..423076+426WP_001882332.1DUF1778 domain-containing proteinAntitoxin
CSW01_RS16770423073..423606+534WP_000118351.1GNAT family N-acetyltransferaseToxin
CSW01_RS16780423808..424065+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
CSW01_RS16785424053..424355+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
CSW01_RS16790424589..425506+918WP_000186333.1alpha/beta hydrolase-
CSW01_RS16795425663..426052+390WP_001081302.1hypothetical protein-
CSW01_RS16800426188..426397+210Protein_463GNAT family N-acetyltransferase-
CSW01_RS16805426516..426953+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
CSW01_RS16810427017..427235+219WP_071908318.1GNAT family N-acetyltransferase-
CSW01_RS16815427410..428282+873WP_000254716.1DUF3800 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304226..433944129718
insideIntegron--309306..433568124262
flankIS/Tn--426516..426953437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(57-133)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T87029 WP_000118351.1 NZ_CP024163:423073-423606 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T87029 NZ_CP024163:423073-423606 [Vibrio cholerae]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGCCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATACGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15714.41 Da        Isoelectric Point: 7.6659

>AT87029 WP_001882332.1 NZ_CP024163:422651-423076 [Vibrio cholerae]
MLCLSLVVMRCQPLRRALYSPSPRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLK
SLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK

Download         Length: 426 bp

>AT87029 NZ_CP024163:422651-423076 [Vibrio cholerae]
TTGTTGTGTTTGAGTTTAGTGGTCATGCGTTGTCAGCCCCTTAGACGGGCGTTATATTCTCCCTCGCCCCGTAAACTTTC
CGTACGAATTGAATGTGCTTTAAGTTTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTACGCAGGAGGGGTTATGG
CAACGGCACGTTTAGATATCCGCCTTGATGAAGAGATCAAGGCAAAAGCTGAAAAGGCATCGGCTTTACTTGGTTTAAAA
AGTCTCACTGAATATGTGGTGAGACTTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGGTTAA
AGACAGTGTTTTTGACGAGTTTATGGCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAAT
TTACAGAGAAGAGCGGTATCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM94

Antitoxin

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Source
ID
Structure
No matching records found

References