87029

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 422651..423606 Replicon chromosome
Accession NZ_CP024163
Organism Vibrio cholerae strain E7946

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag CSW01_RS16770 Protein ID WP_000118351.1
Coordinates 423073..423606 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag CSW01_RS20000 Protein ID WP_001882332.1
Coordinates 422651..423076 (+) Length 142 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSW01_RS16710 418181..418432 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
CSW01_RS16715 418422..418709 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
CSW01_RS16720 418837..419292 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
CSW01_RS16725 419614..419766 + 153 WP_001884520.1 DUF645 family protein -
CSW01_RS16735 419968..420465 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
CSW01_RS16740 420462..420734 - 273 WP_000246253.1 DUF1778 domain-containing protein -
CSW01_RS16750 420965..421633 + 669 WP_000043871.1 hypothetical protein -
CSW01_RS16755 421785..422072 + 288 WP_000426470.1 hypothetical protein -
CSW01_RS16760 422213..422584 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
CSW01_RS20000 422651..423076 + 426 WP_001882332.1 DUF1778 domain-containing protein Antitoxin
CSW01_RS16770 423073..423606 + 534 WP_000118351.1 GNAT family N-acetyltransferase Toxin
CSW01_RS16780 423808..424065 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
CSW01_RS16785 424053..424355 + 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin -
CSW01_RS16790 424589..425506 + 918 WP_000186333.1 alpha/beta hydrolase -
CSW01_RS16795 425663..426052 + 390 WP_001081302.1 hypothetical protein -
CSW01_RS16800 426188..426397 + 210 Protein_463 GNAT family N-acetyltransferase -
CSW01_RS16805 426516..426953 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
CSW01_RS16810 427017..427235 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
CSW01_RS16815 427410..428282 + 873 WP_000254716.1 DUF3800 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304226..433944 129718
inside Integron - - 309306..433568 124262
flank IS/Tn - - 426516..426953 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(97-153)

Antitoxin

(57-133)


Sequences


Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T87029 WP_000118351.1 NZ_CP024163:423073-423606 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T87029 NZ_CP024163:423073-423606 [Vibrio cholerae]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGCCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATACGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15714.41 Da        Isoelectric Point: 7.6659

>AT87029 WP_001882332.1 NZ_CP024163:422651-423076 [Vibrio cholerae]
MLCLSLVVMRCQPLRRALYSPSPRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLK
SLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK

Download         Length: 426 bp

>AT87029 NZ_CP024163:422651-423076 [Vibrio cholerae]
TTGTTGTGTTTGAGTTTAGTGGTCATGCGTTGTCAGCCCCTTAGACGGGCGTTATATTCTCCCTCGCCCCGTAAACTTTC
CGTACGAATTGAATGTGCTTTAAGTTTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTACGCAGGAGGGGTTATGG
CAACGGCACGTTTAGATATCCGCCTTGATGAAGAGATCAAGGCAAAAGCTGAAAAGGCATCGGCTTTACTTGGTTTAAAA
AGTCTCACTGAATATGTGGTGAGACTTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGGTTAA
AGACAGTGTTTTTGACGAGTTTATGGCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAAT
TTACAGAGAAGAGCGGTATCAAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB Q9KM94


Antitoxin

Source ID Structure

References