Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 366990..367605 Replicon chromosome
Accession NZ_CP025937
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name higB Uniprot ID Q9KMG5
Locus tag C1H56_RS16200 Protein ID WP_001162670.1
Coordinates 366990..367277 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C1H56_RS16205 Protein ID WP_001232701.1
Coordinates 367288..367605 (+) Length 106 a.a.

Genomic Context

C1H56_RS19960C1H56_RS16170C1H56_RS16175C1H56_RS16180C1H56_RS16185C1H56_RS16190C1H56_RS16200C1H56_RS16205C1H56_RS19965C1H56_RS16220C1H56_RS19855C1H56_RS19970C1H56_RS16230C1H56_RS16235C1H56_RS16240C1H56_RS16250C1H56_RS16255C1H56_RS16160C1H56_RS16165
Location: 362626..362721 (96 bp)
Type: Others
Protein ID: WP_001907607.1
Location: 363735..364244 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 364301..364954 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 365264..365482 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 365885..366118 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 366543..366723 (181 bp)
Type: Others
Protein ID: Protein_360
Location: 366990..367277 (288 bp)
Type: Toxin
Protein ID: WP_001162670.1
Location: 367288..367605 (318 bp)
Type: Antitoxin
Protein ID: WP_001232701.1
Location: 367602..367712 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 367889..368014 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 368030..368068 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 368145..368246 (102 bp)
Type: Others
Protein ID: Protein_366
Location: 368292..369032 (741 bp)
Type: Others
Protein ID: WP_000469836.1
Location: 369237..370067 (831 bp)
Type: Others
Protein ID: WP_000056616.1
Location: 370124..370606 (483 bp)
Type: Others
Protein ID: WP_001895003.1
Location: 371053..371928 (876 bp)
Type: Others
Protein ID: WP_000259044.1
Location: 372058..372513 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 362915..363232 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 363251..363493 (243 bp)
Type: Others
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
C1H56_RS19960362626..362721+96WP_001907607.1DUF645 family protein-
C1H56_RS16160362915..363232-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
C1H56_RS16165363251..363493-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
C1H56_RS16170363735..364244+510WP_000405987.1GNAT family N-acetyltransferase-
C1H56_RS16175364301..364954+654WP_000226874.1hypothetical protein-
C1H56_RS16180365264..365482+219WP_001917086.1DUF3709 domain-containing protein-
C1H56_RS16185365885..366118+234WP_032482776.1DUF3709 domain-containing protein-
C1H56_RS16190366543..366723+181Protein_360DUF645 family protein-
C1H56_RS16200366990..367277+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxinToxin
C1H56_RS16205367288..367605+318WP_001232701.1HigA family addiction module antidote proteinAntitoxin
C1H56_RS19965367602..367712+111WP_134814058.1DUF3265 domain-containing protein-
C1H56_RS16220367889..368014+126WP_001944767.1DUF645 family protein-
C1H56_RS19855368030..368068+39WP_106019119.1hypothetical protein-
C1H56_RS19970368145..368246+102Protein_366exlusion protein FxsA-
C1H56_RS16230368292..369032+741WP_000469836.1PhzF family phenazine biosynthesis protein-
C1H56_RS16235369237..370067+831WP_000056616.1abortive infection family protein-
C1H56_RS16240370124..370606+483WP_001895003.1hypothetical protein-
C1H56_RS16250371053..371928+876WP_000259044.1hypothetical protein-
C1H56_RS16255372058..372513+456WP_001245327.1GNAT family N-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304067..433328129261
insideIntegroncatB9-309147..432952123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11349.95 Da        Isoelectric Point: 6.7187

>T92509 WP_001162670.1 NZ_CP025937:366990-367277 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Download         Length: 288 bp

>T92509 NZ_CP025937:366990-367277 [Vibrio cholerae]
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11705.63 Da        Isoelectric Point: 10.4711

>AT92509 WP_001232701.1 NZ_CP025937:367288-367605 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Download         Length: 318 bp

>AT92509 NZ_CP025937:367288-367605 [Vibrio cholerae]
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTCAGTAATTTAATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCCGCGGCATTAGGTAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F2HI36

Antitoxin

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Source
ID
Structure
No matching records found

References