74628

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 850402..850900 Replicon chromosome
Accession NZ_CP020407
Organism Vibrio cholerae strain FDAARGOS_223

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag A6J62_RS04405 Protein ID WP_000589156.1
Coordinates 850634..850900 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag A6J62_RS04400 Protein ID WP_000643598.1
Coordinates 850402..850647 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6J62_RS04355 845483..845869 - 387 WP_000703163.1 VOC family protein -
A6J62_RS04360 846026..846532 - 507 WP_000393074.1 hypothetical protein -
A6J62_RS04365 846800..847033 - 234 WP_001890112.1 DUF3709 domain-containing protein -
A6J62_RS04370 847306..847665 - 360 WP_001071541.1 VOC family protein -
A6J62_RS04375 847818..848822 - 1005 WP_000964920.1 LD-carboxypeptidase -
A6J62_RS04380 849038..849220 - 183 WP_000923182.1 DUF645 family protein -
A6J62_RS04385 849281..849409 - 129 WP_071908338.1 general secretion pathway protein GspI -
A6J62_RS04395 849512..850306 - 795 WP_001911581.1 hypothetical protein -
A6J62_RS04400 850402..850647 - 246 WP_000643598.1 hypothetical protein Antitoxin
A6J62_RS04405 850634..850900 - 267 WP_000589156.1 BrnT family toxin Toxin
A6J62_RS04415 851085..851747 - 663 WP_000960654.1 hypothetical protein -
A6J62_RS04420 851875..852342 - 468 WP_001289288.1 OsmC family protein -
A6J62_RS19680 852554..852592 - 39 WP_082798268.1 hypothetical protein -
A6J62_RS19685 852646..852789 - 144 Protein_814 DUF645 family protein -
A6J62_RS04445 853164..853442 - 279 WP_000280324.1 DUF3709 domain-containing protein -
A6J62_RS04450 853694..853936 - 243 WP_000107461.1 hypothetical protein -
A6J62_RS04455 854028..854177 - 150 WP_071908333.1 DUF3265 domain-containing protein -
A6J62_RS04460 854150..854401 - 252 WP_001890111.1 TIGR03643 family protein -
A6J62_RS04465 854596..854982 - 387 WP_000703163.1 VOC family protein -
A6J62_RS04470 854972..855073 - 102 WP_001921603.1 hypothetical protein -
A6J62_RS19590 855273..855479 - 207 Protein_821 DUF3709 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 749087..881909 132822
inside Integron - - 749463..875103 125640


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T74628 WP_000589156.1 NZ_CP020407:c850900-850634 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T74628 NZ_CP020407:c850900-850634 [Vibrio cholerae]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
ATTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT74628 WP_000643598.1 NZ_CP020407:c850647-850402 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT74628 NZ_CP020407:c850647-850402 [Vibrio cholerae]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A271VMP7

Antitoxin

Source ID Structure
AlphaFold DB A0A271VME2

References