Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/RelE-RelB |
Location | 332192..332751 | Replicon | chromosome |
Accession | NZ_CP013306 | ||
Organism | Vibrio cholerae strain CRC1106 |
Toxin (Protein)
Gene name | relE | Uniprot ID | Q9K2M8 |
Locus tag | ASZ81_RS15800 | Protein ID | WP_000578476.1 |
Coordinates | 332192..332470 (-) | Length | 93 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | Q9L991 |
Locus tag | ASZ81_RS15805 | Protein ID | WP_000381183.1 |
Coordinates | 332467..332751 (-) | Length | 95 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
ASZ81_RS15755 | 328132..328314 | + | 183 | WP_000923340.1 | DUF645 family protein | - |
ASZ81_RS15760 | 328529..329068 | + | 540 | WP_000099372.1 | hypothetical protein | - |
ASZ81_RS15765 | 329191..329706 | + | 516 | WP_000090011.1 | hypothetical protein | - |
ASZ81_RS15770 | 329841..330377 | + | 537 | WP_000644491.1 | nucleotidyltransferase family protein | - |
ASZ81_RS15775 | 330846..330956 | + | 111 | WP_071908335.1 | DUF3265 domain-containing protein | - |
ASZ81_RS15785 | 331169..331321 | + | 153 | WP_001884520.1 | DUF645 family protein | - |
ASZ81_RS15790 | 331605..332048 | + | 444 | WP_000803902.1 | hypothetical protein | - |
ASZ81_RS15795 | 332052..332162 | + | 111 | WP_071908336.1 | DUF3265 domain-containing protein | - |
ASZ81_RS15800 | 332192..332470 | - | 279 | WP_000578476.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
ASZ81_RS15805 | 332467..332751 | - | 285 | WP_000381183.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
ASZ81_RS15815 | 332927..333226 | - | 300 | WP_000802136.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
ASZ81_RS15820 | 333223..333465 | - | 243 | WP_001107719.1 | type II toxin-antitoxin system ParD family antitoxin | - |
ASZ81_RS15830 | 333884..333961 | + | 78 | WP_071908337.1 | DUF645 family protein | - |
ASZ81_RS20835 | 333965..333991 | + | 27 | Protein_298 | hypothetical protein | - |
ASZ81_RS20915 | 334577..334720 | + | 144 | WP_001900215.1 | hypothetical protein | - |
ASZ81_RS20415 | 334814..334993 | + | 180 | Protein_300 | DUF645 family protein | - |
ASZ81_RS15855 | 335211..335639 | + | 429 | WP_000620002.1 | N-acetyltransferase | - |
ASZ81_RS15865 | 336227..336709 | + | 483 | WP_000422940.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | catB9 | - | 304741..463550 | 158809 | |
inside | Integron | - | - | 309821..463174 | 153353 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10819.59 Da Isoelectric Point: 5.1651
>T58259 WP_000578476.1 NZ_CP013306:c332470-332192 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
Download Length: 279 bp
>T58259 NZ_CP013306:c332470-332192 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10901.25 Da Isoelectric Point: 8.0775
>AT58259 WP_000381183.1 NZ_CP013306:c332751-332467 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA
Download Length: 285 bp
>AT58259 NZ_CP013306:c332751-332467 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | Q9K2M8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A067BL33 |