Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 333867..334365 Replicon chromosome
Accession NZ_CP047060
Organism Vibrio cholerae isolate CTMA_1441

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag GQX72_RS15320 Protein ID WP_000589156.1
Coordinates 333867..334133 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag GQX72_RS15325 Protein ID WP_000643598.1
Coordinates 334120..334365 (+) Length 82 a.a.

Genomic Context

GQX72_RS15270GQX72_RS15275GQX72_RS15280GQX72_RS15285GQX72_RS15290GQX72_RS15295GQX72_RS15300GQX72_RS19015GQX72_RS19020GQX72_RS15310GQX72_RS15315GQX72_RS15320GQX72_RS15325GQX72_RS15330GQX72_RS19025GQX72_RS15335GQX72_RS15340GQX72_RS15345GQX72_RS15350GQX72_RS15355GQX72_RS15360
Location: 329288..329494 (207 bp)
Type: Others
Protein ID: Protein_290
Location: 329694..329795 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 329785..330171 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 330366..330617 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 330590..330739 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 330831..331073 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 331325..331603 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 331978..332121 (144 bp)
Type: Others
Protein ID: Protein_297
Location: 332175..332213 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 332425..332892 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 333020..333682 (663 bp)
Type: Others
Protein ID: WP_000960654.1
Location: 333867..334133 (267 bp)
Type: Toxin
Protein ID: WP_000589156.1
Location: 334120..334365 (246 bp)
Type: Antitoxin
Protein ID: WP_000643598.1
Location: 334461..335253 (793 bp)
Type: Others
Protein ID: Protein_303
Location: 335356..335484 (129 bp)
Type: Others
Protein ID: WP_071908338.1
Location: 335545..335727 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 335943..336947 (1005 bp)
Type: Others
Protein ID: WP_000964920.1
Location: 337100..337459 (360 bp)
Type: Others
Protein ID: WP_001071541.1
Location: 337732..337965 (234 bp)
Type: Others
Protein ID: WP_001890112.1
Location: 338233..338739 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 338896..339282 (387 bp)
Type: Others
Protein ID: WP_000703163.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GQX72_RS15270329288..329494+207Protein_290DUF3709 domain-containing protein-
GQX72_RS15275329694..329795+102WP_001921603.1hypothetical protein-
GQX72_RS15280329785..330171+387WP_000703163.1VOC family protein-
GQX72_RS15285330366..330617+252WP_001890111.1TIGR03643 family protein-
GQX72_RS15290330590..330739+150WP_071908333.1DUF3265 domain-containing protein-
GQX72_RS15295330831..331073+243WP_000107461.1hypothetical protein-
GQX72_RS15300331325..331603+279WP_000280324.1DUF3709 domain-containing protein-
GQX72_RS19015331978..332121+144Protein_297DUF645 family protein-
GQX72_RS19020332175..332213+39WP_082798268.1hypothetical protein-
GQX72_RS15310332425..332892+468WP_001289288.1OsmC family protein-
GQX72_RS15315333020..333682+663WP_000960654.1hypothetical protein-
GQX72_RS15320333867..334133+267WP_000589156.1BrnT family toxinToxin
GQX72_RS15325334120..334365+246WP_000643598.1hypothetical proteinAntitoxin
GQX72_RS15330334461..335253+793Protein_303hypothetical protein-
GQX72_RS19025335356..335484+129WP_071908338.1general secretion pathway protein GspI-
GQX72_RS15335335545..335727+183WP_000923182.1DUF645 family protein-
GQX72_RS15340335943..336947+1005WP_000964920.1LD-carboxypeptidase-
GQX72_RS15345337100..337459+360WP_001071541.1VOC family protein-
GQX72_RS15350337732..337965+234WP_001890112.1DUF3709 domain-containing protein-
GQX72_RS15355338233..338739+507WP_000393074.1hypothetical protein-
GQX72_RS15360338896..339282+387WP_000703163.1VOC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-305960..411159105199
insideIntegron--311040..41078399743


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T145395 WP_000589156.1 NZ_CP047060:333867-334133 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T145395 NZ_CP062372:c2021985-2021623 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT145395 WP_000643598.1 NZ_CP047060:334120-334365 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT145395 NZ_CP062372:c2022152-2021982 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A271VMP7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A271VME2

References