Detailed information of TA system TA145395

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /BrnT(toxin)
• Location: 333867..334365
• Replicon: chromosome
• Accession: NZ_CP047060
• Organism: Vibrio cholerae isolate CTMA_1441

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9KMK7
• Locus tag: GQX72_RS15320
• Protein ID: WP_000589156.1
• Coordinates: 333867..334133 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q9KMK6
• Locus tag: GQX72_RS15325
• Protein ID: WP_000643598.1
• Coordinates: 334120..334365 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GQX72_RS15270	329288..329494	+	207	Protein_290	DUF3709 domain-containing protein	-
GQX72_RS15275	329694..329795	+	102	WP_001921603.1	hypothetical protein	-
GQX72_RS15280	329785..330171	+	387	WP_000703163.1	VOC family protein	-
GQX72_RS15285	330366..330617	+	252	WP_001890111.1	TIGR03643 family protein	-
GQX72_RS15290	330590..330739	+	150	WP_071908333.1	DUF3265 domain-containing protein	-
GQX72_RS15295	330831..331073	+	243	WP_000107461.1	hypothetical protein	-
GQX72_RS15300	331325..331603	+	279	WP_000280324.1	DUF3709 domain-containing protein	-
GQX72_RS19015	331978..332121	+	144	Protein_297	DUF645 family protein	-
GQX72_RS19020	332175..332213	+	39	WP_082798268.1	hypothetical protein	-
GQX72_RS15310	332425..332892	+	468	WP_001289288.1	OsmC family protein	-
GQX72_RS15315	333020..333682	+	663	WP_000960654.1	hypothetical protein	-
GQX72_RS15320	333867..334133	+	267	WP_000589156.1	BrnT family toxin	Toxin
GQX72_RS15325	334120..334365	+	246	WP_000643598.1	hypothetical protein	Antitoxin
GQX72_RS15330	334461..335253	+	793	Protein_303	hypothetical protein	-
GQX72_RS19025	335356..335484	+	129	WP_071908338.1	general secretion pathway protein GspI	-
GQX72_RS15335	335545..335727	+	183	WP_000923182.1	DUF645 family protein	-
GQX72_RS15340	335943..336947	+	1005	WP_000964920.1	LD-carboxypeptidase	-
GQX72_RS15345	337100..337459	+	360	WP_001071541.1	VOC family protein	-
GQX72_RS15350	337732..337965	+	234	WP_001890112.1	DUF3709 domain-containing protein	-
GQX72_RS15355	338233..338739	+	507	WP_000393074.1	hypothetical protein	-
GQX72_RS15360	338896..339282	+	387	WP_000703163.1	VOC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	305960..411159	105199
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 Integron TA000164, TA000169, TA000166, TA000167, TA000179, TA000170, TA000171, TA000172, TA000173, TA000174, TA000175, TA000176, TA000177, TA000178, TA000168, TA000165, TA010030, TA010035 309750..435387 0.004	inside	Integron	-	-	311040..410783	99743

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (6-81)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10092.34 Da
• Isoelectric Point: 7.3171

>T145395 WP_000589156.1 NZ_CP047060:333867-334133 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Nucleotide

• Length: 267 bp

>T145395 NZ_CP062372:c2021985-2021623 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9478.77 Da
• Isoelectric Point: 6.4832

>AT145395 WP_000643598.1 NZ_CP047060:334120-334365 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Nucleotide

• Length: 246 bp

>AT145395 NZ_CP062372:c2022152-2021982 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Toxin

• AlphaFold DB: A0A271VMP7

Antitoxin

• AlphaFold DB: A0A271VME2