211919

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 1009467..1009965 Replicon chromosome
Accession NZ_CP080466
Organism Vibrio cholerae strain ICDC-VC3741

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag K1T75_RS18430 Protein ID WP_000589156.1
Coordinates 1009699..1009965 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag K1T75_RS18425 Protein ID WP_000643598.1
Coordinates 1009467..1009712 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K1T75_RS18385 1004548..1004934 - 387 WP_000703163.1 VOC family protein -
K1T75_RS18390 1005091..1005597 - 507 WP_000393074.1 hypothetical protein -
K1T75_RS18965 1006119..1006304 - 186 WP_001999468.1 hypothetical protein -
K1T75_RS18400 1006371..1006730 - 360 WP_001071541.1 VOC family protein -
K1T75_RS18405 1006883..1007887 - 1005 WP_000964920.1 LD-carboxypeptidase -
K1T75_RS18410 1008103..1008285 - 183 WP_000923182.1 DUF645 family protein -
K1T75_RS18415 1008346..1008474 - 129 WP_071908338.1 general secretion pathway protein GspI -
K1T75_RS18970 1008464..1008580 - 117 WP_086010881.1 DUF3265 domain-containing protein -
K1T75_RS18420 1008577..1009371 - 795 WP_001911581.1 hypothetical protein -
K1T75_RS18425 1009467..1009712 - 246 WP_000643598.1 hypothetical protein Antitoxin
K1T75_RS18430 1009699..1009965 - 267 WP_000589156.1 BrnT family toxin Toxin
K1T75_RS18975 1010032..1010160 - 129 WP_088124358.1 DUF3265 domain-containing protein -
K1T75_RS18435 1010150..1010812 - 663 WP_000960654.1 hypothetical protein -
K1T75_RS18440 1010940..1011407 - 468 WP_001289288.1 OsmC family protein -
K1T75_RS18980 1011579..1011710 - 132 WP_001883067.1 hypothetical protein -
K1T75_RS18455 1012229..1012507 - 279 WP_000280324.1 DUF3709 domain-containing protein -
K1T75_RS18460 1012759..1013001 - 243 WP_000107461.1 hypothetical protein -
K1T75_RS18985 1013093..1013242 - 150 WP_071908333.1 DUF3265 domain-containing protein -
K1T75_RS18465 1013215..1013466 - 252 WP_001890111.1 TIGR03643 family protein -
K1T75_RS18470 1013661..1014047 - 387 WP_000703163.1 VOC family protein -
K1T75_RS18475 1014037..1014138 - 102 WP_001921603.1 hypothetical protein -
K1T75_RS18990 1014338..1014436 - 99 WP_223225486.1 DUF3709 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 932680..1039634 106954
inside Integron - - 933056..1032792 99736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T211919 WP_000589156.1 NZ_CP080466:c1009965-1009699 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T211919 NZ_CP106849:1951983-1952264 [Edwardsiella ictaluri]
ATGACCTATAAACTGAGCTTTGAAAAGCGAGCCCTGAAAGAGTGGAAAAAACTGGCACCGCCGATTCAAAGCCAGTTGAA
AAAGAAACTGATCGAACGCCTGGAAAACCCACATGTTCCAGCAGCACGCTTAAGTGGGCGCGCTAACCGTTATAAAATAA
AATTACGCTCTTCCGGTTACCGGTTAGTTTATGAAGTCAACGATAGCGAAATCATCCTGCTGGTGATCGCTATCGGTAAA
CGGGCCGATAACGAGGTGTACCAAGCGGCAGACAGTCGTTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT211919 WP_000643598.1 NZ_CP080466:c1009712-1009467 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT211919 NZ_CP106849:1951742-1951993 [Edwardsiella ictaluri]
ATGGCATACCAAATTCTCACGACCACCGCCGCCAGCATTACCGACCTGAAACGCAATCCAATGGGTACCATTGCTGAAGG
TGACGGCAATGCCGTAGCAATCTTAAACCGGAATGAGCCGGCCTTTTACTGCGTTCCACCGGAACTCTACGCTTACTATC
TGGAGCTGGCTGAAGATGCGGCGCTTAATCGTATCGCCGATGAGCGTCTGGAGGACGCTGAGTTTGTCAGCGTAAATATC
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A271VMP7

Antitoxin

Source ID Structure
AlphaFold DB A0A271VME2

References