145898

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 426615..427162 Replicon chromosome
Accession NZ_CP047304
Organism Vibrio cholerae O1 biovar El Tor strain E7946

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag GTF74_RS16115 Protein ID WP_000229317.1
Coordinates 426860..427162 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag GTF74_RS16110 Protein ID WP_000861987.1
Coordinates 426615..426872 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF74_RS16065 421644..422099 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
GTF74_RS16070 422421..422573 + 153 WP_001884520.1 DUF645 family protein -
GTF74_RS16075 422775..423272 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
GTF74_RS16080 423269..423541 - 273 WP_000246253.1 DUF1778 domain-containing protein -
GTF74_RS16085 423772..424440 + 669 WP_000043871.1 hypothetical protein -
GTF74_RS16090 424592..424879 + 288 WP_000426470.1 hypothetical protein -
GTF74_RS16095 425020..425391 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
GTF74_RS16100 425458..425883 + 426 WP_001882332.1 DUF1778 domain-containing protein -
GTF74_RS16105 425880..426413 + 534 WP_000118351.1 GNAT family N-acetyltransferase -
GTF74_RS16110 426615..426872 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GTF74_RS16115 426860..427162 + 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTF74_RS16120 427396..428313 + 918 WP_000186333.1 alpha/beta hydrolase -
GTF74_RS16125 428470..428859 + 390 WP_001081302.1 hypothetical protein -
GTF74_RS16130 428995..429204 + 210 Protein_472 GNAT family N-acetyltransferase -
GTF74_RS16135 429323..429760 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
GTF74_RS16140 429824..430042 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
GTF74_RS16145 430217..431089 + 873 WP_000254716.1 DUF3800 domain-containing protein -
GTF74_RS16150 431239..431838 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
GTF74_RS16155 431895..431999 + 105 WP_099607150.1 acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 307032..436751 129719
inside Integron - - 312112..436375 124263
flank IS/Tn - - 429323..429760 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T145898 WP_000229317.1 NZ_CP047304:426860-427162 [Vibrio cholerae O1 biovar El Tor]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T145898 NZ_CP062708:c710184-709720 [Escherichia coli O157:H7]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT145898 WP_000861987.1 NZ_CP047304:426615-426872 [Vibrio cholerae O1 biovar El Tor]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT145898 NZ_CP062708:c710519-710184 [Escherichia coli O157:H7]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAGCAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATACAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9KM92

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References