145812

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 399697..400225 Replicon chromosome
Accession NZ_CP047296
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag GTF72_RS15850 Protein ID WP_000221352.1
Coordinates 399697..399987 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag GTF72_RS15855 Protein ID WP_000213183.1
Coordinates 399977..400225 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF72_RS15815 395254..395458 + 205 Protein_411 DUF645 family protein -
GTF72_RS15820 395646..396650 + 1005 WP_000964925.1 LD-carboxypeptidase -
GTF72_RS15825 396803..397249 + 447 WP_000128977.1 hypothetical protein -
GTF72_RS15830 397369..398298 + 930 WP_000335802.1 hypothetical protein -
GTF72_RS15835 398295..398405 + 111 WP_071917832.1 DUF3265 domain-containing protein -
GTF72_RS15840 398433..398909 + 477 WP_001047180.1 GNAT family N-acetyltransferase -
GTF72_RS15845 399046..399561 + 516 WP_001201528.1 lipocalin family protein -
GTF72_RS15850 399697..399987 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTF72_RS15855 399977..400225 - 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GTF72_RS15860 400796..401449 + 654 WP_000036957.1 site-specific DNA-methyltransferase -
GTF72_RS15865 401721..402146 + 426 WP_000415748.1 hypothetical protein -
GTF72_RS15870 402354..402749 + 396 WP_000649527.1 DUF3465 domain-containing protein -
GTF72_RS15875 402900..403430 + 531 WP_000415563.1 hypothetical protein -
GTF72_RS15880 403568..404068 + 501 WP_000789723.1 hypothetical protein -
GTF72_RS15885 404224..404622 + 399 WP_001882293.1 hypothetical protein -
GTF72_RS15890 404722..405186 - 465 WP_000140244.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306905..436165 129260
inside Integron - - 311985..435789 123804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T145812 WP_000221352.1 NZ_CP047296:c399987-399697 [Vibrio cholerae C6706]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T145812 NZ_CP062700:2561434-2561589 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGCTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT145812 WP_000213183.1 NZ_CP047296:c400225-399977 [Vibrio cholerae C6706]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT145812 NZ_CP062700:c2561422-2561364 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACGTGTGTAGAGCATAGATATGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References