Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 415348..415981 Replicon chromosome
Accession NZ_CP047298
Organism Vibrio cholerae O1 biovar El Tor strain C6709

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag GTF73_RS16015 Protein ID WP_000843587.1
Coordinates 415348..415680 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GTF73_RS16020 Protein ID WP_000071008.1
Coordinates 415667..415981 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF73_RS15950 410789..410992 + 204 WP_001911745.1 hypothetical protein -
GTF73_RS15955 411273..411446 + 174 WP_001882305.1 DUF3709 domain-containing protein -
GTF73_RS15960 411806..412075 + 270 WP_001198131.1 hypothetical protein -
GTF73_RS15965 412386..412472 + 87 WP_134820423.1 DUF645 family protein -
GTF73_RS15970 412472..412564 + 93 Protein_437 DUF645 family protein -
GTF73_RS15975 412773..413159 + 387 WP_000703163.1 VOC family protein -
GTF73_RS15980 413361..413603 + 243 WP_000107461.1 hypothetical protein -
GTF73_RS15985 413774..414151 + 378 WP_000411109.1 hypothetical protein -
GTF73_RS15990 414331..414552 + 222 WP_032468461.1 DUF1289 domain-containing protein -
GTF73_RS15995 414528..414686 - 159 WP_001894455.1 DUF1196 family protein -
GTF73_RS16000 414718..414831 + 114 WP_001889158.1 hypothetical protein -
GTF73_RS16005 414780..415007 + 228 WP_001894457.1 DUF1289 domain-containing protein -
GTF73_RS16010 415037..415195 - 159 WP_001882309.1 DUF1196 family protein -
GTF73_RS16015 415348..415680 + 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTF73_RS16020 415667..415981 + 315 WP_000071008.1 DNA-binding transcriptional regulator Antitoxin
GTF73_RS16025 416118..416552 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
GTF73_RS16030 416720..416875 + 156 WP_000751734.1 hypothetical protein -
GTF73_RS16035 417000..417980 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
GTF73_RS16040 418048..418320 + 273 Protein_451 CatB-related O-acetyltransferase -
GTF73_RS16045 418491..419183 + 693 WP_001047169.1 GNAT family N-acetyltransferase -
GTF73_RS16050 419183..419584 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
GTF73_RS16055 419554..419697 + 144 WP_071908341.1 DUF3265 domain-containing protein -
GTF73_RS16060 419772..420185 + 414 WP_000049417.1 VOC family protein -
GTF73_RS16065 420399..420650 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GTF73_RS16070 420640..420927 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306901..436162 129261
inside Integron - - 311981..435786 123805
flank IS/Tn - - 417000..417980 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T145833 WP_000843587.1 NZ_CP047298:415348-415680 [Vibrio cholerae O1 biovar El Tor]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

>T145833 NZ_CP062702:403407-403934 [Escherichia coli O157:H7]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATAAATCGCTGGGCTTTATCCCTTTAGTCGGGGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT145833 WP_000071008.1 NZ_CP047298:415667-415981 [Vibrio cholerae O1 biovar El Tor]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT145833 NZ_CP062702:403134-403400 [Escherichia coli O157:H7]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5JA9
PDB 8A0X
PDB 5MJE
PDB 5JA8
PDB 5JAA

Antitoxin

Source ID Structure

References