Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 415348..415981 Replicon chromosome
Accession NZ_CP047298
Organism Vibrio cholerae O1 biovar El Tor strain C6709

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag GTF73_RS16015 Protein ID WP_000843587.1
Coordinates 415348..415680 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GTF73_RS16020 Protein ID WP_000071008.1
Coordinates 415667..415981 (+) Length 105 a.a.

Genomic Context

GTF73_RS15950GTF73_RS15955GTF73_RS15960GTF73_RS15965GTF73_RS15970GTF73_RS15975GTF73_RS15980GTF73_RS15985GTF73_RS15990GTF73_RS16000GTF73_RS16005GTF73_RS16015GTF73_RS16020GTF73_RS16025GTF73_RS16030GTF73_RS16040GTF73_RS16045GTF73_RS16050GTF73_RS16055GTF73_RS16060GTF73_RS16065GTF73_RS16070GTF73_RS15995GTF73_RS16010GTF73_RS16035
Location: 410789..410992 (204 bp)
Type: Others
Protein ID: WP_001911745.1
Location: 411273..411446 (174 bp)
Type: Others
Protein ID: WP_001882305.1
Location: 411806..412075 (270 bp)
Type: Others
Protein ID: WP_001198131.1
Location: 412386..412472 (87 bp)
Type: Others
Protein ID: WP_134820423.1
Location: 412472..412564 (93 bp)
Type: Others
Protein ID: Protein_437
Location: 412773..413159 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 413361..413603 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 413774..414151 (378 bp)
Type: Others
Protein ID: WP_000411109.1
Location: 414331..414552 (222 bp)
Type: Others
Protein ID: WP_032468461.1
Location: 414718..414831 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 414780..415007 (228 bp)
Type: Others
Protein ID: WP_001894457.1
Location: 415348..415680 (333 bp)
Type: Toxin
Protein ID: WP_000843587.1
Location: 415667..415981 (315 bp)
Type: Antitoxin
Protein ID: WP_000071008.1
Location: 416118..416552 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 416720..416875 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 418048..418320 (273 bp)
Type: Others
Protein ID: Protein_451
Location: 418491..419183 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 419183..419584 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 419554..419697 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 419772..420185 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 420399..420650 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 420640..420927 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 414528..414686 (159 bp)
Type: Others
Protein ID: WP_001894455.1
Location: 415037..415195 (159 bp)
Type: Others
Protein ID: WP_001882309.1
Location: 417000..417980 (981 bp)
Type: Others
Protein ID: WP_000019370.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTF73_RS15950410789..410992+204WP_001911745.1hypothetical protein-
GTF73_RS15955411273..411446+174WP_001882305.1DUF3709 domain-containing protein-
GTF73_RS15960411806..412075+270WP_001198131.1hypothetical protein-
GTF73_RS15965412386..412472+87WP_134820423.1DUF645 family protein-
GTF73_RS15970412472..412564+93Protein_437DUF645 family protein-
GTF73_RS15975412773..413159+387WP_000703163.1VOC family protein-
GTF73_RS15980413361..413603+243WP_000107461.1hypothetical protein-
GTF73_RS15985413774..414151+378WP_000411109.1hypothetical protein-
GTF73_RS15990414331..414552+222WP_032468461.1DUF1289 domain-containing protein-
GTF73_RS15995414528..414686-159WP_001894455.1DUF1196 family protein-
GTF73_RS16000414718..414831+114WP_001889158.1hypothetical protein-
GTF73_RS16005414780..415007+228WP_001894457.1DUF1289 domain-containing protein-
GTF73_RS16010415037..415195-159WP_001882309.1DUF1196 family protein-
GTF73_RS16015415348..415680+333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GTF73_RS16020415667..415981+315WP_000071008.1DNA-binding transcriptional regulatorAntitoxin
GTF73_RS16025416118..416552+435WP_000256036.1GNAT family N-acetyltransferase-
GTF73_RS16030416720..416875+156WP_000751734.1hypothetical protein-
GTF73_RS16035417000..417980-981WP_000019370.1IS5-like element ISVch5 family transposase-
GTF73_RS16040418048..418320+273Protein_451CatB-related O-acetyltransferase-
GTF73_RS16045418491..419183+693WP_001047169.1GNAT family N-acetyltransferase-
GTF73_RS16050419183..419584+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
GTF73_RS16055419554..419697+144WP_071908341.1DUF3265 domain-containing protein-
GTF73_RS16060419772..420185+414WP_000049417.1VOC family protein-
GTF73_RS16065420399..420650+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
GTF73_RS16070420640..420927+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306901..436162129261
insideIntegron--311981..435786123805
flankIS/Tn--417000..417980980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T145833 WP_000843587.1 NZ_CP047298:415348-415680 [Vibrio cholerae O1 biovar El Tor]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

>T145833 NZ_CP062702:403407-403934 [Escherichia coli O157:H7]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATAAATCGCTGGGCTTTATCCCTTTAGTCGGGGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT145833 WP_000071008.1 NZ_CP047298:415667-415981 [Vibrio cholerae O1 biovar El Tor]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT145833 NZ_CP062702:403134-403400 [Escherichia coli O157:H7]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB5JA9
PDB8A0X
PDB5MJE
PDB5JA8
PDB5JAA

Antitoxin

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Source
ID
Structure
No matching records found

References