45803

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 324488..325254 Replicon chromosome
Accession NZ_CP006948
Organism Vibrio cholerae O1 str. KW3

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag N900_RS15485 Protein ID WP_000982260.1
Coordinates 324488..324985 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag N900_RS15490 Protein ID WP_000246253.1
Coordinates 324982..325254 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N900_RS15440 319931..320635 + 705 WP_000087610.1 HNH endonuclease -
N900_RS15445 320793..321131 + 339 WP_000713853.1 hypothetical protein -
N900_RS15450 321285..321602 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
N900_RS15455 321621..321863 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
N900_RS15460 322107..322493 + 387 WP_001015867.1 NUDIX hydrolase -
N900_RS19420 322550..322663 + 114 WP_001900214.1 hypothetical protein -
N900_RS15465 322672..322892 + 221 Protein_279 DUF1289 domain-containing protein -
N900_RS15475 323150..323686 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
N900_RS15480 323823..324338 + 516 WP_001201509.1 lipocalin family protein -
N900_RS15485 324488..324985 - 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
N900_RS15490 324982..325254 - 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
N900_RS19910 325647..325772 + 126 WP_001900195.1 DUF645 family protein -
N900_RS19915 325788..325826 + 39 WP_106019118.1 hypothetical protein -
N900_RS15500 326022..326468 + 447 WP_000006157.1 hypothetical protein -
N900_RS15505 326531..327742 + 1212 WP_001122813.1 IS256 family transposase -
N900_RS15510 327929..328198 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
N900_RS15515 328191..328469 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
N900_RS19435 328755..329033 + 279 WP_001921601.1 DUF3709 domain-containing protein -
N900_RS19930 329285..329491 + 207 Protein_291 DUF3709 domain-containing protein -
N900_RS19935 329691..329792 + 102 WP_001921603.1 hypothetical protein -
N900_RS15525 329782..330168 + 387 WP_000703163.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304645..411088 106443
inside Integron - - 309725..410760 101035
- flank IS/Tn - - 326531..327742 1211


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T45803 WP_000982260.1 NZ_CP006948:c324985-324488 [Vibrio cholerae O1 str. KW3]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T45803 NZ_CP006948:c324985-324488 [Vibrio cholerae O1 str. KW3]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT45803 WP_000246253.1 NZ_CP006948:c325254-324982 [Vibrio cholerae O1 str. KW3]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT45803 NZ_CP006948:c325254-324982 [Vibrio cholerae O1 str. KW3]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References