Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 68308..68867 Replicon chromosome
Accession NC_016446
Organism Vibrio cholerae O1 str. 2010EL-1786

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag HJ37_RS14410 Protein ID WP_000578476.1
Coordinates 68308..68586 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag HJ37_RS14415 Protein ID WP_000381183.1
Coordinates 68583..68867 (-) Length 95 a.a.

Genomic Context

HJ37_RS14370HJ37_RS14375HJ37_RS14380HJ37_RS14385HJ37_RS19425HJ37_RS14390HJ37_RS14395HJ37_RS14400HJ37_RS14405HJ37_RS14420HJ37_RS14425HJ37_RS14430HJ37_RS14435HJ37_RS19440HJ37_RS14440HJ37_RS14445HJ37_RS19445HJ37_RS14410HJ37_RS14415
Location: 63386..63892 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 64049..64435 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 64692..64895 (204 bp)
Type: Others
Protein ID: WP_001911580.1
Location: 65090..65341 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 65314..65463 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 65610..66035 (426 bp)
Type: Others
Protein ID: WP_000415750.1
Location: 66241..66864 (624 bp)
Type: Others
Protein ID: WP_000247070.1
Location: 67077..67556 (480 bp)
Type: Others
Protein ID: WP_000009888.1
Location: 67744..68157 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 69062..69577 (516 bp)
Type: Others
Protein ID: WP_001201520.1
Location: 69642..70238 (597 bp)
Type: Others
Protein ID: WP_000255434.1
Location: 70630..70812 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 71012..71485 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 71500..71592 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 71634..72260 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 72383..73081 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 73091..73201 (111 bp)
Type: Others
Protein ID: WP_079857360.1
Location: 68308..68586 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 68583..68867 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HJ37_RS1437063386..63892+507WP_000393074.1hypothetical protein-
HJ37_RS1437564049..64435+387WP_000703163.1VOC family protein-
HJ37_RS1438064692..64895+204WP_001911580.1hypothetical protein-
HJ37_RS1438565090..65341+252WP_001890111.1TIGR03643 family protein-
HJ37_RS1942565314..65463+150WP_071908333.1DUF3265 domain-containing protein-
HJ37_RS1439065610..66035+426WP_000415750.1hypothetical protein-
HJ37_RS1439566241..66864+624WP_000247070.1DUF1349 domain-containing protein-
HJ37_RS1440067077..67556+480WP_000009888.1lecithin retinol acyltransferase family protein-
HJ37_RS1440567744..68157+414WP_000049420.1VOC family protein-
HJ37_RS1441068308..68586-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
HJ37_RS1441568583..68867-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
HJ37_RS1442069062..69577+516WP_001201520.1lipocalin family protein-
HJ37_RS1442569642..70238+597WP_000255434.1hypothetical protein-
HJ37_RS1443070630..70812+183WP_000923182.1DUF645 family protein-
HJ37_RS1443571012..71485+474WP_001161076.1GrpB family protein-
HJ37_RS1944071500..71592+93WP_014378730.1DUF3265 domain-containing protein-
HJ37_RS1444071634..72260+627WP_000365424.1LysE family translocator-
HJ37_RS1444572383..73081+699WP_001890502.1hypothetical protein-
HJ37_RS1944573091..73201+111WP_079857360.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-31115..136304105189
insideIntegroncatB9-36195..13592899733


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T25709 WP_000578476.1 NC_016446:c68586-68308 [Vibrio cholerae O1 str. 2010EL-1786]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T25709 NC_016446:c68586-68308 [Vibrio cholerae O1 str. 2010EL-1786]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT25709 WP_000381183.1 NC_016446:c68867-68583 [Vibrio cholerae O1 str. 2010EL-1786]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT25709 NC_016446:c68867-68583 [Vibrio cholerae O1 str. 2010EL-1786]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References