Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 68308..68867 | Replicon | chromosome |
| Accession | NC_016446 | ||
| Organism | Vibrio cholerae O1 str. 2010EL-1786 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | Q9K2M8 |
| Locus tag | HJ37_RS14410 | Protein ID | WP_000578476.1 |
| Coordinates | 68308..68586 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q9L991 |
| Locus tag | HJ37_RS14415 | Protein ID | WP_000381183.1 |
| Coordinates | 68583..68867 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HJ37_RS14370 | 63386..63892 | + | 507 | WP_000393074.1 | hypothetical protein | - |
| HJ37_RS14375 | 64049..64435 | + | 387 | WP_000703163.1 | VOC family protein | - |
| HJ37_RS14380 | 64692..64895 | + | 204 | WP_001911580.1 | hypothetical protein | - |
| HJ37_RS14385 | 65090..65341 | + | 252 | WP_001890111.1 | TIGR03643 family protein | - |
| HJ37_RS19425 | 65314..65463 | + | 150 | WP_071908333.1 | DUF3265 domain-containing protein | - |
| HJ37_RS14390 | 65610..66035 | + | 426 | WP_000415750.1 | hypothetical protein | - |
| HJ37_RS14395 | 66241..66864 | + | 624 | WP_000247070.1 | DUF1349 domain-containing protein | - |
| HJ37_RS14400 | 67077..67556 | + | 480 | WP_000009888.1 | lecithin retinol acyltransferase family protein | - |
| HJ37_RS14405 | 67744..68157 | + | 414 | WP_000049420.1 | VOC family protein | - |
| HJ37_RS14410 | 68308..68586 | - | 279 | WP_000578476.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| HJ37_RS14415 | 68583..68867 | - | 285 | WP_000381183.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| HJ37_RS14420 | 69062..69577 | + | 516 | WP_001201520.1 | lipocalin family protein | - |
| HJ37_RS14425 | 69642..70238 | + | 597 | WP_000255434.1 | hypothetical protein | - |
| HJ37_RS14430 | 70630..70812 | + | 183 | WP_000923182.1 | DUF645 family protein | - |
| HJ37_RS14435 | 71012..71485 | + | 474 | WP_001161076.1 | GrpB family protein | - |
| HJ37_RS19440 | 71500..71592 | + | 93 | WP_014378730.1 | DUF3265 domain-containing protein | - |
| HJ37_RS14440 | 71634..72260 | + | 627 | WP_000365424.1 | LysE family translocator | - |
| HJ37_RS14445 | 72383..73081 | + | 699 | WP_001890502.1 | hypothetical protein | - |
| HJ37_RS19445 | 73091..73201 | + | 111 | WP_079857360.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | catB9 | - | 31115..136304 | 105189 | |
| inside | Integron | catB9 | - | 36195..135928 | 99733 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10819.59 Da Isoelectric Point: 5.1651
>T25709 WP_000578476.1 NC_016446:c68586-68308 [Vibrio cholerae O1 str. 2010EL-1786]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
Download Length: 279 bp
>T25709 NC_016446:c68586-68308 [Vibrio cholerae O1 str. 2010EL-1786]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10901.25 Da Isoelectric Point: 8.0775
>AT25709 WP_000381183.1 NC_016446:c68867-68583 [Vibrio cholerae O1 str. 2010EL-1786]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA
Download Length: 285 bp
>AT25709 NC_016446:c68867-68583 [Vibrio cholerae O1 str. 2010EL-1786]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q9K2M8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A067BL33 |