Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 966548..967503 Replicon chromosome
Accession NZ_CP040173
Organism Vibrio cholerae strain VC1374

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag FDZ90_RS19280 Protein ID WP_000118351.1
Coordinates 966970..967503 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag FDZ90_RS19275 Protein ID WP_001882332.1
Coordinates 966548..966973 (+) Length 142 a.a.

Genomic Context

FDZ90_RS19230FDZ90_RS19235FDZ90_RS19240FDZ90_RS19245FDZ90_RS19260FDZ90_RS19265FDZ90_RS19270FDZ90_RS19275FDZ90_RS19280FDZ90_RS19285FDZ90_RS19290FDZ90_RS19295FDZ90_RS19300FDZ90_RS19305FDZ90_RS19310FDZ90_RS19315FDZ90_RS19320FDZ90_RS19250FDZ90_RS19255
Location: 962078..962329 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 962319..962606 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 962734..963189 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 963511..963663 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 964862..965530 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 965682..965969 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 966110..966481 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 966548..966973 (426 bp)
Type: Antitoxin
Protein ID: WP_001882332.1
Location: 966970..967503 (534 bp)
Type: Toxin
Protein ID: WP_000118351.1
Location: 967705..967962 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 967950..968252 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 968486..969403 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 969560..969949 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 970085..970294 (210 bp)
Type: Others
Protein ID: Protein_914
Location: 970413..970850 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 970913..971131 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 971306..972178 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 963865..964362 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 964359..964631 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FDZ90_RS19230962078..962329+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
FDZ90_RS19235962319..962606+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
FDZ90_RS19240962734..963189+456WP_001245327.1GNAT family N-acetyltransferase-
FDZ90_RS19245963511..963663+153WP_001884520.1DUF645 family protein-
FDZ90_RS19250963865..964362-498WP_000982260.1GNAT family N-acetyltransferase-
FDZ90_RS19255964359..964631-273WP_000246253.1DUF1778 domain-containing protein-
FDZ90_RS19260964862..965530+669WP_000043871.1hypothetical protein-
FDZ90_RS19265965682..965969+288WP_000426470.1hypothetical protein-
FDZ90_RS19270966110..966481+372WP_001164080.1nucleotide pyrophosphohydrolase-
FDZ90_RS19275966548..966973+426WP_001882332.1DUF1778 domain-containing proteinAntitoxin
FDZ90_RS19280966970..967503+534WP_000118351.1GNAT family N-acetyltransferaseToxin
FDZ90_RS19285967705..967962+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
FDZ90_RS19290967950..968252+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
FDZ90_RS19295968486..969403+918WP_000186333.1alpha/beta hydrolase-
FDZ90_RS19300969560..969949+390WP_001081302.1hypothetical protein-
FDZ90_RS19305970085..970294+210Protein_914GNAT family N-acetyltransferase-
FDZ90_RS19310970413..970850+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
FDZ90_RS19315970913..971131+219WP_071908318.1GNAT family N-acetyltransferase-
FDZ90_RS19320971306..972178+873WP_000254716.1DUF3800 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-882589..97784095251
insideIntegroncatB9-887669..97746489795
flankIS/Tn--970413..970850437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(57-133)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T125048 WP_000118351.1 NZ_CP040173:966970-967503 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T125048 NZ_CP040173:966970-967503 [Vibrio cholerae]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGCCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATACGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15714.41 Da        Isoelectric Point: 7.6659

>AT125048 WP_001882332.1 NZ_CP040173:966548-966973 [Vibrio cholerae]
MLCLSLVVMRCQPLRRALYSPSPRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLK
SLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK

Download         Length: 426 bp

>AT125048 NZ_CP040173:966548-966973 [Vibrio cholerae]
TTGTTGTGTTTGAGTTTAGTGGTCATGCGTTGTCAGCCCCTTAGACGGGCGTTATATTCTCCCTCGCCCCGTAAACTTTC
CGTACGAATTGAATGTGCTTTAAGTTTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTACGCAGGAGGGGTTATGG
CAACGGCACGTTTAGATATCCGCCTTGATGAAGAGATCAAGGCAAAAGCTGAAAAGGCATCGGCTTTACTTGGTTTAAAA
AGTCTCACTGAATATGTGGTGAGACTTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGGTTAA
AGACAGTGTTTTTGACGAGTTTATGGCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAAT
TTACAGAGAAGAGCGGTATCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM94

Antitoxin

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Source
ID
Structure
No matching records found

References