Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc(toxin)
Location 852221..852792 Replicon chromosome
Accession NZ_CP090400
Organism Vibrio cholerae strain PanChol

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag LZM82_RS17390 Protein ID WP_000351248.1
Coordinates 852221..852622 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q8GNG3
Locus tag LZM82_RS17395 Protein ID WP_001080654.1
Coordinates 852622..852792 (-) Length 57 a.a.

Genomic Context

LZM82_RS17335LZM82_RS17340LZM82_RS17410LZM82_RS17320LZM82_RS17325LZM82_RS17330LZM82_RS17345LZM82_RS17350LZM82_RS17360LZM82_RS17365LZM82_RS17370LZM82_RS17375LZM82_RS17380LZM82_RS17385LZM82_RS17390LZM82_RS17395LZM82_RS17400LZM82_RS17405LZM82_RS17415LZM82_RS17420LZM82_RS17425LZM82_RS17430LZM82_RS17435LZM82_RS17440LZM82_RS17445LZM82_RS17450
Location: 848853..849125 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 849122..849619 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 853825..854805 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 847515..847802 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 847954..848622 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 848639..848701 (63 bp)
Type: Others
Protein ID: Protein_733
Location: 849636..849704 (69 bp)
Type: Others
Protein ID: Protein_736
Location: 849821..849925 (105 bp)
Type: Others
Protein ID: WP_228840819.1
Location: 850116..850238 (123 bp)
Type: Others
Protein ID: Protein_738
Location: 850295..850750 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 850878..851165 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 851155..851406 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 851620..852033 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 852108..852218 (111 bp)
Type: Others
Protein ID: WP_082798255.1
Location: 852221..852622 (402 bp)
Type: Toxin
Protein ID: WP_000351248.1
Location: 852622..852792 (171 bp)
Type: Antitoxin
Protein ID: WP_001080654.1
Location: 852916..853314 (399 bp)
Type: Others
Protein ID: Protein_746
Location: 853451..853757 (307 bp)
Type: Others
Protein ID: Protein_747
Location: 854930..855085 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 855253..855687 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 855824..856138 (315 bp)
Type: Others
Protein ID: WP_000071008.1
Location: 856125..856457 (333 bp)
Type: Others
Protein ID: WP_000843587.1
Location: 856798..857025 (228 bp)
Type: Others
Protein ID: WP_073426587.1
Location: 856974..857087 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 857253..857474 (222 bp)
Type: Others
Protein ID: WP_032468461.1
Location: 857483..857597 (115 bp)
Type: Others
Protein ID: Protein_756
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LZM82_RS17320 (LZM82_17320)847515..847802-288WP_000426470.1hypothetical protein-
LZM82_RS17325 (LZM82_17325)847954..848622-669WP_000043871.1hypothetical protein-
LZM82_RS17330 (LZM82_17330)848639..848701-63Protein_733acetyltransferase-
LZM82_RS17335 (LZM82_17335)848853..849125+273WP_000246253.1DUF1778 domain-containing protein-
LZM82_RS17340 (LZM82_17340)849122..849619+498WP_000982260.1GNAT family N-acetyltransferase-
LZM82_RS17345 (LZM82_17345)849636..849704-69Protein_736acetyltransferase-
LZM82_RS17350 (LZM82_17350)849821..849925-105WP_228840819.1DUF645 family protein-
LZM82_RS17360 (LZM82_17360)850116..850238-123Protein_738acetyltransferase-
LZM82_RS17365 (LZM82_17365)850295..850750-456WP_001245327.1GNAT family N-acetyltransferase-
LZM82_RS17370 (LZM82_17370)850878..851165-288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
LZM82_RS17375 (LZM82_17375)851155..851406-252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
LZM82_RS17380 (LZM82_17380)851620..852033-414WP_000049417.1VOC family protein-
LZM82_RS17385 (LZM82_17385)852108..852218-111WP_082798255.1DUF3265 domain-containing protein-
LZM82_RS17390 (LZM82_17390)852221..852622-402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxinToxin
LZM82_RS17395 (LZM82_17395)852622..852792-171WP_001080654.1hypothetical proteinAntitoxin
LZM82_RS17400 (LZM82_17400)852916..853314-399Protein_746GNAT family N-acetyltransferase-
LZM82_RS17405 (LZM82_17405)853451..853757-307Protein_747CatB-related O-acetyltransferase-
LZM82_RS17410 (LZM82_17410)853825..854805+981WP_000019370.1IS5-like element ISVch5 family transposase-
LZM82_RS17415 (LZM82_17415)854930..855085-156WP_000751734.1hypothetical protein-
LZM82_RS17420 (LZM82_17420)855253..855687-435WP_000256036.1GNAT family N-acetyltransferase-
LZM82_RS17425 (LZM82_17425)855824..856138-315WP_000071008.1DNA-binding transcriptional regulator-
LZM82_RS17430 (LZM82_17430)856125..856457-333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxin-
LZM82_RS17435 (LZM82_17435)856798..857025-228WP_073426587.1DUF1289 domain-containing protein-
LZM82_RS17440 (LZM82_17440)856974..857087-114WP_001889158.1hypothetical protein-
LZM82_RS17445 (LZM82_17445)857253..857474-222WP_032468461.1DUF1289 domain-containing protein-
LZM82_RS17450 (LZM82_17450)857483..857597-115Protein_756acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-835643..943910108267
insideIntegron--836019..937068101049
flankIS/Tn--853825..854805980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T230641 WP_000351248.1 NZ_CP090400:c852622-852221 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T230641 NZ_CP125221:36548-36853 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCAGTTTAAGGTTTACACCTGTAAAAGGGAGAGTCGCTACCGGCTGTTTGTGGACGTGCAGAGCGACATCATTGACAC
CCCCGGACGGCGGATGGCTGTCCCGCTGGTCAGCGCCCGTCTGCTGTCGGAAAAGGTTCCCCGCGATCTTTACCCGGTGA
TGCATATCGGGGATGAGCCTTACCGCCTGCTGACCACGGATATGACCAGTGTGCCGGCCACCGTCATCGGGGAAGAGGTG
GCCGATCTCAGCCTCCGGGAGAACGATATCAAAAACGCCATTAACCTGATGTTCCGGGGGATCTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6287.35 Da        Isoelectric Point: 10.7274

>AT230641 WP_001080654.1 NZ_CP090400:c852792-852622 [Vibrio cholerae]
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 171 bp

>AT230641 NZ_CP125221:36328-36546 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAAGCAGCGAATTACAGTGACAGTGGACAGCGACAGCTATCAGCTGCTCAAGGCATACGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGCCGTCTGCGAGCCGAACGCTGGCAGGAAGAAAATCGGGAAGGTATGGCTG
AGGTGGCCAGCTTTATAGAGGCTAACGGATCGTTTGCTGACGACAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0PN34

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1T4SJJ1

References