230641

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc(toxin)
Location 852221..852792 Replicon chromosome
Accession NZ_CP090400
Organism Vibrio cholerae strain PanChol

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag LZM82_RS17390 Protein ID WP_000351248.1
Coordinates 852221..852622 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q8GNG3
Locus tag LZM82_RS17395 Protein ID WP_001080654.1
Coordinates 852622..852792 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZM82_RS17320 (LZM82_17320) 847515..847802 - 288 WP_000426470.1 hypothetical protein -
LZM82_RS17325 (LZM82_17325) 847954..848622 - 669 WP_000043871.1 hypothetical protein -
LZM82_RS17330 (LZM82_17330) 848639..848701 - 63 Protein_733 acetyltransferase -
LZM82_RS17335 (LZM82_17335) 848853..849125 + 273 WP_000246253.1 DUF1778 domain-containing protein -
LZM82_RS17340 (LZM82_17340) 849122..849619 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
LZM82_RS17345 (LZM82_17345) 849636..849704 - 69 Protein_736 acetyltransferase -
LZM82_RS17350 (LZM82_17350) 849821..849925 - 105 WP_228840819.1 DUF645 family protein -
LZM82_RS17360 (LZM82_17360) 850116..850238 - 123 Protein_738 acetyltransferase -
LZM82_RS17365 (LZM82_17365) 850295..850750 - 456 WP_001245327.1 GNAT family N-acetyltransferase -
LZM82_RS17370 (LZM82_17370) 850878..851165 - 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
LZM82_RS17375 (LZM82_17375) 851155..851406 - 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
LZM82_RS17380 (LZM82_17380) 851620..852033 - 414 WP_000049417.1 VOC family protein -
LZM82_RS17385 (LZM82_17385) 852108..852218 - 111 WP_082798255.1 DUF3265 domain-containing protein -
LZM82_RS17390 (LZM82_17390) 852221..852622 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
LZM82_RS17395 (LZM82_17395) 852622..852792 - 171 WP_001080654.1 hypothetical protein Antitoxin
LZM82_RS17400 (LZM82_17400) 852916..853314 - 399 Protein_746 GNAT family N-acetyltransferase -
LZM82_RS17405 (LZM82_17405) 853451..853757 - 307 Protein_747 CatB-related O-acetyltransferase -
LZM82_RS17410 (LZM82_17410) 853825..854805 + 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
LZM82_RS17415 (LZM82_17415) 854930..855085 - 156 WP_000751734.1 hypothetical protein -
LZM82_RS17420 (LZM82_17420) 855253..855687 - 435 WP_000256036.1 GNAT family N-acetyltransferase -
LZM82_RS17425 (LZM82_17425) 855824..856138 - 315 WP_000071008.1 DNA-binding transcriptional regulator -
LZM82_RS17430 (LZM82_17430) 856125..856457 - 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin -
LZM82_RS17435 (LZM82_17435) 856798..857025 - 228 WP_073426587.1 DUF1289 domain-containing protein -
LZM82_RS17440 (LZM82_17440) 856974..857087 - 114 WP_001889158.1 hypothetical protein -
LZM82_RS17445 (LZM82_17445) 857253..857474 - 222 WP_032468461.1 DUF1289 domain-containing protein -
LZM82_RS17450 (LZM82_17450) 857483..857597 - 115 Protein_756 acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 835643..943910 108267
inside Integron - - 836019..937068 101049
flank IS/Tn - - 853825..854805 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T230641 WP_000351248.1 NZ_CP090400:c852622-852221 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T230641 NZ_CP125221:36548-36853 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCAGTTTAAGGTTTACACCTGTAAAAGGGAGAGTCGCTACCGGCTGTTTGTGGACGTGCAGAGCGACATCATTGACAC
CCCCGGACGGCGGATGGCTGTCCCGCTGGTCAGCGCCCGTCTGCTGTCGGAAAAGGTTCCCCGCGATCTTTACCCGGTGA
TGCATATCGGGGATGAGCCTTACCGCCTGCTGACCACGGATATGACCAGTGTGCCGGCCACCGTCATCGGGGAAGAGGTG
GCCGATCTCAGCCTCCGGGAGAACGATATCAAAAACGCCATTAACCTGATGTTCCGGGGGATCTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6287.35 Da        Isoelectric Point: 10.7274

>AT230641 WP_001080654.1 NZ_CP090400:c852792-852622 [Vibrio cholerae]
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 171 bp

>AT230641 NZ_CP125221:36328-36546 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAAGCAGCGAATTACAGTGACAGTGGACAGCGACAGCTATCAGCTGCTCAAGGCATACGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGCCGTCTGCGAGCCGAACGCTGGCAGGAAGAAAATCGGGAAGGTATGGCTG
AGGTGGCCAGCTTTATAGAGGCTAACGGATCGTTTGCTGACGACAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0PN34

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SJJ1

References