Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 332133..332631 Replicon chromosome
Accession NZ_CP024163
Organism Vibrio cholerae strain E7946

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag CSW01_RS15755 Protein ID WP_000589156.1
Coordinates 332133..332399 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag CSW01_RS15760 Protein ID WP_000643598.1
Coordinates 332386..332631 (+) Length 82 a.a.

Genomic Context

CSW01_RS19805CSW01_RS15690CSW01_RS15695CSW01_RS15700CSW01_RS15705CSW01_RS15710CSW01_RS15715CSW01_RS19945CSW01_RS19950CSW01_RS15740CSW01_RS15745CSW01_RS15755CSW01_RS15760CSW01_RS15765CSW01_RS19955CSW01_RS15780CSW01_RS15785CSW01_RS15795CSW01_RS15800CSW01_RS15805CSW01_RS15810
Location: 327554..327760 (207 bp)
Type: Others
Protein ID: Protein_289
Location: 327960..328061 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 328051..328437 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 328632..328883 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 328856..329005 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 329097..329339 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 329591..329869 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 330244..330387 (144 bp)
Type: Others
Protein ID: Protein_296
Location: 330441..330479 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 330691..331158 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 331286..331948 (663 bp)
Type: Others
Protein ID: WP_000960654.1
Location: 332133..332399 (267 bp)
Type: Toxin
Protein ID: WP_000589156.1
Location: 332386..332631 (246 bp)
Type: Antitoxin
Protein ID: WP_000643598.1
Location: 332727..333521 (795 bp)
Type: Others
Protein ID: WP_001911581.1
Location: 333624..333752 (129 bp)
Type: Others
Protein ID: WP_071908338.1
Location: 333813..333995 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 334211..335215 (1005 bp)
Type: Others
Protein ID: WP_000964920.1
Location: 335368..335727 (360 bp)
Type: Others
Protein ID: WP_001071541.1
Location: 336000..336233 (234 bp)
Type: Others
Protein ID: WP_001890112.1
Location: 336501..337007 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 337164..337550 (387 bp)
Type: Others
Protein ID: WP_000703163.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CSW01_RS19805327554..327760+207Protein_289DUF3709 domain-containing protein-
CSW01_RS15690327960..328061+102WP_001921603.1hypothetical protein-
CSW01_RS15695328051..328437+387WP_000703163.1VOC family protein-
CSW01_RS15700328632..328883+252WP_001890111.1TIGR03643 family protein-
CSW01_RS15705328856..329005+150WP_071908333.1DUF3265 domain-containing protein-
CSW01_RS15710329097..329339+243WP_000107461.1hypothetical protein-
CSW01_RS15715329591..329869+279WP_000280324.1DUF3709 domain-containing protein-
CSW01_RS19945330244..330387+144Protein_296DUF645 family protein-
CSW01_RS19950330441..330479+39WP_082798268.1hypothetical protein-
CSW01_RS15740330691..331158+468WP_001289288.1OsmC family protein-
CSW01_RS15745331286..331948+663WP_000960654.1hypothetical protein-
CSW01_RS15755332133..332399+267WP_000589156.1BrnT family toxinToxin
CSW01_RS15760332386..332631+246WP_000643598.1hypothetical proteinAntitoxin
CSW01_RS15765332727..333521+795WP_001911581.1hypothetical protein-
CSW01_RS19955333624..333752+129WP_071908338.1general secretion pathway protein GspI-
CSW01_RS15780333813..333995+183WP_000923182.1DUF645 family protein-
CSW01_RS15785334211..335215+1005WP_000964920.1LD-carboxypeptidase-
CSW01_RS15795335368..335727+360WP_001071541.1VOC family protein-
CSW01_RS15800336000..336233+234WP_001890112.1DUF3709 domain-containing protein-
CSW01_RS15805336501..337007+507WP_000393074.1hypothetical protein-
CSW01_RS15810337164..337550+387WP_000703163.1VOC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304226..433944129718
insideIntegron--309306..433568124262


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T87019 WP_000589156.1 NZ_CP024163:332133-332399 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T87019 NZ_CP024163:332133-332399 [Vibrio cholerae]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
ATTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT87019 WP_000643598.1 NZ_CP024163:332386-332631 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT87019 NZ_CP024163:332386-332631 [Vibrio cholerae]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A271VMP7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A271VME2

References