145885

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 329004..329544 Replicon chromosome
Accession NZ_CP047304
Organism Vibrio cholerae O1 biovar El Tor strain E7946

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag GTF74_RS15225 Protein ID WP_000277238.1
Coordinates 329004..329273 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag GTF74_RS15230 Protein ID WP_001258569.1
Coordinates 329266..329544 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF74_RS15165 324008..324250 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GTF74_RS15170 324494..324880 + 387 WP_001015867.1 NUDIX hydrolase -
GTF74_RS15175 324937..325050 + 114 WP_001900214.1 hypothetical protein -
GTF74_RS15180 324999..325280 + 282 WP_001894429.1 DUF1289 domain-containing protein -
GTF74_RS15185 325256..325414 - 159 WP_001886450.1 DUF1196 family protein -
GTF74_RS15190 325538..326074 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
GTF74_RS15195 326211..326726 + 516 WP_001201509.1 lipocalin family protein -
GTF74_RS15200 326876..327373 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
GTF74_RS15205 327370..327642 - 273 WP_000246253.1 DUF1778 domain-containing protein -
GTF74_RS15210 328035..328160 + 126 WP_001900195.1 DUF645 family protein -
GTF74_RS15215 328176..328214 + 39 WP_106019118.1 hypothetical protein -
GTF74_RS15220 328410..328856 + 447 WP_000006157.1 hypothetical protein -
GTF74_RS15225 329004..329273 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
GTF74_RS15230 329266..329544 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GTF74_RS15235 329830..330108 + 279 WP_001921601.1 DUF3709 domain-containing protein -
GTF74_RS15240 330360..330566 + 207 Protein_294 DUF3709 domain-containing protein -
GTF74_RS15245 330766..330867 + 102 WP_001921603.1 hypothetical protein -
GTF74_RS15250 330857..331243 + 387 WP_000703163.1 VOC family protein -
GTF74_RS15255 331438..331689 + 252 WP_001890111.1 TIGR03643 family protein -
GTF74_RS15260 331662..331811 + 150 WP_071908333.1 DUF3265 domain-containing protein -
GTF74_RS15265 331903..332145 + 243 WP_000107461.1 hypothetical protein -
GTF74_RS15270 332397..332675 + 279 WP_000280324.1 DUF3709 domain-containing protein -
GTF74_RS15275 333050..333193 + 144 Protein_301 DUF645 family protein -
GTF74_RS15280 333247..333285 + 39 WP_082798268.1 hypothetical protein -
GTF74_RS15285 333497..333964 + 468 WP_001289288.1 OsmC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 307032..436751 129719
inside Integron - - 312112..436375 124263


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T145885 WP_000277238.1 NZ_CP047304:c329273-329004 [Vibrio cholerae O1 biovar El Tor]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T145885 NZ_CP062705:4829141-4829482 [Escherichia coli O157:H7]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT145885 WP_001258569.1 NZ_CP047304:c329544-329266 [Vibrio cholerae O1 biovar El Tor]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT145885 NZ_CP062705:c4829146-4829070 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References