Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 329004..329544 Replicon chromosome
Accession NZ_CP047304
Organism Vibrio cholerae O1 biovar El Tor strain E7946

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag GTF74_RS15225 Protein ID WP_000277238.1
Coordinates 329004..329273 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag GTF74_RS15230 Protein ID WP_001258569.1
Coordinates 329266..329544 (-) Length 93 a.a.

Genomic Context

GTF74_RS15170GTF74_RS15175GTF74_RS15180GTF74_RS15190GTF74_RS15195GTF74_RS15210GTF74_RS15215GTF74_RS15220GTF74_RS15235GTF74_RS15240GTF74_RS15245GTF74_RS15250GTF74_RS15255GTF74_RS15260GTF74_RS15265GTF74_RS15270GTF74_RS15275GTF74_RS15280GTF74_RS15285GTF74_RS15165GTF74_RS15185GTF74_RS15200GTF74_RS15205GTF74_RS15225GTF74_RS15230
Location: 324494..324880 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 324937..325050 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 324999..325280 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 325538..326074 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 326211..326726 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 328035..328160 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 328176..328214 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 328410..328856 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 329830..330108 (279 bp)
Type: Others
Protein ID: WP_001921601.1
Location: 330360..330566 (207 bp)
Type: Others
Protein ID: Protein_294
Location: 330766..330867 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 330857..331243 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 331438..331689 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 331662..331811 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 331903..332145 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 332397..332675 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 333050..333193 (144 bp)
Type: Others
Protein ID: Protein_301
Location: 333247..333285 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 333497..333964 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 324008..324250 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 325256..325414 (159 bp)
Type: Others
Protein ID: WP_001886450.1
Location: 326876..327373 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 327370..327642 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 329004..329273 (270 bp)
Type: Toxin
Protein ID: WP_000277238.1
Location: 329266..329544 (279 bp)
Type: Antitoxin
Protein ID: WP_001258569.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTF74_RS15165324008..324250-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
GTF74_RS15170324494..324880+387WP_001015867.1NUDIX hydrolase-
GTF74_RS15175324937..325050+114WP_001900214.1hypothetical protein-
GTF74_RS15180324999..325280+282WP_001894429.1DUF1289 domain-containing protein-
GTF74_RS15185325256..325414-159WP_001886450.1DUF1196 family protein-
GTF74_RS15190325538..326074+537WP_000469482.1GNAT family N-acetyltransferase-
GTF74_RS15195326211..326726+516WP_001201509.1lipocalin family protein-
GTF74_RS15200326876..327373-498WP_000982260.1GNAT family N-acetyltransferase-
GTF74_RS15205327370..327642-273WP_000246253.1DUF1778 domain-containing protein-
GTF74_RS15210328035..328160+126WP_001900195.1DUF645 family protein-
GTF74_RS15215328176..328214+39WP_106019118.1hypothetical protein-
GTF74_RS15220328410..328856+447WP_000006157.1hypothetical protein-
GTF74_RS15225329004..329273-270WP_000277238.1type II toxin-antitoxin system YafQ family toxinToxin
GTF74_RS15230329266..329544-279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
GTF74_RS15235329830..330108+279WP_001921601.1DUF3709 domain-containing protein-
GTF74_RS15240330360..330566+207Protein_294DUF3709 domain-containing protein-
GTF74_RS15245330766..330867+102WP_001921603.1hypothetical protein-
GTF74_RS15250330857..331243+387WP_000703163.1VOC family protein-
GTF74_RS15255331438..331689+252WP_001890111.1TIGR03643 family protein-
GTF74_RS15260331662..331811+150WP_071908333.1DUF3265 domain-containing protein-
GTF74_RS15265331903..332145+243WP_000107461.1hypothetical protein-
GTF74_RS15270332397..332675+279WP_000280324.1DUF3709 domain-containing protein-
GTF74_RS15275333050..333193+144Protein_301DUF645 family protein-
GTF74_RS15280333247..333285+39WP_082798268.1hypothetical protein-
GTF74_RS15285333497..333964+468WP_001289288.1OsmC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-307032..436751129719
insideIntegron--312112..436375124263


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T145885 WP_000277238.1 NZ_CP047304:c329273-329004 [Vibrio cholerae O1 biovar El Tor]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T145885 NZ_CP062705:4829141-4829482 [Escherichia coli O157:H7]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT145885 WP_001258569.1 NZ_CP047304:c329544-329266 [Vibrio cholerae O1 biovar El Tor]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT145885 NZ_CP062705:c4829146-4829070 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A151JGK8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A151KTP9

References