Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 324544..325310 Replicon chromosome
Accession NZ_CP009041
Organism Vibrio cholerae O1 biovar El Tor strain FJ147

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag IR04_RS01460 Protein ID WP_000982260.1
Coordinates 324544..325041 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag IR04_RS01465 Protein ID WP_000246253.1
Coordinates 325038..325310 (-) Length 91 a.a.

Genomic Context

IR04_RS01415IR04_RS01420IR04_RS01435IR04_RS19160IR04_RS01440IR04_RS01450IR04_RS01455IR04_RS19885IR04_RS19890IR04_RS01475IR04_RS19175IR04_RS19905IR04_RS19910IR04_RS01495IR04_RS01500IR04_RS19185IR04_RS01505IR04_RS01425IR04_RS01430IR04_RS01460IR04_RS01465IR04_RS01480IR04_RS01485
Location: 319986..320690 (705 bp)
Type: Others
Protein ID: WP_000087610.1
Location: 320848..321186 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 322162..322548 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 322605..322718 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 322667..322948 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 323206..323742 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 323879..324394 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 325703..325828 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 325844..325882 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 326078..326524 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 327498..327776 (279 bp)
Type: Others
Protein ID: WP_001921601.1
Location: 328028..328234 (207 bp)
Type: Others
Protein ID: Protein_290
Location: 328434..328535 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 328525..328911 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 329106..329357 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 329330..329479 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 329571..329813 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 321340..321657 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 321676..321918 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 324544..325041 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 325038..325310 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
Location: 326672..326941 (270 bp)
Type: Others
Protein ID: WP_000277238.1
Location: 326934..327212 (279 bp)
Type: Others
Protein ID: WP_001258569.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
IR04_RS01415319986..320690+705WP_000087610.1HNH endonuclease-
IR04_RS01420320848..321186+339WP_000713853.1hypothetical protein-
IR04_RS01425321340..321657-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
IR04_RS01430321676..321918-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
IR04_RS01435322162..322548+387WP_001015867.1NUDIX hydrolase-
IR04_RS19160322605..322718+114WP_001900214.1hypothetical protein-
IR04_RS01440322667..322948+282WP_001894429.1DUF1289 domain-containing protein-
IR04_RS01450323206..323742+537WP_000469482.1GNAT family N-acetyltransferase-
IR04_RS01455323879..324394+516WP_001201509.1lipocalin family protein-
IR04_RS01460324544..325041-498WP_000982260.1GNAT family N-acetyltransferaseToxin
IR04_RS01465325038..325310-273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
IR04_RS19885325703..325828+126WP_001900195.1DUF645 family protein-
IR04_RS19890325844..325882+39WP_106019118.1hypothetical protein-
IR04_RS01475326078..326524+447WP_000006157.1hypothetical protein-
IR04_RS01480326672..326941-270WP_000277238.1type II toxin-antitoxin system YafQ family toxin-
IR04_RS01485326934..327212-279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
IR04_RS19175327498..327776+279WP_001921601.1DUF3709 domain-containing protein-
IR04_RS19905328028..328234+207Protein_290DUF3709 domain-containing protein-
IR04_RS19910328434..328535+102WP_001921603.1hypothetical protein-
IR04_RS01495328525..328911+387WP_000703163.1VOC family protein-
IR04_RS01500329106..329357+252WP_001890111.1TIGR03643 family protein-
IR04_RS19185329330..329479+150WP_071908333.1DUF3265 domain-containing protein-
IR04_RS01505329571..329813+243WP_000107461.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304700..409892105192
insideIntegron--309780..40951699736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T48146 WP_000982260.1 NZ_CP009041:c325041-324544 [Vibrio cholerae O1 biovar El Tor]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T48146 NZ_CP009041:c325041-324544 [Vibrio cholerae O1 biovar El Tor]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT48146 WP_000246253.1 NZ_CP009041:c325310-325038 [Vibrio cholerae O1 biovar El Tor]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT48146 NZ_CP009041:c325310-325038 [Vibrio cholerae O1 biovar El Tor]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References