48146

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 324544..325310 Replicon chromosome
Accession NZ_CP009041
Organism Vibrio cholerae O1 biovar El Tor strain FJ147

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag IR04_RS01460 Protein ID WP_000982260.1
Coordinates 324544..325041 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag IR04_RS01465 Protein ID WP_000246253.1
Coordinates 325038..325310 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IR04_RS01415 319986..320690 + 705 WP_000087610.1 HNH endonuclease -
IR04_RS01420 320848..321186 + 339 WP_000713853.1 hypothetical protein -
IR04_RS01425 321340..321657 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
IR04_RS01430 321676..321918 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
IR04_RS01435 322162..322548 + 387 WP_001015867.1 NUDIX hydrolase -
IR04_RS19160 322605..322718 + 114 WP_001900214.1 hypothetical protein -
IR04_RS01440 322667..322948 + 282 WP_001894429.1 DUF1289 domain-containing protein -
IR04_RS01450 323206..323742 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
IR04_RS01455 323879..324394 + 516 WP_001201509.1 lipocalin family protein -
IR04_RS01460 324544..325041 - 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
IR04_RS01465 325038..325310 - 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
IR04_RS19885 325703..325828 + 126 WP_001900195.1 DUF645 family protein -
IR04_RS19890 325844..325882 + 39 WP_106019118.1 hypothetical protein -
IR04_RS01475 326078..326524 + 447 WP_000006157.1 hypothetical protein -
IR04_RS01480 326672..326941 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
IR04_RS01485 326934..327212 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
IR04_RS19175 327498..327776 + 279 WP_001921601.1 DUF3709 domain-containing protein -
IR04_RS19905 328028..328234 + 207 Protein_290 DUF3709 domain-containing protein -
IR04_RS19910 328434..328535 + 102 WP_001921603.1 hypothetical protein -
IR04_RS01495 328525..328911 + 387 WP_000703163.1 VOC family protein -
IR04_RS01500 329106..329357 + 252 WP_001890111.1 TIGR03643 family protein -
IR04_RS19185 329330..329479 + 150 WP_071908333.1 DUF3265 domain-containing protein -
IR04_RS01505 329571..329813 + 243 WP_000107461.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304700..409892 105192
inside Integron - - 309780..409516 99736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T48146 WP_000982260.1 NZ_CP009041:c325041-324544 [Vibrio cholerae O1 biovar El Tor]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T48146 NZ_CP009041:c325041-324544 [Vibrio cholerae O1 biovar El Tor]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT48146 WP_000246253.1 NZ_CP009041:c325310-325038 [Vibrio cholerae O1 biovar El Tor]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT48146 NZ_CP009041:c325310-325038 [Vibrio cholerae O1 biovar El Tor]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References