Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-YafN |
Location | 447788..448316 | Replicon | chromosome |
Accession | NZ_CP013306 | ||
Organism | Vibrio cholerae strain CRC1106 |
Toxin (Protein)
Gene name | relE | Uniprot ID | A0A0X1KZS6 |
Locus tag | ASZ81_RS16980 | Protein ID | WP_000221354.1 |
Coordinates | 448029..448316 (+) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | A0A0X1KZS8 |
Locus tag | ASZ81_RS16975 | Protein ID | WP_001250179.1 |
Coordinates | 447788..448039 (+) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
ASZ81_RS16925 | 443056..443370 | + | 315 | WP_000071008.1 | DNA-binding transcriptional regulator | - |
ASZ81_RS16930 | 443507..443941 | + | 435 | WP_000256036.1 | GNAT family N-acetyltransferase | - |
ASZ81_RS20760 | 444109..444264 | + | 156 | WP_000751734.1 | hypothetical protein | - |
ASZ81_RS16945 | 444389..445369 | - | 981 | WP_000019370.1 | IS5-like element ISVch5 family transposase | - |
ASZ81_RS16950 | 445437..445743 | + | 307 | Protein_494 | CatB-related O-acetyltransferase | - |
ASZ81_RS16955 | 445880..446572 | + | 693 | WP_001047169.1 | GNAT family N-acetyltransferase | - |
ASZ81_RS16960 | 446572..446973 | + | 402 | WP_000351248.1 | type II toxin-antitoxin system death-on-curing family toxin | - |
ASZ81_RS20675 | 446943..447086 | + | 144 | WP_071908341.1 | DUF3265 domain-containing protein | - |
ASZ81_RS16970 | 447161..447574 | + | 414 | WP_000049417.1 | VOC family protein | - |
ASZ81_RS16975 | 447788..448039 | + | 252 | WP_001250179.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
ASZ81_RS16980 | 448029..448316 | + | 288 | WP_000221354.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
ASZ81_RS16985 | 448444..448899 | + | 456 | WP_001245327.1 | GNAT family N-acetyltransferase | - |
ASZ81_RS16995 | 449221..449373 | + | 153 | WP_001884520.1 | DUF645 family protein | - |
ASZ81_RS17000 | 449575..450072 | - | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
ASZ81_RS17005 | 450069..450341 | - | 273 | WP_000246253.1 | DUF1778 domain-containing protein | - |
ASZ81_RS17010 | 450572..451240 | + | 669 | WP_000043871.1 | hypothetical protein | - |
ASZ81_RS17015 | 451392..451679 | + | 288 | WP_000426470.1 | hypothetical protein | - |
ASZ81_RS17020 | 451820..452191 | + | 372 | WP_001164080.1 | nucleotide pyrophosphohydrolase | - |
ASZ81_RS17025 | 452258..452683 | + | 426 | WP_001882332.1 | DUF1778 domain-containing protein | - |
ASZ81_RS17030 | 452680..453213 | + | 534 | WP_000118351.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | catB9 | - | 304741..463550 | 158809 | |
inside | Integron | - | - | 309821..463174 | 153353 | ||
flank | IS/Tn | - | - | 444389..445369 | 980 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10991.96 Da Isoelectric Point: 10.4934
>T58274 WP_000221354.1 NZ_CP013306:448029-448316 [Vibrio cholerae]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG
Download Length: 288 bp
>T58274 NZ_CP013306:448029-448316 [Vibrio cholerae]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9136.29 Da Isoelectric Point: 4.0197
>AT58274 WP_001250179.1 NZ_CP013306:447788-448039 [Vibrio cholerae]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL
Download Length: 252 bp
>AT58274 NZ_CP013306:447788-448039 [Vibrio cholerae]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0X1KZS6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0X1KZS8 |