58375

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 115088..115635 Replicon chromosome
Accession NZ_CP013316
Organism Vibrio cholerae strain M2140

Toxin (Protein)


Gene name relE Uniprot ID C3LV30
Locus tag ASZ83_RS14560 Protein ID WP_000229318.1
Coordinates 115333..115635 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag ASZ83_RS14555 Protein ID WP_000861987.1
Coordinates 115088..115345 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ83_RS14500 110231..110344 + 114 WP_001900214.1 hypothetical protein -
ASZ83_RS14505 110293..110574 + 282 WP_001894429.1 DUF1289 domain-containing protein -
ASZ83_RS14515 110832..111368 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
ASZ83_RS14520 111505..112020 + 516 WP_001201509.1 lipocalin family protein -
ASZ83_RS14525 112170..112667 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
ASZ83_RS14530 112664..112936 - 273 WP_000246253.1 DUF1778 domain-containing protein -
ASZ83_RS19990 113329..113454 + 126 WP_001900195.1 DUF645 family protein -
ASZ83_RS19995 113470..113508 + 39 WP_106019118.1 hypothetical protein -
ASZ83_RS14540 113704..114150 + 447 WP_000006157.1 hypothetical protein -
ASZ83_RS14545 114298..114567 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
ASZ83_RS14550 114560..114838 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
ASZ83_RS14555 115088..115345 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ASZ83_RS14560 115333..115635 + 303 WP_000229318.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ASZ83_RS14565 115924..116148 + 225 WP_001894423.1 DUF3709 domain-containing protein -
ASZ83_RS14570 116592..116711 + 120 WP_071919600.1 DUF645 family protein -
ASZ83_RS20010 116715..116768 + 54 Protein_123 DUF645 family protein -
ASZ83_RS14585 117370..118374 + 1005 WP_000964931.1 LD-carboxypeptidase -
ASZ83_RS14595 119149..119329 + 181 Protein_125 DUF645 family protein -
ASZ83_RS14600 119596..119883 + 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
ASZ83_RS14605 119894..120211 + 318 WP_001232701.1 HigA family addiction module antidote protein -
ASZ83_RS20435 120208..120318 + 111 WP_134814058.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 87981..224211 136230
inside Integron - - 93061..221594 128533


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11751.69 Da        Isoelectric Point: 5.1972

>T58375 WP_000229318.1 NZ_CP013316:115333-115635 [Vibrio cholerae]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRIPPELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T58375 NZ_CP013316:115333-115635 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCCGGCTCTATCCGACCTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCATCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAATCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT58375 WP_000861987.1 NZ_CP013316:115088-115345 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT58375 NZ_CP013316:115088-115345 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C3LV30

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References