Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 115088..115635 Replicon chromosome
Accession NZ_CP013316
Organism Vibrio cholerae strain M2140

Toxin (Protein)


Gene name relE Uniprot ID C3LV30
Locus tag ASZ83_RS14560 Protein ID WP_000229318.1
Coordinates 115333..115635 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag ASZ83_RS14555 Protein ID WP_000861987.1
Coordinates 115088..115345 (+) Length 86 a.a.

Genomic Context

ASZ83_RS14500ASZ83_RS14505ASZ83_RS14515ASZ83_RS14520ASZ83_RS19990ASZ83_RS19995ASZ83_RS14540ASZ83_RS14555ASZ83_RS14560ASZ83_RS14565ASZ83_RS14570ASZ83_RS20010ASZ83_RS14585ASZ83_RS14595ASZ83_RS14600ASZ83_RS14605ASZ83_RS20435ASZ83_RS14525ASZ83_RS14530ASZ83_RS14545ASZ83_RS14550
Location: 110231..110344 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 110293..110574 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 110832..111368 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 111505..112020 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 113329..113454 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 113470..113508 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 113704..114150 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 115088..115345 (258 bp)
Type: Antitoxin
Protein ID: WP_000861987.1
Location: 115333..115635 (303 bp)
Type: Toxin
Protein ID: WP_000229318.1
Location: 115924..116148 (225 bp)
Type: Others
Protein ID: WP_001894423.1
Location: 116592..116711 (120 bp)
Type: Others
Protein ID: WP_071919600.1
Location: 116715..116768 (54 bp)
Type: Others
Protein ID: Protein_123
Location: 117370..118374 (1005 bp)
Type: Others
Protein ID: WP_000964931.1
Location: 119149..119329 (181 bp)
Type: Others
Protein ID: Protein_125
Location: 119596..119883 (288 bp)
Type: Others
Protein ID: WP_001162670.1
Location: 119894..120211 (318 bp)
Type: Others
Protein ID: WP_001232701.1
Location: 120208..120318 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 112170..112667 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 112664..112936 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 114298..114567 (270 bp)
Type: Others
Protein ID: WP_000277238.1
Location: 114560..114838 (279 bp)
Type: Others
Protein ID: WP_001258569.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ83_RS14500110231..110344+114WP_001900214.1hypothetical protein-
ASZ83_RS14505110293..110574+282WP_001894429.1DUF1289 domain-containing protein-
ASZ83_RS14515110832..111368+537WP_000469482.1GNAT family N-acetyltransferase-
ASZ83_RS14520111505..112020+516WP_001201509.1lipocalin family protein-
ASZ83_RS14525112170..112667-498WP_000982260.1GNAT family N-acetyltransferase-
ASZ83_RS14530112664..112936-273WP_000246253.1DUF1778 domain-containing protein-
ASZ83_RS19990113329..113454+126WP_001900195.1DUF645 family protein-
ASZ83_RS19995113470..113508+39WP_106019118.1hypothetical protein-
ASZ83_RS14540113704..114150+447WP_000006157.1hypothetical protein-
ASZ83_RS14545114298..114567-270WP_000277238.1type II toxin-antitoxin system YafQ family toxin-
ASZ83_RS14550114560..114838-279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
ASZ83_RS14555115088..115345+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
ASZ83_RS14560115333..115635+303WP_000229318.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ASZ83_RS14565115924..116148+225WP_001894423.1DUF3709 domain-containing protein-
ASZ83_RS14570116592..116711+120WP_071919600.1DUF645 family protein-
ASZ83_RS20010116715..116768+54Protein_123DUF645 family protein-
ASZ83_RS14585117370..118374+1005WP_000964931.1LD-carboxypeptidase-
ASZ83_RS14595119149..119329+181Protein_125DUF645 family protein-
ASZ83_RS14600119596..119883+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ83_RS14605119894..120211+318WP_001232701.1HigA family addiction module antidote protein-
ASZ83_RS20435120208..120318+111WP_134814058.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--87981..224211136230
insideIntegron--93061..221594128533


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11751.69 Da        Isoelectric Point: 5.1972

>T58375 WP_000229318.1 NZ_CP013316:115333-115635 [Vibrio cholerae]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRIPPELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T58375 NZ_CP013316:115333-115635 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCCGGCTCTATCCGACCTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCATCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAATCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT58375 WP_000861987.1 NZ_CP013316:115088-115345 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT58375 NZ_CP013316:115088-115345 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBC3LV30

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1T4SLM9

References