Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 322682..323260 Replicon chromosome
Accession NZ_LT907990
Organism Vibrio cholerae strain A19

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag ALC86_RS15355 Protein ID WP_001180243.1
Coordinates 322682..322999 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag ALC86_RS15360 Protein ID WP_000557292.1
Coordinates 323018..323260 (-) Length 81 a.a.

Genomic Context

ALC86_RS15325ALC86_RS15330ALC86_RS15335ALC86_RS15340ALC86_RS15345ALC86_RS15350ALC86_RS15365ALC86_RS15370ALC86_RS15375ALC86_RS15385ALC86_RS15390ALC86_RS15415ALC86_RS19535ALC86_RS15425ALC86_RS15355ALC86_RS15360ALC86_RS15400ALC86_RS15405
Location: 318206..318388 (183 bp)
Type: Others
Protein ID: WP_000923340.1
Location: 318742..318924 (183 bp)
Type: Others
Protein ID: WP_000923153.1
Location: 319119..319796 (678 bp)
Type: Others
Protein ID: WP_000254617.1
Location: 319958..321166 (1209 bp)
Type: Others
Protein ID: WP_000272282.1
Location: 321328..322032 (705 bp)
Type: Others
Protein ID: WP_000087610.1
Location: 322190..322528 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 323504..323890 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 323947..324060 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 324009..324290 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 324548..325084 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 325221..325736 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 327045..327170 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 327186..327224 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 327420..327866 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 322682..322999 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 323018..323260 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
Location: 325886..326383 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 326380..326652 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ALC86_RS15325318206..318388+183WP_000923340.1DUF645 family protein-
ALC86_RS15330318742..318924+183WP_000923153.1DUF645 family protein-
ALC86_RS15335319119..319796+678WP_000254617.1HNH endonuclease-
ALC86_RS15340319958..321166+1209WP_000272282.1deoxyguanosinetriphosphate triphosphohydrolase family protein-
ALC86_RS15345321328..322032+705WP_000087610.1HNH endonuclease-
ALC86_RS15350322190..322528+339WP_000713853.1hypothetical protein-
ALC86_RS15355322682..322999-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ALC86_RS15360323018..323260-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
ALC86_RS15365323504..323890+387WP_001015867.1NUDIX hydrolase-
ALC86_RS15370323947..324060+114WP_001900214.1hypothetical protein-
ALC86_RS15375324009..324290+282WP_001894429.1DUF1289 domain-containing protein-
ALC86_RS15385324548..325084+537WP_000469482.1GNAT family N-acetyltransferase-
ALC86_RS15390325221..325736+516WP_001201509.1lipocalin family protein-
ALC86_RS15400325886..326383-498WP_000982260.1GNAT family N-acetyltransferase-
ALC86_RS15405326380..326652-273WP_000246253.1DUF1778 domain-containing protein-
ALC86_RS15415327045..327170+126WP_001900195.1DUF645 family protein-
ALC86_RS19535327186..327224+39WP_106019118.1hypothetical protein-
ALC86_RS15425327420..327866+447WP_000006157.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304666..435761131095
insideIntegroncatB9-309746..435385125639


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T293821 WP_001180243.1 NZ_LT907990:c322999-322682 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT293821 WP_000557292.1 NZ_LT907990:c323260-323018 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References