145831

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafN(antitoxin)
Location 388062..388699 Replicon chromosome
Accession NZ_CP047298
Organism Vibrio cholerae O1 biovar El Tor strain C6709

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GTF73_RS15775 Protein ID WP_000869997.1
Coordinates 388340..388699 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D0IIK3
Locus tag GTF73_RS15770 Protein ID WP_000086649.1
Coordinates 388062..388343 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF73_RS15735 383184..383543 + 360 WP_001071514.1 VOC family protein -
GTF73_RS15740 383726..384049 + 324 WP_001889156.1 DUF3709 domain-containing protein -
GTF73_RS15745 384330..384866 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
GTF73_RS15750 385627..385809 + 183 WP_000947517.1 DUF645 family protein -
GTF73_RS15755 385928..386713 + 786 WP_001176447.1 hypothetical protein -
GTF73_RS15760 386815..387177 + 363 WP_170831679.1 DUF4144 domain-containing protein -
GTF73_RS15765 387423..387848 + 426 WP_000735184.1 hypothetical protein -
GTF73_RS15770 388062..388343 + 282 WP_000086649.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GTF73_RS15775 388340..388699 + 360 WP_000869997.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTF73_RS15780 388804..389127 + 324 WP_001999495.1 DUF3709 domain-containing protein -
GTF73_RS15785 389413..389808 + 396 WP_000870868.1 DUF3465 domain-containing protein -
GTF73_RS15790 389875..389989 + 115 Protein_401 acetyltransferase -
GTF73_RS15795 389998..390219 + 222 WP_043987927.1 DUF1289 domain-containing protein -
GTF73_RS15800 390195..390353 - 159 WP_001909351.1 DUF1196 family protein -
GTF73_RS15805 390583..391008 + 426 WP_000415748.1 hypothetical protein -
GTF73_RS15810 391334..391567 + 234 WP_001999499.1 DUF3709 domain-containing protein -
GTF73_RS15815 391756..392151 + 396 WP_001889207.1 DUF4144 domain-containing protein -
GTF73_RS15820 392370..392759 + 390 WP_000491261.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306901..436162 129261
inside Integron - - 311981..435786 123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-74)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13608.84 Da        Isoelectric Point: 8.1459

>T145831 WP_000869997.1 NZ_CP047298:388340-388699 [Vibrio cholerae O1 biovar El Tor]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTLRQEQTVNPPHNKRLKRDCQRVAFPVPLSRGGCSCCV

Download         Length: 360 bp

>T145831 NZ_CP062702:278537-278644 [Escherichia coli O157:H7]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10361.93 Da        Isoelectric Point: 5.1548

>AT145831 WP_000086649.1 NZ_CP047298:388062-388343 [Vibrio cholerae O1 biovar El Tor]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK

Download         Length: 282 bp

>AT145831 NZ_CP062702:c278489-278423 [Escherichia coli O157:H7]
GGTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0K9UIW4

References