Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 327985..328525 Replicon chromosome II
Accession NC_016945
Organism Vibrio cholerae IEC224

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag O3Y_RS15480 Protein ID WP_000277238.1
Coordinates 327985..328254 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag O3Y_RS15485 Protein ID WP_001258569.1
Coordinates 328247..328525 (-) Length 93 a.a.

Genomic Context

O3Y_RS15435O3Y_RS19615O3Y_RS15440O3Y_RS15450O3Y_RS15455O3Y_RS20140O3Y_RS20145O3Y_RS15475O3Y_RS19625O3Y_RS20160O3Y_RS20165O3Y_RS15490O3Y_RS15495O3Y_RS19635O3Y_RS15500O3Y_RS15505O3Y_RS20580O3Y_RS20585O3Y_RS15515O3Y_RS15430O3Y_RS15460O3Y_RS15465O3Y_RS15480O3Y_RS15485
Location: 323475..323861 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 323918..324031 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 323980..324261 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 324519..325055 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 325192..325707 (516 bp)
Type: Others
Protein ID: WP_001201510.1
Location: 327016..327141 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 327157..327195 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 327391..327837 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 328811..329089 (279 bp)
Type: Others
Protein ID: WP_001921601.1
Location: 329341..329547 (207 bp)
Type: Others
Protein ID: Protein_292
Location: 329747..329848 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 329838..330224 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 330419..330670 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 330643..330792 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 330884..331126 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 331378..331656 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 332031..332174 (144 bp)
Type: Others
Protein ID: Protein_299
Location: 332228..332266 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 332478..332945 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 322989..323231 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 325857..326354 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 326351..326623 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 327985..328254 (270 bp)
Type: Toxin
Protein ID: WP_000277238.1
Location: 328247..328525 (279 bp)
Type: Antitoxin
Protein ID: WP_001258569.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
O3Y_RS15430322989..323231-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
O3Y_RS15435323475..323861+387WP_001015867.1NUDIX hydrolase-
O3Y_RS19615323918..324031+114WP_001900214.1hypothetical protein-
O3Y_RS15440323980..324261+282WP_001894429.1DUF1289 domain-containing protein-
O3Y_RS15450324519..325055+537WP_000469482.1GNAT family N-acetyltransferase-
O3Y_RS15455325192..325707+516WP_001201510.1lipocalin family protein-
O3Y_RS15460325857..326354-498WP_000982260.1GNAT family N-acetyltransferase-
O3Y_RS15465326351..326623-273WP_000246253.1DUF1778 domain-containing protein-
O3Y_RS20140327016..327141+126WP_001900195.1DUF645 family protein-
O3Y_RS20145327157..327195+39WP_106019118.1hypothetical protein-
O3Y_RS15475327391..327837+447WP_000006157.1hypothetical protein-
O3Y_RS15480327985..328254-270WP_000277238.1type II toxin-antitoxin system YafQ family toxinToxin
O3Y_RS15485328247..328525-279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
O3Y_RS19625328811..329089+279WP_001921601.1DUF3709 domain-containing protein-
O3Y_RS20160329341..329547+207Protein_292DUF3709 domain-containing protein-
O3Y_RS20165329747..329848+102WP_001921603.1hypothetical protein-
O3Y_RS15490329838..330224+387WP_000703163.1VOC family protein-
O3Y_RS15495330419..330670+252WP_001890111.1TIGR03643 family protein-
O3Y_RS19635330643..330792+150WP_071908333.1DUF3265 domain-containing protein-
O3Y_RS15500330884..331126+243WP_000107461.1hypothetical protein-
O3Y_RS15505331378..331656+279WP_000280324.1DUF3709 domain-containing protein-
O3Y_RS20580332031..332174+144Protein_299DUF645 family protein-
O3Y_RS20585332228..332266+39WP_082798268.1hypothetical protein-
O3Y_RS15515332478..332945+468WP_001289288.1OsmC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304637..435582130945
insideIntegron--309717..435206125489


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T26145 WP_000277238.1 NC_016945:c328254-327985 [Vibrio cholerae IEC224]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T26145 NC_016945:c328254-327985 [Vibrio cholerae IEC224]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT26145 WP_001258569.1 NC_016945:c328525-328247 [Vibrio cholerae IEC224]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT26145 NC_016945:c328525-328247 [Vibrio cholerae IEC224]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A151JGK8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A151KTP9

References