26145

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 327985..328525 Replicon chromosome II
Accession NC_016945
Organism Vibrio cholerae IEC224

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag O3Y_RS15480 Protein ID WP_000277238.1
Coordinates 327985..328254 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag O3Y_RS15485 Protein ID WP_001258569.1
Coordinates 328247..328525 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3Y_RS15430 322989..323231 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
O3Y_RS15435 323475..323861 + 387 WP_001015867.1 NUDIX hydrolase -
O3Y_RS19615 323918..324031 + 114 WP_001900214.1 hypothetical protein -
O3Y_RS15440 323980..324261 + 282 WP_001894429.1 DUF1289 domain-containing protein -
O3Y_RS15450 324519..325055 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
O3Y_RS15455 325192..325707 + 516 WP_001201510.1 lipocalin family protein -
O3Y_RS15460 325857..326354 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
O3Y_RS15465 326351..326623 - 273 WP_000246253.1 DUF1778 domain-containing protein -
O3Y_RS20140 327016..327141 + 126 WP_001900195.1 DUF645 family protein -
O3Y_RS20145 327157..327195 + 39 WP_106019118.1 hypothetical protein -
O3Y_RS15475 327391..327837 + 447 WP_000006157.1 hypothetical protein -
O3Y_RS15480 327985..328254 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
O3Y_RS15485 328247..328525 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
O3Y_RS19625 328811..329089 + 279 WP_001921601.1 DUF3709 domain-containing protein -
O3Y_RS20160 329341..329547 + 207 Protein_292 DUF3709 domain-containing protein -
O3Y_RS20165 329747..329848 + 102 WP_001921603.1 hypothetical protein -
O3Y_RS15490 329838..330224 + 387 WP_000703163.1 VOC family protein -
O3Y_RS15495 330419..330670 + 252 WP_001890111.1 TIGR03643 family protein -
O3Y_RS19635 330643..330792 + 150 WP_071908333.1 DUF3265 domain-containing protein -
O3Y_RS15500 330884..331126 + 243 WP_000107461.1 hypothetical protein -
O3Y_RS15505 331378..331656 + 279 WP_000280324.1 DUF3709 domain-containing protein -
O3Y_RS20580 332031..332174 + 144 Protein_299 DUF645 family protein -
O3Y_RS20585 332228..332266 + 39 WP_082798268.1 hypothetical protein -
O3Y_RS15515 332478..332945 + 468 WP_001289288.1 OsmC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304637..435582 130945
inside Integron - - 309717..435206 125489


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T26145 WP_000277238.1 NC_016945:c328254-327985 [Vibrio cholerae IEC224]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T26145 NC_016945:c328254-327985 [Vibrio cholerae IEC224]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT26145 WP_001258569.1 NC_016945:c328525-328247 [Vibrio cholerae IEC224]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT26145 NC_016945:c328525-328247 [Vibrio cholerae IEC224]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References