Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 586523..587070 Replicon chromosome
Accession NZ_CP013310
Organism Vibrio cholerae strain E1162

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag ASZ87_RS17740 Protein ID WP_000229317.1
Coordinates 586768..587070 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag ASZ87_RS17735 Protein ID WP_000861987.1
Coordinates 586523..586780 (+) Length 86 a.a.

Genomic Context

ASZ87_RS17685ASZ87_RS17695ASZ87_RS17710ASZ87_RS17715ASZ87_RS17720ASZ87_RS17725ASZ87_RS17730ASZ87_RS17735ASZ87_RS17740ASZ87_RS17745ASZ87_RS17755ASZ87_RS17760ASZ87_RS17765ASZ87_RS17770ASZ87_RS17780ASZ87_RS17785ASZ87_RS20835ASZ87_RS17700ASZ87_RS17705
Location: 581552..582007 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 582329..582481 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 583680..584348 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 584500..584787 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 584928..585299 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 585366..585791 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 585788..586321 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 586523..586780 (258 bp)
Type: Antitoxin
Protein ID: WP_000861987.1
Location: 586768..587070 (303 bp)
Type: Toxin
Protein ID: WP_000229317.1
Location: 587304..588221 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 588378..588767 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 588903..589112 (210 bp)
Type: Others
Protein ID: Protein_630
Location: 589231..589668 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 589732..589950 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 590125..590997 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 591147..591746 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 591803..591907 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 582683..583180 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 583177..583449 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ87_RS17685581552..582007+456WP_001245327.1GNAT family N-acetyltransferase-
ASZ87_RS17695582329..582481+153WP_001884520.1DUF645 family protein-
ASZ87_RS17700582683..583180-498WP_000982260.1GNAT family N-acetyltransferase-
ASZ87_RS17705583177..583449-273WP_000246253.1DUF1778 domain-containing protein-
ASZ87_RS17710583680..584348+669WP_000043871.1hypothetical protein-
ASZ87_RS17715584500..584787+288WP_000426470.1hypothetical protein-
ASZ87_RS17720584928..585299+372WP_001164080.1nucleotide pyrophosphohydrolase-
ASZ87_RS17725585366..585791+426WP_001882332.1DUF1778 domain-containing protein-
ASZ87_RS17730585788..586321+534WP_000118351.1GNAT family N-acetyltransferase-
ASZ87_RS17735586523..586780+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
ASZ87_RS17740586768..587070+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ASZ87_RS17745587304..588221+918WP_000186333.1alpha/beta hydrolase-
ASZ87_RS17755588378..588767+390WP_001081302.1hypothetical protein-
ASZ87_RS17760588903..589112+210Protein_630GNAT family N-acetyltransferase-
ASZ87_RS17765589231..589668+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
ASZ87_RS17770589732..589950+219WP_071908318.1GNAT family N-acetyltransferase-
ASZ87_RS17780590125..590997+873WP_000254716.1DUF3800 domain-containing protein-
ASZ87_RS17785591147..591746+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
ASZ87_RS20835591803..591907+105WP_099607150.1acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-435534..596659161125
insideIntegron--440614..596283155669
flankIS/Tn--589231..589668437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T58320 WP_000229317.1 NZ_CP013310:586768-587070 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T58320 NZ_CP013310:586768-587070 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT58320 WP_000861987.1 NZ_CP013310:586523-586780 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT58320 NZ_CP013310:586523-586780 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM92

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1T4SLM9

References