58368

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) dhiT-phd/-
Location 463608..464012 Replicon chromosome
Accession NZ_CP013314
Organism Vibrio cholerae strain E9120

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag ASZ79_RS17030 Protein ID WP_001114075.1
Coordinates 463743..464012 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag ASZ79_RS20765 Protein ID WP_099607150.1
Coordinates 463608..463712 (+) Length 35 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ79_RS16985 459109..460026 + 918 WP_000186333.1 alpha/beta hydrolase -
ASZ79_RS16995 460183..460572 + 390 WP_001081302.1 hypothetical protein -
ASZ79_RS17000 460708..460917 + 210 Protein_519 GNAT family N-acetyltransferase -
ASZ79_RS17005 461036..461473 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
ASZ79_RS17010 461537..461755 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
ASZ79_RS17020 461930..462802 + 873 WP_000254716.1 DUF3800 domain-containing protein -
ASZ79_RS17025 462952..463551 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
ASZ79_RS20765 463608..463712 + 105 WP_099607150.1 acetyltransferase Antitoxin
ASZ79_RS17030 463743..464012 + 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
ASZ79_RS17035 464006..464527 + 522 WP_000921691.1 DUF2442 domain-containing protein -
ASZ79_RS20770 464826..464951 + 126 WP_001905700.1 DUF645 family protein -
ASZ79_RS17050 465202..465597 + 396 WP_001000867.1 hypothetical protein -
ASZ79_RS17055 465736..466014 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
ASZ79_RS17060 466011..466295 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
ASZ79_RS17065 466489..467004 + 516 WP_000343779.1 GNAT family N-acetyltransferase -
ASZ79_RS17070 467188..467601 + 414 WP_000049420.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304700..468464 163764
inside Integron - - 309780..468088 158308
flank IS/Tn - - 461036..461473 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T58368 WP_001114075.1 NZ_CP013314:463743-464012 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T58368 NZ_CP013314:463743-464012 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 35 a.a.        Molecular weight: 3991.79 Da        Isoelectric Point: 9.2853

>AT58368 WP_099607150.1 NZ_CP013314:463608-463712 [Vibrio cholerae]
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL

Download         Length: 105 bp

>AT58368 NZ_CP013314:463608-463712 [Vibrio cholerae]
GTGGTTTCGGTTGTTGTGTTTGAGTTTAGTAGTATGCGCTGCCAGCCCCTTAGGCGGGCGTTATATGCTTATAGGAATTG
TCTCCTAAAGGATACGCTGCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure

References