Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 415937..416570 Replicon chromosome
Accession NZ_CP047304
Organism Vibrio cholerae O1 biovar El Tor strain E7946

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag GTF74_RS16005 Protein ID WP_000843587.1
Coordinates 415937..416269 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GTF74_RS16010 Protein ID WP_000071008.1
Coordinates 416256..416570 (+) Length 105 a.a.

Genomic Context

GTF74_RS15940GTF74_RS15945GTF74_RS15950GTF74_RS15955GTF74_RS15960GTF74_RS15965GTF74_RS15970GTF74_RS15975GTF74_RS15980GTF74_RS15990GTF74_RS15995GTF74_RS16005GTF74_RS16010GTF74_RS16015GTF74_RS16020GTF74_RS16030GTF74_RS16035GTF74_RS16040GTF74_RS16045GTF74_RS16050GTF74_RS16055GTF74_RS16060GTF74_RS15985GTF74_RS16000GTF74_RS16025
Location: 411378..411581 (204 bp)
Type: Others
Protein ID: WP_001911745.1
Location: 411862..412035 (174 bp)
Type: Others
Protein ID: WP_001882305.1
Location: 412395..412664 (270 bp)
Type: Others
Protein ID: WP_001198131.1
Location: 412975..413061 (87 bp)
Type: Others
Protein ID: WP_134820423.1
Location: 413061..413153 (93 bp)
Type: Others
Protein ID: Protein_438
Location: 413362..413748 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 413950..414192 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 414363..414740 (378 bp)
Type: Others
Protein ID: WP_000411109.1
Location: 414920..415141 (222 bp)
Type: Others
Protein ID: WP_032468461.1
Location: 415307..415420 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 415369..415596 (228 bp)
Type: Others
Protein ID: WP_001894457.1
Location: 415937..416269 (333 bp)
Type: Toxin
Protein ID: WP_000843587.1
Location: 416256..416570 (315 bp)
Type: Antitoxin
Protein ID: WP_000071008.1
Location: 416707..417141 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 417309..417464 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 418637..418909 (273 bp)
Type: Others
Protein ID: Protein_452
Location: 419080..419772 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 419772..420173 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 420143..420286 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 420361..420774 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 420988..421239 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 421229..421516 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 415117..415275 (159 bp)
Type: Others
Protein ID: WP_001894455.1
Location: 415626..415784 (159 bp)
Type: Others
Protein ID: WP_001882309.1
Location: 417589..418569 (981 bp)
Type: Others
Protein ID: WP_000019370.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTF74_RS15940411378..411581+204WP_001911745.1hypothetical protein-
GTF74_RS15945411862..412035+174WP_001882305.1DUF3709 domain-containing protein-
GTF74_RS15950412395..412664+270WP_001198131.1hypothetical protein-
GTF74_RS15955412975..413061+87WP_134820423.1DUF645 family protein-
GTF74_RS15960413061..413153+93Protein_438DUF645 family protein-
GTF74_RS15965413362..413748+387WP_000703163.1VOC family protein-
GTF74_RS15970413950..414192+243WP_000107461.1hypothetical protein-
GTF74_RS15975414363..414740+378WP_000411109.1hypothetical protein-
GTF74_RS15980414920..415141+222WP_032468461.1DUF1289 domain-containing protein-
GTF74_RS15985415117..415275-159WP_001894455.1DUF1196 family protein-
GTF74_RS15990415307..415420+114WP_001889158.1hypothetical protein-
GTF74_RS15995415369..415596+228WP_001894457.1DUF1289 domain-containing protein-
GTF74_RS16000415626..415784-159WP_001882309.1DUF1196 family protein-
GTF74_RS16005415937..416269+333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GTF74_RS16010416256..416570+315WP_000071008.1DNA-binding transcriptional regulatorAntitoxin
GTF74_RS16015416707..417141+435WP_000256036.1GNAT family N-acetyltransferase-
GTF74_RS16020417309..417464+156WP_000751734.1hypothetical protein-
GTF74_RS16025417589..418569-981WP_000019370.1IS5-like element ISVch5 family transposase-
GTF74_RS16030418637..418909+273Protein_452CatB-related O-acetyltransferase-
GTF74_RS16035419080..419772+693WP_001047169.1GNAT family N-acetyltransferase-
GTF74_RS16040419772..420173+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
GTF74_RS16045420143..420286+144WP_071908341.1DUF3265 domain-containing protein-
GTF74_RS16050420361..420774+414WP_000049417.1VOC family protein-
GTF74_RS16055420988..421239+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
GTF74_RS16060421229..421516+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-307032..436751129719
insideIntegron--312112..436375124263
flankIS/Tn--417589..418569980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T145893 WP_000843587.1 NZ_CP047304:415937-416269 [Vibrio cholerae O1 biovar El Tor]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

>T145893 NZ_CP062708:284691-284798 [Escherichia coli O157:H7]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT145893 WP_000071008.1 NZ_CP047304:416256-416570 [Vibrio cholerae O1 biovar El Tor]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT145893 NZ_CP062708:c284643-284577 [Escherichia coli O157:H7]
GGTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB5JA9
PDB8A0X
PDB5MJE
PDB5JA8
PDB5JAA

Antitoxin

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Source
ID
Structure
No matching records found

References