145893

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 415937..416570 Replicon chromosome
Accession NZ_CP047304
Organism Vibrio cholerae O1 biovar El Tor strain E7946

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag GTF74_RS16005 Protein ID WP_000843587.1
Coordinates 415937..416269 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GTF74_RS16010 Protein ID WP_000071008.1
Coordinates 416256..416570 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF74_RS15940 411378..411581 + 204 WP_001911745.1 hypothetical protein -
GTF74_RS15945 411862..412035 + 174 WP_001882305.1 DUF3709 domain-containing protein -
GTF74_RS15950 412395..412664 + 270 WP_001198131.1 hypothetical protein -
GTF74_RS15955 412975..413061 + 87 WP_134820423.1 DUF645 family protein -
GTF74_RS15960 413061..413153 + 93 Protein_438 DUF645 family protein -
GTF74_RS15965 413362..413748 + 387 WP_000703163.1 VOC family protein -
GTF74_RS15970 413950..414192 + 243 WP_000107461.1 hypothetical protein -
GTF74_RS15975 414363..414740 + 378 WP_000411109.1 hypothetical protein -
GTF74_RS15980 414920..415141 + 222 WP_032468461.1 DUF1289 domain-containing protein -
GTF74_RS15985 415117..415275 - 159 WP_001894455.1 DUF1196 family protein -
GTF74_RS15990 415307..415420 + 114 WP_001889158.1 hypothetical protein -
GTF74_RS15995 415369..415596 + 228 WP_001894457.1 DUF1289 domain-containing protein -
GTF74_RS16000 415626..415784 - 159 WP_001882309.1 DUF1196 family protein -
GTF74_RS16005 415937..416269 + 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTF74_RS16010 416256..416570 + 315 WP_000071008.1 DNA-binding transcriptional regulator Antitoxin
GTF74_RS16015 416707..417141 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
GTF74_RS16020 417309..417464 + 156 WP_000751734.1 hypothetical protein -
GTF74_RS16025 417589..418569 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
GTF74_RS16030 418637..418909 + 273 Protein_452 CatB-related O-acetyltransferase -
GTF74_RS16035 419080..419772 + 693 WP_001047169.1 GNAT family N-acetyltransferase -
GTF74_RS16040 419772..420173 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
GTF74_RS16045 420143..420286 + 144 WP_071908341.1 DUF3265 domain-containing protein -
GTF74_RS16050 420361..420774 + 414 WP_000049417.1 VOC family protein -
GTF74_RS16055 420988..421239 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GTF74_RS16060 421229..421516 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 307032..436751 129719
inside Integron - - 312112..436375 124263
flank IS/Tn - - 417589..418569 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T145893 WP_000843587.1 NZ_CP047304:415937-416269 [Vibrio cholerae O1 biovar El Tor]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

>T145893 NZ_CP062708:284691-284798 [Escherichia coli O157:H7]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT145893 WP_000071008.1 NZ_CP047304:416256-416570 [Vibrio cholerae O1 biovar El Tor]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT145893 NZ_CP062708:c284643-284577 [Escherichia coli O157:H7]
GGTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5JA9
PDB 8A0X
PDB 5MJE
PDB 5JA8
PDB 5JAA

Antitoxin

Source ID Structure

References