Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) dhiT-phd/-
Location 434436..434840 Replicon chromosome
Accession NZ_CP047300
Organism Vibrio cholerae O1 biovar El Tor strain P27459

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag GTF71_RS15855 Protein ID WP_001114075.1
Coordinates 434571..434840 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag GTF71_RS15850 Protein ID WP_099607150.1
Coordinates 434436..434540 (+) Length 35 a.a.

Genomic Context

GTF71_RS15815GTF71_RS15820GTF71_RS15825GTF71_RS15830GTF71_RS15835GTF71_RS15840GTF71_RS15845GTF71_RS15850GTF71_RS15855GTF71_RS15860GTF71_RS15865GTF71_RS15870GTF71_RS15885GTF71_RS15890GTF71_RS15895GTF71_RS15875GTF71_RS15880GTF71_RS15900
Location: 429937..430854 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 431011..431400 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 431536..431745 (210 bp)
Type: Others
Protein ID: Protein_475
Location: 431864..432301 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 432365..432583 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 432758..433630 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 433780..434379 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 434436..434540 (105 bp)
Type: Antitoxin
Protein ID: WP_099607150.1
Location: 434571..434840 (270 bp)
Type: Toxin
Protein ID: WP_001114075.1
Location: 434834..435355 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 435654..435779 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 436030..436425 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 437317..437832 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 437889..437984 (96 bp)
Type: Others
Protein ID: WP_099607151.1
Location: 438016..438429 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 436564..436842 (279 bp)
Type: Others
Protein ID: WP_000578476.1
Location: 436839..437123 (285 bp)
Type: Others
Protein ID: WP_000381183.1
Location: 438436..438568 (133 bp)
Type: Others
Protein ID: Protein_490
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTF71_RS15815429937..430854+918WP_000186333.1alpha/beta hydrolase-
GTF71_RS15820431011..431400+390WP_001081302.1hypothetical protein-
GTF71_RS15825431536..431745+210Protein_475GNAT family N-acetyltransferase-
GTF71_RS15830431864..432301+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
GTF71_RS15835432365..432583+219WP_071908318.1GNAT family N-acetyltransferase-
GTF71_RS15840432758..433630+873WP_000254716.1DUF3800 domain-containing protein-
GTF71_RS15845433780..434379+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
GTF71_RS15850434436..434540+105WP_099607150.1acetyltransferaseAntitoxin
GTF71_RS15855434571..434840+270WP_001114075.1DUF4160 domain-containing proteinToxin
GTF71_RS15860434834..435355+522WP_000921691.1DUF2442 domain-containing protein-
GTF71_RS15865435654..435779+126WP_001905700.1DUF645 family protein-
GTF71_RS15870436030..436425+396WP_001000867.1hypothetical protein-
GTF71_RS15875436564..436842-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family-
GTF71_RS15880436839..437123-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
GTF71_RS15885437317..437832+516WP_000343779.1GNAT family N-acetyltransferase-
GTF71_RS15890437889..437984+96WP_099607151.1acetyltransferase-
GTF71_RS15895438016..438429+414WP_000049420.1VOC family protein-
GTF71_RS15900438436..438568-133Protein_490hypothetical protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306926..439292132366
insideIntegron--312006..438916126910
flankIS/Tn--431864..432301437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T145859 WP_001114075.1 NZ_CP047300:434571-434840 [Vibrio cholerae O1 biovar El Tor]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T145859 NZ_CP062703:52842-53147 [Escherichia coli O157:H7]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 35 a.a.        Molecular weight: 3991.79 Da        Isoelectric Point: 9.2853

>AT145859 WP_099607150.1 NZ_CP047300:434436-434540 [Vibrio cholerae O1 biovar El Tor]
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL

Download         Length: 105 bp

>AT145859 NZ_CP062703:52622-52840 [Escherichia coli O157:H7]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A086SLD6

Antitoxin

Loading, please wait
Source
ID
Structure
No matching records found

References