Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 91657..92235 Replicon chromosome
Accession NZ_CP007635
Organism Vibrio cholerae strain 2012EL-2176

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag EN18_RS14725 Protein ID WP_001180243.1
Coordinates 91657..91974 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag EN18_RS14730 Protein ID WP_000557292.1
Coordinates 91993..92235 (-) Length 81 a.a.

Genomic Context

EN18_RS14690EN18_RS20615EN18_RS14695EN18_RS14700EN18_RS14710EN18_RS14715EN18_RS14720EN18_RS21380EN18_RS21555EN18_RS14735EN18_RS14740EN18_RS14745EN18_RS20640EN18_RS14750EN18_RS14755EN18_RS14760EN18_RS21560EN18_RS21565EN18_RS21570EN18_RS14725EN18_RS14730
Location: 86848..87243 (396 bp)
Type: Others
Protein ID: WP_000046952.1
Location: 87546..87727 (182 bp)
Type: Others
Protein ID: Protein_126
Location: 87904..88299 (396 bp)
Type: Others
Protein ID: WP_000046953.1
Location: 88443..88979 (537 bp)
Type: Others
Protein ID: WP_000644491.1
Location: 89276..89455 (180 bp)
Type: Others
Protein ID: WP_001883039.1
Location: 89651..90076 (426 bp)
Type: Others
Protein ID: WP_000403014.1
Location: 90225..90572 (348 bp)
Type: Others
Protein ID: WP_000933409.1
Location: 90719..91012 (294 bp)
Type: Others
Protein ID: WP_125460920.1
Location: 91368..91463 (96 bp)
Type: Others
Protein ID: WP_001907607.1
Location: 92477..92986 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 93043..93696 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 94006..94224 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 94627..94860 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 95285..95465 (181 bp)
Type: Others
Protein ID: Protein_140
Location: 95732..96019 (288 bp)
Type: Others
Protein ID: WP_001162670.1
Location: 96030..96347 (318 bp)
Type: Others
Protein ID: WP_001232701.1
Location: 96344..96454 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 96631..96756 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 96772..96810 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 91657..91974 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 91993..92235 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EN18_RS1469086848..87243+396WP_000046952.1hypothetical protein-
EN18_RS2061587546..87727+182Protein_126DUF645 family protein-
EN18_RS1469587904..88299+396WP_000046953.1hypothetical protein-
EN18_RS1470088443..88979+537WP_000644491.1nucleotidyltransferase family protein-
EN18_RS1471089276..89455+180WP_001883039.1DUF645 family protein-
EN18_RS1471589651..90076+426WP_000403014.1GNAT family N-acetyltransferase-
EN18_RS1472090225..90572+348WP_000933409.1hypothetical protein-
EN18_RS2138090719..91012+294WP_125460920.1hypothetical protein-
EN18_RS2155591368..91463+96WP_001907607.1DUF645 family protein-
EN18_RS1472591657..91974-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
EN18_RS1473091993..92235-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
EN18_RS1473592477..92986+510WP_000405987.1GNAT family N-acetyltransferase-
EN18_RS1474093043..93696+654WP_000226874.1hypothetical protein-
EN18_RS1474594006..94224+219WP_001917086.1DUF3709 domain-containing protein-
EN18_RS2064094627..94860+234WP_032482776.1DUF3709 domain-containing protein-
EN18_RS1475095285..95465+181Protein_140DUF645 family protein-
EN18_RS1475595732..96019+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxin-
EN18_RS1476096030..96347+318WP_001232701.1HigA family addiction module antidote protein-
EN18_RS2156096344..96454+111WP_134814058.1DUF3265 domain-containing protein-
EN18_RS2156596631..96756+126WP_001944767.1DUF645 family protein-
EN18_RS2157096772..96810+39WP_106019119.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-31037..137542106505
insideIntegron--36117..137166101049


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T46755 WP_001180243.1 NZ_CP007635:c91974-91657 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T46755 NZ_CP007635:c91974-91657 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT46755 WP_000557292.1 NZ_CP007635:c92235-91993 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT46755 NZ_CP007635:c92235-91993 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References