46755

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 91657..92235 Replicon chromosome
Accession NZ_CP007635
Organism Vibrio cholerae strain 2012EL-2176

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag EN18_RS14725 Protein ID WP_001180243.1
Coordinates 91657..91974 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag EN18_RS14730 Protein ID WP_000557292.1
Coordinates 91993..92235 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EN18_RS14690 86848..87243 + 396 WP_000046952.1 hypothetical protein -
EN18_RS20615 87546..87727 + 182 Protein_126 DUF645 family protein -
EN18_RS14695 87904..88299 + 396 WP_000046953.1 hypothetical protein -
EN18_RS14700 88443..88979 + 537 WP_000644491.1 nucleotidyltransferase family protein -
EN18_RS14710 89276..89455 + 180 WP_001883039.1 DUF645 family protein -
EN18_RS14715 89651..90076 + 426 WP_000403014.1 GNAT family N-acetyltransferase -
EN18_RS14720 90225..90572 + 348 WP_000933409.1 hypothetical protein -
EN18_RS21380 90719..91012 + 294 WP_125460920.1 hypothetical protein -
EN18_RS21555 91368..91463 + 96 WP_001907607.1 DUF645 family protein -
EN18_RS14725 91657..91974 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EN18_RS14730 91993..92235 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EN18_RS14735 92477..92986 + 510 WP_000405987.1 GNAT family N-acetyltransferase -
EN18_RS14740 93043..93696 + 654 WP_000226874.1 hypothetical protein -
EN18_RS14745 94006..94224 + 219 WP_001917086.1 DUF3709 domain-containing protein -
EN18_RS20640 94627..94860 + 234 WP_032482776.1 DUF3709 domain-containing protein -
EN18_RS14750 95285..95465 + 181 Protein_140 DUF645 family protein -
EN18_RS14755 95732..96019 + 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
EN18_RS14760 96030..96347 + 318 WP_001232701.1 HigA family addiction module antidote protein -
EN18_RS21560 96344..96454 + 111 WP_134814058.1 DUF3265 domain-containing protein -
EN18_RS21565 96631..96756 + 126 WP_001944767.1 DUF645 family protein -
EN18_RS21570 96772..96810 + 39 WP_106019119.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 31037..137542 106505
inside Integron - - 36117..137166 101049


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T46755 WP_001180243.1 NZ_CP007635:c91974-91657 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T46755 NZ_CP007635:c91974-91657 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT46755 WP_000557292.1 NZ_CP007635:c92235-91993 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT46755 NZ_CP007635:c92235-91993 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References