26151

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 399115..399643 Replicon chromosome II
Accession NC_016945
Organism Vibrio cholerae IEC224

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag O3Y_RS16015 Protein ID WP_000221352.1
Coordinates 399115..399405 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag O3Y_RS16020 Protein ID WP_000213183.1
Coordinates 399395..399643 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3Y_RS20620 394672..394797 + 126 WP_001944767.1 DUF645 family protein -
O3Y_RS20625 394813..394851 + 39 WP_106019119.1 hypothetical protein -
O3Y_RS15990 395064..396068 + 1005 WP_000964925.1 LD-carboxypeptidase -
O3Y_RS15995 396221..396667 + 447 WP_000128977.1 hypothetical protein -
O3Y_RS16000 396787..397716 + 930 WP_000335802.1 hypothetical protein -
O3Y_RS20300 397713..397823 + 111 WP_071917832.1 DUF3265 domain-containing protein -
O3Y_RS16005 397851..398327 + 477 WP_001047179.1 GNAT family N-acetyltransferase -
O3Y_RS16010 398464..398979 + 516 WP_001201528.1 lipocalin family protein -
O3Y_RS16015 399115..399405 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
O3Y_RS16020 399395..399643 - 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
O3Y_RS16035 400214..400867 + 654 WP_000036955.1 site-specific DNA-methyltransferase -
O3Y_RS16040 401139..401564 + 426 WP_000415748.1 hypothetical protein -
O3Y_RS16045 401772..402167 + 396 WP_000649527.1 DUF3465 domain-containing protein -
O3Y_RS16050 402318..402848 + 531 WP_000415563.1 hypothetical protein -
O3Y_RS16055 402986..403486 + 501 WP_000789723.1 hypothetical protein -
O3Y_RS16060 403642..404040 + 399 WP_001882293.1 hypothetical protein -
O3Y_RS16065 404140..404604 - 465 WP_000140244.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304637..435582 130945
inside Integron - - 309717..435206 125489


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T26151 WP_000221352.1 NC_016945:c399405-399115 [Vibrio cholerae IEC224]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T26151 NC_016945:c399405-399115 [Vibrio cholerae IEC224]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT26151 WP_000213183.1 NC_016945:c399643-399395 [Vibrio cholerae IEC224]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT26151 NC_016945:c399643-399395 [Vibrio cholerae IEC224]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References