Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 399115..399643 Replicon chromosome II
Accession NC_016945
Organism Vibrio cholerae IEC224

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag O3Y_RS16015 Protein ID WP_000221352.1
Coordinates 399115..399405 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag O3Y_RS16020 Protein ID WP_000213183.1
Coordinates 399395..399643 (-) Length 83 a.a.

Genomic Context

O3Y_RS20620O3Y_RS20625O3Y_RS15990O3Y_RS15995O3Y_RS16000O3Y_RS20300O3Y_RS16005O3Y_RS16010O3Y_RS16035O3Y_RS16040O3Y_RS16045O3Y_RS16050O3Y_RS16055O3Y_RS16060O3Y_RS16015O3Y_RS16020O3Y_RS16065
Location: 394672..394797 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 394813..394851 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 395064..396068 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 396221..396667 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 396787..397716 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 397713..397823 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 397851..398327 (477 bp)
Type: Others
Protein ID: WP_001047179.1
Location: 398464..398979 (516 bp)
Type: Others
Protein ID: WP_001201528.1
Location: 400214..400867 (654 bp)
Type: Others
Protein ID: WP_000036955.1
Location: 401139..401564 (426 bp)
Type: Others
Protein ID: WP_000415748.1
Location: 401772..402167 (396 bp)
Type: Others
Protein ID: WP_000649527.1
Location: 402318..402848 (531 bp)
Type: Others
Protein ID: WP_000415563.1
Location: 402986..403486 (501 bp)
Type: Others
Protein ID: WP_000789723.1
Location: 403642..404040 (399 bp)
Type: Others
Protein ID: WP_001882293.1
Location: 399115..399405 (291 bp)
Type: Toxin
Protein ID: WP_000221352.1
Location: 399395..399643 (249 bp)
Type: Antitoxin
Protein ID: WP_000213183.1
Location: 404140..404604 (465 bp)
Type: Others
Protein ID: WP_000140244.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
O3Y_RS20620394672..394797+126WP_001944767.1DUF645 family protein-
O3Y_RS20625394813..394851+39WP_106019119.1hypothetical protein-
O3Y_RS15990395064..396068+1005WP_000964925.1LD-carboxypeptidase-
O3Y_RS15995396221..396667+447WP_000128977.1hypothetical protein-
O3Y_RS16000396787..397716+930WP_000335802.1hypothetical protein-
O3Y_RS20300397713..397823+111WP_071917832.1DUF3265 domain-containing protein-
O3Y_RS16005397851..398327+477WP_001047179.1GNAT family N-acetyltransferase-
O3Y_RS16010398464..398979+516WP_001201528.1lipocalin family protein-
O3Y_RS16015399115..399405-291WP_000221352.1type II toxin-antitoxin system RelE/ParE family toxinToxin
O3Y_RS16020399395..399643-249WP_000213183.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
O3Y_RS16035400214..400867+654WP_000036955.1site-specific DNA-methyltransferase-
O3Y_RS16040401139..401564+426WP_000415748.1hypothetical protein-
O3Y_RS16045401772..402167+396WP_000649527.1DUF3465 domain-containing protein-
O3Y_RS16050402318..402848+531WP_000415563.1hypothetical protein-
O3Y_RS16055402986..403486+501WP_000789723.1hypothetical protein-
O3Y_RS16060403642..404040+399WP_001882293.1hypothetical protein-
O3Y_RS16065404140..404604-465WP_000140244.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304637..435582130945
insideIntegron--309717..435206125489


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T26151 WP_000221352.1 NC_016945:c399405-399115 [Vibrio cholerae IEC224]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T26151 NC_016945:c399405-399115 [Vibrio cholerae IEC224]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT26151 WP_000213183.1 NC_016945:c399643-399395 [Vibrio cholerae IEC224]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT26151 NC_016945:c399643-399395 [Vibrio cholerae IEC224]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBH9L4R3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366A3W8

References