Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 942836..943414 Replicon chromosome
Accession NZ_LT992487
Organism Vibrio cholerae strain 4295STDY6534216

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag DG247_RS18790 Protein ID WP_001180243.1
Coordinates 943097..943414 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag DG247_RS18785 Protein ID WP_000557292.1
Coordinates 942836..943078 (+) Length 81 a.a.

Genomic Context

DG247_RS18785DG247_RS18790DG247_RS19820DG247_RS19825DG247_RS19830DG247_RS18750DG247_RS18755DG247_RS18760DG247_RS18765DG247_RS18770DG247_RS18775DG247_RS18780DG247_RS19835DG247_RS19675DG247_RS18810DG247_RS18815DG247_RS18820DG247_RS18825DG247_RS18830DG247_RS18835DG247_RS18840
Location: 942836..943078 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
Location: 943097..943414 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 938261..938299 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 938315..938440 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 938617..938727 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 938724..939041 (318 bp)
Type: Others
Protein ID: WP_001232701.1
Location: 939052..939339 (288 bp)
Type: Others
Protein ID: WP_001162670.1
Location: 939606..939786 (181 bp)
Type: Others
Protein ID: Protein_830
Location: 940211..940444 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 940847..941065 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 941375..942028 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 942085..942594 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 943608..943703 (96 bp)
Type: Others
Protein ID: WP_001907607.1
Location: 944059..944352 (294 bp)
Type: Others
Protein ID: WP_125460920.1
Location: 944499..944846 (348 bp)
Type: Others
Protein ID: WP_000933409.1
Location: 944995..945420 (426 bp)
Type: Others
Protein ID: WP_000403014.1
Location: 945616..945795 (180 bp)
Type: Others
Protein ID: WP_001883039.1
Location: 946092..946628 (537 bp)
Type: Others
Protein ID: WP_000644491.1
Location: 946772..947167 (396 bp)
Type: Others
Protein ID: WP_000046953.1
Location: 947344..947525 (182 bp)
Type: Others
Protein ID: Protein_844
Location: 947828..948223 (396 bp)
Type: Others
Protein ID: WP_000046952.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DG247_RS19820938261..938299-39WP_106019119.1hypothetical protein-
DG247_RS19825938315..938440-126WP_001944767.1DUF645 family protein-
DG247_RS19830938617..938727-111WP_134814058.1DUF3265 domain-containing protein-
DG247_RS18750938724..939041-318WP_001232701.1HigA family addiction module antidote protein-
DG247_RS18755939052..939339-288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxin-
DG247_RS18760939606..939786-181Protein_830DUF645 family protein-
DG247_RS18765940211..940444-234WP_032482776.1DUF3709 domain-containing protein-
DG247_RS18770940847..941065-219WP_001917086.1DUF3709 domain-containing protein-
DG247_RS18775941375..942028-654WP_000226874.1hypothetical protein-
DG247_RS18780942085..942594-510WP_000405987.1GNAT family N-acetyltransferase-
DG247_RS18785942836..943078+243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
DG247_RS18790943097..943414+318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
DG247_RS19835943608..943703-96WP_001907607.1DUF645 family protein-
DG247_RS19675944059..944352-294WP_125460920.1hypothetical protein-
DG247_RS18810944499..944846-348WP_000933409.1hypothetical protein-
DG247_RS18815944995..945420-426WP_000403014.1GNAT family N-acetyltransferase-
DG247_RS18820945616..945795-180WP_001883039.1DUF645 family protein-
DG247_RS18825946092..946628-537WP_000644491.1nucleotidyltransferase family protein-
DG247_RS18830946772..947167-396WP_000046953.1hypothetical protein-
DG247_RS18835947344..947525-182Protein_844DUF645 family protein-
DG247_RS18840947828..948223-396WP_000046952.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-897525..99449796972
insideIntegroncatB9-897901..98770989808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T294359 WP_001180243.1 NZ_LT992487:943097-943414 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT294359 WP_000557292.1 NZ_LT992487:942836-943078 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References