Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 95732..96347 Replicon chromosome
Accession NZ_CP007635
Organism Vibrio cholerae strain 2012EL-2176

Toxin (Protein)


Gene name higB Uniprot ID Q9KMG5
Locus tag EN18_RS14755 Protein ID WP_001162670.1
Coordinates 95732..96019 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EN18_RS14760 Protein ID WP_001232701.1
Coordinates 96030..96347 (+) Length 106 a.a.

Genomic Context

EN18_RS21555EN18_RS14735EN18_RS14740EN18_RS14745EN18_RS20640EN18_RS14750EN18_RS14755EN18_RS14760EN18_RS21560EN18_RS21565EN18_RS21570EN18_RS14770EN18_RS14775EN18_RS14780EN18_RS21185EN18_RS14785EN18_RS14790EN18_RS14725EN18_RS14730
Location: 91368..91463 (96 bp)
Type: Others
Protein ID: WP_001907607.1
Location: 92477..92986 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 93043..93696 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 94006..94224 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 94627..94860 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 95285..95465 (181 bp)
Type: Others
Protein ID: Protein_140
Location: 95732..96019 (288 bp)
Type: Toxin
Protein ID: WP_001162670.1
Location: 96030..96347 (318 bp)
Type: Antitoxin
Protein ID: WP_001232701.1
Location: 96344..96454 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 96631..96756 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 96772..96810 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 97023..98027 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 98180..98626 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 98746..99675 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 99672..99782 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 99810..100286 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 100423..100938 (516 bp)
Type: Others
Protein ID: WP_001201528.1
Location: 91657..91974 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 91993..92235 (243 bp)
Type: Others
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EN18_RS2155591368..91463+96WP_001907607.1DUF645 family protein-
EN18_RS1472591657..91974-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
EN18_RS1473091993..92235-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
EN18_RS1473592477..92986+510WP_000405987.1GNAT family N-acetyltransferase-
EN18_RS1474093043..93696+654WP_000226874.1hypothetical protein-
EN18_RS1474594006..94224+219WP_001917086.1DUF3709 domain-containing protein-
EN18_RS2064094627..94860+234WP_032482776.1DUF3709 domain-containing protein-
EN18_RS1475095285..95465+181Protein_140DUF645 family protein-
EN18_RS1475595732..96019+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxinToxin
EN18_RS1476096030..96347+318WP_001232701.1HigA family addiction module antidote proteinAntitoxin
EN18_RS2156096344..96454+111WP_134814058.1DUF3265 domain-containing protein-
EN18_RS2156596631..96756+126WP_001944767.1DUF645 family protein-
EN18_RS2157096772..96810+39WP_106019119.1hypothetical protein-
EN18_RS1477097023..98027+1005WP_000964925.1LD-carboxypeptidase-
EN18_RS1477598180..98626+447WP_000128977.1hypothetical protein-
EN18_RS1478098746..99675+930WP_000335802.1hypothetical protein-
EN18_RS2118599672..99782+111WP_071917832.1DUF3265 domain-containing protein-
EN18_RS1478599810..100286+477WP_001047180.1GNAT family N-acetyltransferase-
EN18_RS14790100423..100938+516WP_001201528.1lipocalin family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-31037..137542106505
insideIntegron--36117..137166101049


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11349.95 Da        Isoelectric Point: 6.7187

>T46756 WP_001162670.1 NZ_CP007635:95732-96019 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Download         Length: 288 bp

>T46756 NZ_CP007635:95732-96019 [Vibrio cholerae]
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11705.63 Da        Isoelectric Point: 10.4711

>AT46756 WP_001232701.1 NZ_CP007635:96030-96347 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Download         Length: 318 bp

>AT46756 NZ_CP007635:96030-96347 [Vibrio cholerae]
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTCAGTAATTTAATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCCGCGGCATTAGGTAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F2HI36

Antitoxin

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Source
ID
Structure
No matching records found

References