145401

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 390345..390978 Replicon chromosome
Accession NZ_CP047060
Organism Vibrio cholerae isolate CTMA_1441

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag GQX72_RS15845 Protein ID WP_000843587.1
Coordinates 390345..390677 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GQX72_RS15850 Protein ID WP_000071008.1
Coordinates 390664..390978 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQX72_RS19045 385786..385989 + 204 WP_001911745.1 hypothetical protein -
GQX72_RS15790 386270..386443 + 174 WP_001882305.1 DUF3709 domain-containing protein -
GQX72_RS15795 386803..387072 + 270 WP_001198131.1 hypothetical protein -
GQX72_RS15800 387390..387561 + 172 Protein_391 DUF645 family protein -
GQX72_RS15805 387770..388156 + 387 WP_000703163.1 VOC family protein -
GQX72_RS15810 388358..388600 + 243 WP_000107461.1 hypothetical protein -
GQX72_RS15815 388771..389148 + 378 WP_000411106.1 hypothetical protein -
GQX72_RS19050 389205..389319 + 115 Protein_395 acetyltransferase -
GQX72_RS15820 389268..389549 + 282 WP_001894453.1 DUF1289 domain-containing protein -
GQX72_RS15830 389715..389828 + 114 WP_001889158.1 hypothetical protein -
GQX72_RS15835 389777..390004 + 228 WP_001894457.1 DUF1289 domain-containing protein -
GQX72_RS15845 390345..390677 + 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GQX72_RS15850 390664..390978 + 315 WP_000071008.1 DNA-binding transcriptional regulator Antitoxin
GQX72_RS15855 391115..391549 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
GQX72_RS15860 391717..391872 + 156 WP_000751734.1 hypothetical protein -
GQX72_RS15865 391997..392977 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
GQX72_RS15870 393045..393351 + 307 Protein_404 CatB-related O-acetyltransferase -
GQX72_RS15875 393488..394180 + 693 WP_001047169.1 GNAT family N-acetyltransferase -
GQX72_RS15880 394180..394581 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
GQX72_RS15885 394551..394694 + 144 WP_071908341.1 DUF3265 domain-containing protein -
GQX72_RS15890 394769..395182 + 414 WP_000049417.1 VOC family protein -
GQX72_RS15895 395396..395647 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GQX72_RS15900 395637..395924 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 305960..411159 105199
inside Integron - - 311040..410783 99743
flank IS/Tn - - 391997..392977 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T145401 WP_000843587.1 NZ_CP047060:390345-390677 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

>T145401 NZ_CP062376:1167415-1167603 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT145401 WP_000071008.1 NZ_CP047060:390664-390978 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT145401 NZ_CP062376:1167126-1167386 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5JA9
PDB 8A0X
PDB 5MJE
PDB 5JA8
PDB 5JAA

Antitoxin

Source ID Structure

References