Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 323568..324146 Replicon chromosome
Accession NZ_CP072850
Organism Vibrio cholerae MO10

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag KAF59_RS15235 Protein ID WP_001180243.1
Coordinates 323568..323885 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag KAF59_RS15240 Protein ID WP_000557292.1
Coordinates 323904..324146 (-) Length 81 a.a.

Genomic Context

KAF59_RS15205KAF59_RS18795KAF59_RS15210KAF59_RS15215KAF59_RS15220KAF59_RS15225KAF59_RS15230KAF59_RS15245KAF59_RS15250KAF59_RS15255KAF59_RS15260KAF59_RS15265KAF59_RS18800KAF59_RS15280KAF59_RS15290KAF59_RS15235KAF59_RS15240KAF59_RS15270KAF59_RS15275
Location: 319092..319274 (183 bp)
Type: Others
Protein ID: WP_000923340.1
Location: 319394..319456 (63 bp)
Type: Others
Protein ID: Protein_273
Location: 319628..319810 (183 bp)
Type: Others
Protein ID: WP_000923153.1
Location: 320005..320682 (678 bp)
Type: Others
Protein ID: WP_000254617.1
Location: 320844..322052 (1209 bp)
Type: Others
Protein ID: WP_000272282.1
Location: 322214..322918 (705 bp)
Type: Others
Protein ID: WP_000087610.1
Location: 323076..323414 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 324390..324776 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 324833..324946 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 324955..325176 (222 bp)
Type: Others
Protein ID: WP_032467793.1
Location: 325434..325970 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 326161..326622 (462 bp)
Type: Others
Protein ID: WP_001903091.1
Location: 326687..326755 (69 bp)
Type: Others
Protein ID: Protein_286
Location: 327931..328056 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 328306..328752 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 323568..323885 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 323904..324146 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
Location: 326772..327269 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 327266..327538 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KAF59_RS15205 (KAF59_15205)319092..319274+183WP_000923340.1DUF645 family protein-
KAF59_RS18795319394..319456+63Protein_273acetyltransferase-
KAF59_RS15210 (KAF59_15210)319628..319810+183WP_000923153.1DUF645 family protein-
KAF59_RS15215 (KAF59_15215)320005..320682+678WP_000254617.1HNH endonuclease signature motif containing protein-
KAF59_RS15220 (KAF59_15220)320844..322052+1209WP_000272282.1deoxyguanosinetriphosphate triphosphohydrolase family protein-
KAF59_RS15225 (KAF59_15225)322214..322918+705WP_000087610.1HNH endonuclease-
KAF59_RS15230 (KAF59_15230)323076..323414+339WP_000713853.1hypothetical protein-
KAF59_RS15235 (KAF59_15235)323568..323885-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
KAF59_RS15240 (KAF59_15240)323904..324146-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
KAF59_RS15245 (KAF59_15245)324390..324776+387WP_001015867.1NUDIX hydrolase-
KAF59_RS15250 (KAF59_15250)324833..324946+114WP_001900214.1hypothetical protein-
KAF59_RS15255 (KAF59_15255)324955..325176+222WP_032467793.1DUF1289 domain-containing protein-
KAF59_RS15260 (KAF59_15260)325434..325970+537WP_000469482.1GNAT family protein-
KAF59_RS15265 (KAF59_15265)326161..326622+462WP_001903091.1lipocalin family protein-
KAF59_RS18800326687..326755+69Protein_286acetyltransferase-
KAF59_RS15270 (KAF59_15270)326772..327269-498WP_000982260.1GNAT family N-acetyltransferase-
KAF59_RS15275 (KAF59_15275)327266..327538-273WP_000246253.1DUF1778 domain-containing protein-
KAF59_RS15280 (KAF59_15280)327931..328056+126WP_001900195.1DUF645 family protein-
KAF59_RS15290 (KAF59_15290)328306..328752+447WP_000006157.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306928..40218995261
insideIntegroncatB9-312008..40181389805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T198998 WP_001180243.1 NZ_CP072850:c323885-323568 [Vibrio cholerae MO10]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T198998 NZ_CP097082:c4820622-4819705 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCAATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT198998 WP_000557292.1 NZ_CP072850:c324146-323904 [Vibrio cholerae MO10]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT198998 NZ_CP097082:c4821386-4820628 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References