198998

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 323568..324146 Replicon chromosome
Accession NZ_CP072850
Organism Vibrio cholerae MO10

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag KAF59_RS15235 Protein ID WP_001180243.1
Coordinates 323568..323885 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag KAF59_RS15240 Protein ID WP_000557292.1
Coordinates 323904..324146 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAF59_RS15205 (KAF59_15205) 319092..319274 + 183 WP_000923340.1 DUF645 family protein -
KAF59_RS18795 319394..319456 + 63 Protein_273 acetyltransferase -
KAF59_RS15210 (KAF59_15210) 319628..319810 + 183 WP_000923153.1 DUF645 family protein -
KAF59_RS15215 (KAF59_15215) 320005..320682 + 678 WP_000254617.1 HNH endonuclease signature motif containing protein -
KAF59_RS15220 (KAF59_15220) 320844..322052 + 1209 WP_000272282.1 deoxyguanosinetriphosphate triphosphohydrolase family protein -
KAF59_RS15225 (KAF59_15225) 322214..322918 + 705 WP_000087610.1 HNH endonuclease -
KAF59_RS15230 (KAF59_15230) 323076..323414 + 339 WP_000713853.1 hypothetical protein -
KAF59_RS15235 (KAF59_15235) 323568..323885 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KAF59_RS15240 (KAF59_15240) 323904..324146 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KAF59_RS15245 (KAF59_15245) 324390..324776 + 387 WP_001015867.1 NUDIX hydrolase -
KAF59_RS15250 (KAF59_15250) 324833..324946 + 114 WP_001900214.1 hypothetical protein -
KAF59_RS15255 (KAF59_15255) 324955..325176 + 222 WP_032467793.1 DUF1289 domain-containing protein -
KAF59_RS15260 (KAF59_15260) 325434..325970 + 537 WP_000469482.1 GNAT family protein -
KAF59_RS15265 (KAF59_15265) 326161..326622 + 462 WP_001903091.1 lipocalin family protein -
KAF59_RS18800 326687..326755 + 69 Protein_286 acetyltransferase -
KAF59_RS15270 (KAF59_15270) 326772..327269 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
KAF59_RS15275 (KAF59_15275) 327266..327538 - 273 WP_000246253.1 DUF1778 domain-containing protein -
KAF59_RS15280 (KAF59_15280) 327931..328056 + 126 WP_001900195.1 DUF645 family protein -
KAF59_RS15290 (KAF59_15290) 328306..328752 + 447 WP_000006157.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306928..402189 95261
inside Integron catB9 - 312008..401813 89805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T198998 WP_001180243.1 NZ_CP072850:c323885-323568 [Vibrio cholerae MO10]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T198998 NZ_CP097082:c4820622-4819705 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCAATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT198998 WP_000557292.1 NZ_CP072850:c324146-323904 [Vibrio cholerae MO10]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT198998 NZ_CP097082:c4821386-4820628 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References