95390

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) dhiT-phd/-
Location 131378..131782 Replicon chromosome
Accession NZ_CP026648
Organism Vibrio cholerae O1 biovar El Tor strain HC1037

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag C4E16_RS15290 Protein ID WP_001114075.1
Coordinates 131513..131782 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag C4E16_RS15285 Protein ID WP_099607150.1
Coordinates 131378..131482 (+) Length 35 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4E16_RS15250 126879..127796 + 918 WP_000186333.1 alpha/beta hydrolase -
C4E16_RS15255 127953..128342 + 390 WP_001081302.1 hypothetical protein -
C4E16_RS15260 128478..128687 + 210 Protein_202 GNAT family N-acetyltransferase -
C4E16_RS15265 128806..129243 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
C4E16_RS15270 129307..129525 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
C4E16_RS15275 129700..130572 + 873 WP_000254716.1 DUF3800 domain-containing protein -
C4E16_RS15280 130722..131321 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
C4E16_RS15285 131378..131482 + 105 WP_099607150.1 acetyltransferase Antitoxin
C4E16_RS15290 131513..131782 + 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
C4E16_RS15295 131776..132297 + 522 WP_000921691.1 DUF2442 domain-containing protein -
C4E16_RS15300 132596..132721 + 126 WP_001905700.1 DUF645 family protein -
C4E16_RS15310 132972..133367 + 396 WP_001000867.1 hypothetical protein -
C4E16_RS15315 133506..133784 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
C4E16_RS15320 133781..134065 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
C4E16_RS15325 134259..134774 + 516 WP_000343779.1 GNAT family N-acetyltransferase -
C4E16_RS15335 134958..135371 + 414 WP_000049420.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 31043..136234 105191
inside Integron - - 36123..135858 99735
flank IS/Tn - - 128806..129243 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T95390 WP_001114075.1 NZ_CP026648:131513-131782 [Vibrio cholerae O1 biovar El Tor]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T95390 NZ_CP026648:131513-131782 [Vibrio cholerae O1 biovar El Tor]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 35 a.a.        Molecular weight: 3991.79 Da        Isoelectric Point: 9.2853

>AT95390 WP_099607150.1 NZ_CP026648:131378-131482 [Vibrio cholerae O1 biovar El Tor]
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL

Download         Length: 105 bp

>AT95390 NZ_CP026648:131378-131482 [Vibrio cholerae O1 biovar El Tor]
GTGGTTTCGGTTGTTGTGTTTGAGTTTAGTAGTATGCGCTGCCAGCCCCTTAGGCGGGCGTTATATGCTTATAGGAATTG
TCTCCTAAAGGATACGCTGCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure

References