Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 280180..280739 Replicon chromosome
Accession NZ_AP024554
Organism Vibrio cholerae strain IDH-03329

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag K6J80_RS15365 Protein ID WP_000578476.1
Coordinates 280461..280739 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag K6J80_RS15360 Protein ID WP_000381183.1
Coordinates 280180..280464 (+) Length 95 a.a.

Genomic Context

K6J80_RS15360K6J80_RS15365K6J80_RS15320K6J80_RS15325K6J80_RS15330K6J80_RS15335K6J80_RS15340K6J80_RS15345K6J80_RS19050K6J80_RS15350K6J80_RS15355K6J80_RS15370K6J80_RS19055K6J80_RS15375K6J80_RS15380K6J80_RS15385K6J80_RS19060K6J80_RS15390K6J80_RS15395K6J80_RS15400K6J80_RS15405
Location: 280180..280464 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
Location: 280461..280739 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 275846..275935 (90 bp)
Type: Others
Protein ID: WP_072606010.1
Location: 275966..276664 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 276787..277413 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 277455..277547 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 277562..278035 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 278235..278417 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 278478..278615 (138 bp)
Type: Others
Protein ID: WP_001890145.1
Location: 278809..279405 (597 bp)
Type: Others
Protein ID: WP_000255434.1
Location: 279470..279931 (462 bp)
Type: Others
Protein ID: WP_001911578.1
Location: 280890..281303 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 281378..281494 (117 bp)
Type: Others
Protein ID: WP_086010882.1
Location: 281491..281970 (480 bp)
Type: Others
Protein ID: WP_000009888.1
Location: 282183..282806 (624 bp)
Type: Others
Protein ID: WP_000247070.1
Location: 283012..283437 (426 bp)
Type: Others
Protein ID: WP_000415750.1
Location: 283584..283733 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 283706..283957 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 284152..284355 (204 bp)
Type: Others
Protein ID: WP_001911580.1
Location: 284612..284998 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 285155..285661 (507 bp)
Type: Others
Protein ID: WP_000393074.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K6J80_RS15320275846..275935-90WP_072606010.1DUF3265 domain-containing protein-
K6J80_RS15325275966..276664-699WP_001890502.1hypothetical protein-
K6J80_RS15330276787..277413-627WP_000365424.1LysE family translocator-
K6J80_RS15335277455..277547-93WP_014378730.1DUF3265 domain-containing protein-
K6J80_RS15340277562..278035-474WP_001161076.1GrpB family protein-
K6J80_RS15345278235..278417-183WP_000923182.1DUF645 family protein-
K6J80_RS19050278478..278615-138WP_001890145.1hypothetical protein-
K6J80_RS15350278809..279405-597WP_000255434.1hypothetical protein-
K6J80_RS15355279470..279931-462WP_001911578.1lipocalin family protein-
K6J80_RS15360280180..280464+285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
K6J80_RS15365280461..280739+279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
K6J80_RS15370280890..281303-414WP_000049420.1VOC family protein-
K6J80_RS19055281378..281494-117WP_086010882.1DUF3265 domain-containing protein-
K6J80_RS15375281491..281970-480WP_000009888.1lecithin retinol acyltransferase family protein-
K6J80_RS15380282183..282806-624WP_000247070.1DUF1349 domain-containing protein-
K6J80_RS15385283012..283437-426WP_000415750.1hypothetical protein-
K6J80_RS19060283584..283733-150WP_071908333.1DUF3265 domain-containing protein-
K6J80_RS15390283706..283957-252WP_001890111.1TIGR03643 family protein-
K6J80_RS15395284152..284355-204WP_001911580.1hypothetical protein-
K6J80_RS15400284612..284998-387WP_000703163.1VOC family protein-
K6J80_RS15405285155..285661-507WP_000393074.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-213119..319686106567
insideIntegron--213119..31285699737


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T38680 WP_000578476.1 NZ_AP024554:280461-280739 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T38680 NZ_AP024554:280461-280739 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT38680 WP_000381183.1 NZ_AP024554:280180-280464 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT38680 NZ_AP024554:280180-280464 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References