38680

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 280180..280739 Replicon chromosome
Accession NZ_AP024554
Organism Vibrio cholerae strain IDH-03329

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag K6J80_RS15365 Protein ID WP_000578476.1
Coordinates 280461..280739 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag K6J80_RS15360 Protein ID WP_000381183.1
Coordinates 280180..280464 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J80_RS15320 275846..275935 - 90 WP_072606010.1 DUF3265 domain-containing protein -
K6J80_RS15325 275966..276664 - 699 WP_001890502.1 hypothetical protein -
K6J80_RS15330 276787..277413 - 627 WP_000365424.1 LysE family translocator -
K6J80_RS15335 277455..277547 - 93 WP_014378730.1 DUF3265 domain-containing protein -
K6J80_RS15340 277562..278035 - 474 WP_001161076.1 GrpB family protein -
K6J80_RS15345 278235..278417 - 183 WP_000923182.1 DUF645 family protein -
K6J80_RS19050 278478..278615 - 138 WP_001890145.1 hypothetical protein -
K6J80_RS15350 278809..279405 - 597 WP_000255434.1 hypothetical protein -
K6J80_RS15355 279470..279931 - 462 WP_001911578.1 lipocalin family protein -
K6J80_RS15360 280180..280464 + 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K6J80_RS15365 280461..280739 + 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
K6J80_RS15370 280890..281303 - 414 WP_000049420.1 VOC family protein -
K6J80_RS19055 281378..281494 - 117 WP_086010882.1 DUF3265 domain-containing protein -
K6J80_RS15375 281491..281970 - 480 WP_000009888.1 lecithin retinol acyltransferase family protein -
K6J80_RS15380 282183..282806 - 624 WP_000247070.1 DUF1349 domain-containing protein -
K6J80_RS15385 283012..283437 - 426 WP_000415750.1 hypothetical protein -
K6J80_RS19060 283584..283733 - 150 WP_071908333.1 DUF3265 domain-containing protein -
K6J80_RS15390 283706..283957 - 252 WP_001890111.1 TIGR03643 family protein -
K6J80_RS15395 284152..284355 - 204 WP_001911580.1 hypothetical protein -
K6J80_RS15400 284612..284998 - 387 WP_000703163.1 VOC family protein -
K6J80_RS15405 285155..285661 - 507 WP_000393074.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 213119..319686 106567
inside Integron - - 213119..312856 99737


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T38680 WP_000578476.1 NZ_AP024554:280461-280739 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T38680 NZ_AP024554:280461-280739 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT38680 WP_000381183.1 NZ_AP024554:280180-280464 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT38680 NZ_AP024554:280180-280464 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References