Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 455310..456076 Replicon chromosome
Accession NZ_CP013302
Organism Vibrio cholerae strain C5

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag ASZ80_RS17015 Protein ID WP_000982260.1
Coordinates 455310..455807 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag ASZ80_RS17020 Protein ID WP_000246253.1
Coordinates 455804..456076 (-) Length 91 a.a.

Genomic Context

ASZ80_RS16965ASZ80_RS16970ASZ80_RS16975ASZ80_RS20690ASZ80_RS16985ASZ80_RS16990ASZ80_RS16995ASZ80_RS17000ASZ80_RS17010ASZ80_RS17025ASZ80_RS17030ASZ80_RS17035ASZ80_RS17040ASZ80_RS17045ASZ80_RS17050ASZ80_RS17055ASZ80_RS17060ASZ80_RS17015ASZ80_RS17020
Location: 451172..451478 (307 bp)
Type: Others
Protein ID: Protein_502
Location: 451615..452307 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 452307..452708 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 452678..452821 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 452896..453309 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 453523..453774 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 453764..454051 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 454179..454634 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 454956..455108 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 456307..456975 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 457127..457414 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 457555..457926 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 457993..458418 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 458415..458948 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 459150..459407 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 459395..459697 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 459931..460848 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 455310..455807 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 455804..456076 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ80_RS16965451172..451478+307Protein_502CatB-related O-acetyltransferase-
ASZ80_RS16970451615..452307+693WP_001047169.1GNAT family N-acetyltransferase-
ASZ80_RS16975452307..452708+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
ASZ80_RS20690452678..452821+144WP_071908341.1DUF3265 domain-containing protein-
ASZ80_RS16985452896..453309+414WP_000049417.1VOC family protein-
ASZ80_RS16990453523..453774+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ80_RS16995453764..454051+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ80_RS17000454179..454634+456WP_001245327.1GNAT family N-acetyltransferase-
ASZ80_RS17010454956..455108+153WP_001884520.1DUF645 family protein-
ASZ80_RS17015455310..455807-498WP_000982260.1GNAT family N-acetyltransferaseToxin
ASZ80_RS17020455804..456076-273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
ASZ80_RS17025456307..456975+669WP_000043871.1hypothetical protein-
ASZ80_RS17030457127..457414+288WP_000426470.1hypothetical protein-
ASZ80_RS17035457555..457926+372WP_001164080.1nucleotide pyrophosphohydrolase-
ASZ80_RS17040457993..458418+426WP_001882332.1DUF1778 domain-containing protein-
ASZ80_RS17045458415..458948+534WP_000118351.1GNAT family N-acetyltransferase-
ASZ80_RS17050459150..459407+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ80_RS17055459395..459697+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ80_RS17060459931..460848+918WP_000186333.1alpha/beta hydrolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304694..469286164592
insideIntegron--309774..468910159136
flankIS/Tn--450124..451104980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T58230 WP_000982260.1 NZ_CP013302:c455807-455310 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T58230 NZ_CP013302:c455807-455310 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT58230 WP_000246253.1 NZ_CP013302:c456076-455804 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT58230 NZ_CP013302:c456076-455804 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References