Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 326198..326738 Replicon chromosome
Accession NZ_CP024163
Organism Vibrio cholerae strain E7946

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag CSW01_RS15670 Protein ID WP_000277238.1
Coordinates 326198..326467 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag CSW01_RS15675 Protein ID WP_001258569.1
Coordinates 326460..326738 (-) Length 93 a.a.

Genomic Context

CSW01_RS15595CSW01_RS15600CSW01_RS15605CSW01_RS15620CSW01_RS15625CSW01_RS15650CSW01_RS19800CSW01_RS15660CSW01_RS15685CSW01_RS19805CSW01_RS15690CSW01_RS15695CSW01_RS15700CSW01_RS15705CSW01_RS15710CSW01_RS15715CSW01_RS19945CSW01_RS19950CSW01_RS15740CSW01_RS15590CSW01_RS15635CSW01_RS15640CSW01_RS15670CSW01_RS15675
Location: 321688..322074 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 322131..322244 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 322193..322474 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 322732..323268 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 323405..323920 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 325229..325354 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 325370..325408 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 325604..326050 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 327024..327302 (279 bp)
Type: Others
Protein ID: WP_001921601.1
Location: 327554..327760 (207 bp)
Type: Others
Protein ID: Protein_289
Location: 327960..328061 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 328051..328437 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 328632..328883 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 328856..329005 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 329097..329339 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 329591..329869 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 330244..330387 (144 bp)
Type: Others
Protein ID: Protein_296
Location: 330441..330479 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 330691..331158 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 321202..321444 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 324070..324567 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 324564..324836 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 326198..326467 (270 bp)
Type: Toxin
Protein ID: WP_000277238.1
Location: 326460..326738 (279 bp)
Type: Antitoxin
Protein ID: WP_001258569.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CSW01_RS15590321202..321444-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
CSW01_RS15595321688..322074+387WP_001015867.1NUDIX hydrolase-
CSW01_RS15600322131..322244+114WP_001900214.1hypothetical protein-
CSW01_RS15605322193..322474+282WP_001894429.1DUF1289 domain-containing protein-
CSW01_RS15620322732..323268+537WP_000469482.1GNAT family N-acetyltransferase-
CSW01_RS15625323405..323920+516WP_001201509.1lipocalin family protein-
CSW01_RS15635324070..324567-498WP_000982260.1GNAT family N-acetyltransferase-
CSW01_RS15640324564..324836-273WP_000246253.1DUF1778 domain-containing protein-
CSW01_RS15650325229..325354+126WP_001900195.1DUF645 family protein-
CSW01_RS19800325370..325408+39WP_106019118.1hypothetical protein-
CSW01_RS15660325604..326050+447WP_000006157.1hypothetical protein-
CSW01_RS15670326198..326467-270WP_000277238.1type II toxin-antitoxin system YafQ family toxinToxin
CSW01_RS15675326460..326738-279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
CSW01_RS15685327024..327302+279WP_001921601.1DUF3709 domain-containing protein-
CSW01_RS19805327554..327760+207Protein_289DUF3709 domain-containing protein-
CSW01_RS15690327960..328061+102WP_001921603.1hypothetical protein-
CSW01_RS15695328051..328437+387WP_000703163.1VOC family protein-
CSW01_RS15700328632..328883+252WP_001890111.1TIGR03643 family protein-
CSW01_RS15705328856..329005+150WP_071908333.1DUF3265 domain-containing protein-
CSW01_RS15710329097..329339+243WP_000107461.1hypothetical protein-
CSW01_RS15715329591..329869+279WP_000280324.1DUF3709 domain-containing protein-
CSW01_RS19945330244..330387+144Protein_296DUF645 family protein-
CSW01_RS19950330441..330479+39WP_082798268.1hypothetical protein-
CSW01_RS15740330691..331158+468WP_001289288.1OsmC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304226..433944129718
insideIntegron--309306..433568124262


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T87018 WP_000277238.1 NZ_CP024163:c326467-326198 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T87018 NZ_CP024163:c326467-326198 [Vibrio cholerae]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT87018 WP_001258569.1 NZ_CP024163:c326738-326460 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT87018 NZ_CP024163:c326738-326460 [Vibrio cholerae]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A151JGK8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A151KTP9

References