87018

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 326198..326738 Replicon chromosome
Accession NZ_CP024163
Organism Vibrio cholerae strain E7946

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag CSW01_RS15670 Protein ID WP_000277238.1
Coordinates 326198..326467 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag CSW01_RS15675 Protein ID WP_001258569.1
Coordinates 326460..326738 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSW01_RS15590 321202..321444 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
CSW01_RS15595 321688..322074 + 387 WP_001015867.1 NUDIX hydrolase -
CSW01_RS15600 322131..322244 + 114 WP_001900214.1 hypothetical protein -
CSW01_RS15605 322193..322474 + 282 WP_001894429.1 DUF1289 domain-containing protein -
CSW01_RS15620 322732..323268 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
CSW01_RS15625 323405..323920 + 516 WP_001201509.1 lipocalin family protein -
CSW01_RS15635 324070..324567 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
CSW01_RS15640 324564..324836 - 273 WP_000246253.1 DUF1778 domain-containing protein -
CSW01_RS15650 325229..325354 + 126 WP_001900195.1 DUF645 family protein -
CSW01_RS19800 325370..325408 + 39 WP_106019118.1 hypothetical protein -
CSW01_RS15660 325604..326050 + 447 WP_000006157.1 hypothetical protein -
CSW01_RS15670 326198..326467 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
CSW01_RS15675 326460..326738 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CSW01_RS15685 327024..327302 + 279 WP_001921601.1 DUF3709 domain-containing protein -
CSW01_RS19805 327554..327760 + 207 Protein_289 DUF3709 domain-containing protein -
CSW01_RS15690 327960..328061 + 102 WP_001921603.1 hypothetical protein -
CSW01_RS15695 328051..328437 + 387 WP_000703163.1 VOC family protein -
CSW01_RS15700 328632..328883 + 252 WP_001890111.1 TIGR03643 family protein -
CSW01_RS15705 328856..329005 + 150 WP_071908333.1 DUF3265 domain-containing protein -
CSW01_RS15710 329097..329339 + 243 WP_000107461.1 hypothetical protein -
CSW01_RS15715 329591..329869 + 279 WP_000280324.1 DUF3709 domain-containing protein -
CSW01_RS19945 330244..330387 + 144 Protein_296 DUF645 family protein -
CSW01_RS19950 330441..330479 + 39 WP_082798268.1 hypothetical protein -
CSW01_RS15740 330691..331158 + 468 WP_001289288.1 OsmC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304226..433944 129718
inside Integron - - 309306..433568 124262


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T87018 WP_000277238.1 NZ_CP024163:c326467-326198 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T87018 NZ_CP024163:c326467-326198 [Vibrio cholerae]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT87018 WP_001258569.1 NZ_CP024163:c326738-326460 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT87018 NZ_CP024163:c326738-326460 [Vibrio cholerae]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References