104346

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 420412..420940 Replicon chromosome
Accession NZ_CP028895
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag A1552VC_RS16790 Protein ID WP_000221354.1
Coordinates 420653..420940 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag A1552VC_RS16785 Protein ID WP_001250179.1
Coordinates 420412..420663 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A1552VC_RS16745 415680..415994 + 315 WP_000071008.1 DNA-binding transcriptional regulator -
A1552VC_RS16750 416131..416565 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
A1552VC_RS19895 416733..416888 + 156 WP_000751734.1 hypothetical protein -
A1552VC_RS16755 417013..417993 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
A1552VC_RS16760 418061..418367 + 307 Protein_445 CatB-related O-acetyltransferase -
A1552VC_RS16765 418504..419196 + 693 WP_001047169.1 GNAT family N-acetyltransferase -
A1552VC_RS16770 419196..419597 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
A1552VC_RS16775 419567..419710 + 144 WP_071908341.1 DUF3265 domain-containing protein -
A1552VC_RS16780 419785..420198 + 414 WP_000049417.1 VOC family protein -
A1552VC_RS16785 420412..420663 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
A1552VC_RS16790 420653..420940 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A1552VC_RS16795 421068..421523 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
A1552VC_RS16800 421845..421997 + 153 WP_001884520.1 DUF645 family protein -
A1552VC_RS16810 422199..422696 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
A1552VC_RS16815 422693..422965 - 273 WP_000246253.1 DUF1778 domain-containing protein -
A1552VC_RS16820 423196..423864 + 669 WP_000043871.1 hypothetical protein -
A1552VC_RS16825 424016..424303 + 288 WP_000426470.1 hypothetical protein -
A1552VC_RS16830 424444..424815 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
A1552VC_RS16835 424882..425307 + 426 WP_001882332.1 DUF1778 domain-containing protein -
A1552VC_RS16840 425304..425837 + 534 WP_000118351.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306914..436175 129261
inside Integron - - 311994..435799 123805
flank IS/Tn - - 417013..417993 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T104346 WP_000221354.1 NZ_CP028895:420653-420940 [Vibrio cholerae]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T104346 NZ_CP028895:420653-420940 [Vibrio cholerae]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT104346 WP_001250179.1 NZ_CP028895:420412-420663 [Vibrio cholerae]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT104346 NZ_CP028895:420412-420663 [Vibrio cholerae]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X1KZS6

Antitoxin

Source ID Structure
AlphaFold DB A0A0X1KZS8

References